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A tall order: Giraffe receives stem-cell therapy for chronic arthritis – Source

Posted: Published on July 12th, 2017

How do veterinarians help a giraffe ease its arthritis pain? Well, it takes a little more than an aspirin and a gulp of water. Recently, Colorado State University veterinarians traveled to Cheyenne Mountain Zoo to help Mahali, a 14-year-old giraffe, with arthritis pain in his front left hoof. Arthritis is a common problem for giraffes, especially geriatric giraffes like Mahali. Who can blame them? Weighing in at 2,000 pounds on average, their four feet support more than one ton of weight. Thats like carrying two grand pianos on your back all day. With its 17-giraffe herd trained for voluntary husbandry, including hoof trims, blood draws and radiographs, Cheyenne Mountain Zoo is uniquely suited to help find better arthritis treatments for giraffes. Dr. Amanda Morphet, who is training to specialize in exotic and zoo animal medicine at CSU, believes stem-cell therapy can help alleviate arthritis pain. Currently, arthritis in these megavertebrates is managed through corrective hoof trims, non-steroidal anti-inflammatories, cold-laser therapy and pain medications. But, these practices are not always enough to keep giraffes, which can live up to 30 years, comfortable as they age. CSU veterinarians Dr. Val Johnson and Dr. Amanda Morphet, and the zoos lead veterinarian Dr. Liza … Continue reading

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Oxford BioMedica wins big contract for Novartis cell therapy – Reuters

Posted: Published on July 12th, 2017

LONDON (Reuters) - Novartis has signed a major contract with Oxford BioMedica that could earn the British company more than $100 million over three years for supplying the Swiss drugmaker with material for its novel cell therapy CTL019. The deal, announced by Oxford BioMedica on Thursday, could help put the veteran biotech firm on a path to sustainable profitability. The contract is for the supply of lentiviral vectors used to generate CTL019, a new kind of treatment for hard-to-treat leukemia that is expected to reach the market this year. A U.S. advisory panel will discuss the case for approving CTL019 at a meeting on July 12 and Novartis has already designated the treatment as a potential blockbuster. Oxford BioMedica will received $10 million from Novartis upfront, as well as payments for various performance incentives and bioprocessing and development services. It will also get a royalty on future sales of CTL-019. Jefferies analysts said this could earn Oxford BioMedica between 65 million and 75 million pounds ($84-97 million) a year, assuming CTL019 peak sales of at least $1 billion. The agreement also covers the supply of vectors for other undisclosed Chimeric Antigen Receptor T cell (CART) products. Reporting by Ben Hirschler; … Continue reading

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Crowdfunding campaign supports biology field study – Cornell Chronicle

Posted: Published on July 12th, 2017

Cornell University Ecology and Evolutionary Biology Crowdfunding Campaign Gopher tortoises and blue jays. A vintage Army-issue shovel. Sun and rain and wind. Hundreds of students who have gone on field studies through the Department of Ecology and Evolutionary Biology over the last 50 years have memories as diverse as the ecosystems they studied. Alumni say their graduate field study was the most important thing they did in graduate school, the spark that ignited their academic career. Its a long-standing tradition in this department, that we expose grad students early in their career to asking questions in nature, said Kelly Zamudio, the Goldwin Smith Professor of Ecology and Evolutionary Biology, a field study instructor. But the course has become more and more expensive over time, which is why the idea of the endowment came about. Wed hate for this class to cease to exist, especially given its history. Field study costs $2,000 per student beyond course tuition. To ensure that future students will have the same life-changing opportunity to pursue two-week field studies at the Archbold Biological Field Station in Florida, EEB hopes to raise $15,000 this month through crowdfunding to cover housing, transportation, field equipment, field trips and lab fees … Continue reading

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Biology test no longer required for high school diploma | The Seattle … – The Seattle Times

Posted: Published on July 12th, 2017

High school seniors will no longer need to pass a biology test in order to graduate under legislation signed by Gov. Jay Inslee. OLYMPIA (AP) High school seniors will no longer need to pass a biology test in order to graduate under legislation signed by Gov. Jay Inslee. The Daily News reports that that seniors in the class of 2017 who had failed a biology exam but met other diploma requirements would graduate automatically. The class of 2017 had been the first class required to pass a biology exam. About 3,300 high school seniors failed it. The new legislation signed by Inslee Friday is intended to give students more flexibility in meeting graduation requirements. The Legislature unanimously approved House Bill 2224 on June 30. The new law delays until 2021 the requirement that students pass a statewide biology test in order to graduate. The legislation moves the states standardized English and math assessments from the 11th grade to the 10th grade. It allows school districts to come up with alternative ways for students to demonstrate proficiency. Continued here: Biology test no longer required for high school diploma | The Seattle ... - The Seattle Times … Continue reading

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Synthetic Biology Advance May Put Microbiomes on the Clock – Genetic Engineering & Biotechnology News

Posted: Published on July 12th, 2017

If a bacterial population is to meet fluctuating production targets, it needs to comply with workforce schedulingnot just by clocking off, but by clocking on, too. To enforce off/on control across entire bacterial populations, scientists based at the University of California, San Diego (UCSD) have developed a framework for the engineering of a DNA master clock at the colony level. This master clock works by combining synthetic biology circuits that can dynamically increase and decrease DNA copy number and thereby turn gene expression up and down. Until now, methods for controlling or programming bacterial cells involved transcriptional and post-transcriptional regulation. The UCSD team, led by Jeff Hasty, Ph.D., worked out a new method. It involves engineering dynamic DNA copy number changes in a synchronized fashion. Details of the new method appeared July 10 in the journal Nature Genetics, in an article entitled Synchronized DNA Cycling across a Bacterial Population. The article describes how DNA concentration can be increased to turn on a synthetic gene circuit. By controlling DNA copy number, researchers can effectively regulate gene expression. We engineered colony-wide DNA cycling inEscherichia coliin the form of plasmid copy number oscillations via a modular design that can be readily adapted for … Continue reading

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Carbon nanotubes mimic biology – Phys.org – Phys.Org

Posted: Published on July 12th, 2017

July 7, 2017 An artists rendition of a carbon nanotube porin embedded in a cell membrane with a single strand of DNA passing through it. Credit: Adam Gardner Proteins in lipid membranes are one of the fundamental building blocks of biological functionality. Lawrence Livermore researchers have figured out how to mimic their role using carbon nanotube porins. Using high-speed, atomic force microscopy (HS-AFM), the team showed that a new type of biomimetic channelcarbon nanotube porins (CNTPs)also is laterally mobile in supported lipid membranes, mirroring biological protein behavior. The research opens the door to use CNTPs as models to study membrane protein physics, as well as versatile and mobile components for artificial cells and hybrid systems that combine biological cells and man-made components. Lipid membranes represent one the fundamental components of the architecture of life because they provide a versatile matrix for a variety of membrane proteins that can perform a variety of tasks including molecular recognition and signal transduction, metabolite transport and membrane remodeling. The 2-D fluid nature of the lipid membrane not only allows it to adapt to a variety of shapes, but also permits membrane proteins to diffuse within this 2-D plane, enabling many important biological processes. "To … Continue reading

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University of Vermont faculty win grant to explore biology major – vtdigger.org

Posted: Published on July 12th, 2017

News Release University of Vermont July 10, 2017 Contact: Jeff Wakefield [emailprotected] 802-578-8830 UVM Faculty Win $300,000 NSF Grant to Explore Making of a Bio Major What can universities learn from the maker movement about teaching biology to undergraduate students? Can the world of making help universities get more creative students excited about careers in biology? The National Science Foundation has awarded a $300,000 grant to a team of faculty at The University of Vermont to find out. The grant went to Andrew Mead, a research associate in the Biology Department, along with former Biology chair Jim Vigoreaux, now an associate provost, and associate professor of English and problem-based learning researcher, Libby Miles. The grant application and the research program it proposes were built around a pilot Biology course created by Mead and Vigoreaux and funded by an Engaged Practices Innovation grant from the Office of the Provost, called BioFabLab. Students in the course design, prototype, and build their own experimental instruments working in partnership with experts at Burlington Generator, a Burlington makerspace to assist Biology faculty in their research. Working in teams, students are given a real research question and, over the course of the semester, develop an experimental … Continue reading

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Sea Spiders Move Oxygen with Pumping Guts, Marine Biologists Say – Sci-News.com

Posted: Published on July 12th, 2017

Marine arthropods called sea spiders use gut peristalsis to move hemolymph and oxygen throughout most of their bodies, according to a team of researchers led by Dr. H. Arthur Woods from the University of Montana. A sea spider on the sea floor. Image credit: Timothy R. Dwyer / PolarTREC 2016 / ARCUS. Sea spiders, or pycnogonids, are small, primarily bottom-dwelling marine arthropods that superficially resemble the true, terrestrial spiders. There are over 1,300 known species, ranging in size from 1 mm to over 90 cm. They are found in the Mediterranean and Caribbean Seas as well as in the Arctic and Antarctic Oceans. Relative to other arthropods, sea spiders have long legs in contrast to a small body size. The number of walking legs is usually 8, but species with 10 and 12 legs exist. Unlike true spiders, sea spiders do not possess a specialized respiratory system oxygen is absorbed by the legs and is transported via hemolymph (fluid, analogous to the blood in vertebrates) to the rest of the body. The sea spiders have an unusual gut in the first place, Dr. Woods said. Unlike us, with our centrally located guts that are all confined to a single body … Continue reading

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SJW’s Melt After Feminist YouTuber Tells Them Human Biology 101 – The Federalist

Posted: Published on July 12th, 2017

Social justice warriors flipped out at feminist YouTuber Laci Green on Saturday after she said the terms male and female refer to biological sexes. Last week, Teen Vogue published a visually explicit and kinda gross article about a certain sex act,which included diagrams of the female and male reproductive anatomy. The diagrams described female anatomy as the anatomy of a non-prostate owner, and described male anatomy as that which belongs to a prostate owner so as to avoid using the terms male and female. But Green pointed out that these descriptions are insane, as the word female literally describes someone who was born with a female reproductive system. These correct statements about human biology were apparently too triggering for social justice warriors to handle, because they raked her over the coals. Someone tried to tell Green shes wrong, saying that a post-operative trans woman that is, a man who undergoes surgery to appear female runs the risk of developing prostate cancer. But this weird statement only proves Greens point that those who are biologically male cant magically become female, even if they like to call themselves that or have their bodies rearranged with plastic surgery. Another asked Green where she … Continue reading

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US Rep. Yarmuth: ‘Keep being loud’ to protect healthcare – Louisville Eccentric Observer

Posted: Published on July 12th, 2017

U.S. Rep John Yarmuth told a crowd recently that the tone of debate over healthcare must change from one of personal attack to one of policy debate. We need to change the tone of our dialogue, it really isnt productive, so if I believe that its accurate to say that a certain health care policy will result in people dying, its OK for me to say that. Its not OK for me to say that the supporters of that proposal are killers. I think thats the kind of distinction we have to make, he said during the town hall meeting Sunday July 10, at Bellarmine University. Im not going to make any personal attacks on people who are supporting policies that I dont support, but I am going to attack the policies that I dont support, he told the audience of more than 700 people. A strong supporter of the Affordable Care Act, Yarmuth discussed how much the bill has benefited Kentucky, in particular causing the uninsured rate to drop to 6.1 percent from 13.6 percent.Every state that expanded Medicaid had huge drops in the number of uninsured as well. Yarmuth said the Senates healthcare proposal, written by Kentuckys senior … Continue reading

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