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Oxford BioMedica signs major deal with Novartis for cell therapy treatment – City A.M.

Posted: Published on July 9th, 2017

An Oxford-based gene and cell therapy group has announced a major deal with Swiss pharmaceuticals company Novartis. Oxford BioMedica today revealed it signed a deal potentially worth more than $100m (77.1m) with Novartis for the supply of material for its new cell therapy, CTL019. The agreement builds on an existing relationship between the two companies that collaborated on CTL019, which will launch commercially later this year. Read more: Novartis earnings fall but new drug raises hopes The contract is for the supply of lentiviral vectors, which are used to generate CTL019, a treatment for an especially difficult type of leukaemia. Novartis has flagged the treatment as a potential blockbuster. The supply agreement is for the next three years, with the potential of an extension to five years, and it includes a $10m upfront payment for Oxford BioMedica. John Dawson, the boss of Oxford BioMedica, said: The new deal with Novartis will strengthen the group's balance sheet immediately and will support the group's continued growth over the next three years. The company is also set to receive royalty payments on future sales of CTL019, which analysts at Jefferies said could earn Oxford BioMedica between 65-75m a year assuming peak sales of … Continue reading →

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Gene Therapy 2016-2026 – Technologies, Markets and Companies Report 2017 – Profiles of 189 Companies with 240 … – Business Wire (press release)

Posted: Published on July 9th, 2017

DUBLIN--(BUSINESS WIRE)--Research and Markets has announced the addition of Jain PharmaBiotech's new report "Gene Therapy - Technologies, Markets and Companies" to their offering. Gene therapy technologies are described in detail including viral vectors, nonviral vectors and cell therapy with genetically modified vectors. Gene therapy is an excellent method of drug delivery and various routes of administration as well as targeted gene therapy are described. There is an introduction to technologies for gene suppression as well as molecular diagnostics to detect and monitor gene expression. The markets for gene therapy are difficult to estimate as there is only one approved gene therapy product and it is marketed in China since 2004. Gene therapy markets are estimated for the years 2016-2026. The estimates are based on epidemiology of diseases to be treated with gene therapy, the portion of those who will be eligible for these treatments, competing technologies and the technical developments anticipated in the next decades. In spite of some setbacks, the future for gene therapy is bright. The markets for DNA vaccines are calculated separately as only genetically modified vaccines and those using viral vectors are included in the gene therapy markets The voluminous literature on gene therapy was reviewed … Continue reading →

Posted in Gene Therapy | Comments Off on Gene Therapy 2016-2026 – Technologies, Markets and Companies Report 2017 – Profiles of 189 Companies with 240 … – Business Wire (press release)

Shire submits investigational New Drug Application to FDA for Gene … – GlobeNewswire (press release)

Posted: Published on July 9th, 2017

July 06, 2017 07:00 ET | Source: Shire Pharmaceuticals Group Shire submits investigational New Drug Application to FDA for Gene Therapy candidate SHP654 for treatment of Hemophilia A SHP654 aims to deliver sustained protection against bleeds for patients with hemophilia A Lexington, Mass.-July 6, 2017- Shire plc (LSE: SHP, NASDAQ: SHPG), the leading biotechnology company focused on serving people with rare diseases, today announcedthe submission of an investigational new drug (IND) application to the U.S. Food and Drug Administration (FDA) for SHP654, also designated as BAX 888, an investigational factor VIII (FVIII) gene therapy for the treatment of hemophilia A. SHP654 aims to protect hemophilia A patients against bleeds through the delivery of a long-term, constant level of factor expression.1 The IND filing for SHP654 represents the latest step forward for Shire's gene therapy program, which shows promise for both hemophilia A and B populations. "Shire is leveraging decades of scientific leadership in hemophilia to advance research in gene therapy for this community," said Paul Monahan, M.D., Senior Medical Director, Gene Therapy, Shire. "Drawing from our rich heritage, Shire is well equipped to sustainably support the development of gene therapies that aim to advance current standards of care and minimize … Continue reading →

Posted in Gene Therapy | Comments Off on Shire submits investigational New Drug Application to FDA for Gene … – GlobeNewswire (press release)

Herb may help reduce menopausal symptoms – Idaho State Journal

Posted: Published on July 8th, 2017

Treating menopausal symptoms is difficult in our current medical-legal quite confusing environment that seems to produce nothing but mixed data and differing opinions. It is always nice to see an alternative to hormone replacement therapy getting some data behind it as to its effectiveness. There is quite an array of "natural" remedies available out there, but very few have good clinical data as to their effectiveness. One supplement that has been used by alternative practitioners for a number years to treat menopausal symptoms such as anxiety, hot flashes, night sweats, mood changes, and joint pain is Fennel. Fennel, as Im sure a number of you know, is an herb used in cooking. Fennel has essential oils and phytoestrogenic properties that give it a wonderful flavor, as well as its potential benefit in treating menopausal symptoms. A recent study published in the North American Menopause Society online journal Menopause showed that, compared to placebo, this herb greatly reduced menopausal symptoms, as listed above, when used as a method of intervention. As there are so many mainstream and alternative treatments for menopause and menopausal symptoms, its important that you sit and discuss potential interventions with your doctor to ensure there are no … Continue reading →

Posted in Hormone Replacement Therapy | Comments Off on Herb may help reduce menopausal symptoms – Idaho State Journal

8 Health Issues You Had No Idea Transgender and Gender-Diverse People Are Dealing With – Women’s Health

Posted: Published on July 8th, 2017

Women's Health 8 Health Issues You Had No Idea Transgender and Gender-Diverse People Are Dealing With Women's Health While there are some resources online, many people simply have to search online for doctors that offer hormone replacement therapy (aka HRT). The World Professional Association for Transgender Health has a provider database you can search to find a ... and more » Read more: 8 Health Issues You Had No Idea Transgender and Gender-Diverse People Are Dealing With - Women's Health … Continue reading →

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Chemotherapy could trigger spread of cancer, research suggests – Blasting News

Posted: Published on July 8th, 2017

Scientists warn that chemotherapy could #Trigger more aggressive tumors and spread cancer cells. This kind of therapy could shrink tumors but when the cells migrate to other parts of the human body, they are almost always deadly. According to The Telegraph, George Karagiannis from Albert Einstein College of Medicine of Yeshiva University, New York found out that the number of #Cancer Cells in mice with breast cancer has increased in their body and in the lungs after undergoing chemotherapy. The medication used in the treatment is thought to trigger a repair mechanism in the body. However, this allows tumors to grow back stronger and more aggressive. In addition, the process of giving toxic medication to the body will also increase the number of doorways on the blood vessel which will allow cancer to spread. Dr. Karagiannis research has revealed that at least 20 patients have had an increased number of doorways after receiving two chemotherapy drugs. He suggests that health practitioners should be vigilant in monitoring if cancer cells are beginning to circulate. They also need to check if new doorways are emerging. The process of checking could be done by obtaining a small amount of the tumor after a … Continue reading →

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Man Uses BJJ To Treat Paralysis – Jiu-Jitsu Times

Posted: Published on July 8th, 2017

Normally, Jiu Jitsu is used as a self-defense method. Houston resident, Maximiliano Ulloa-York, had found Jiu Jitsu to also be an effect therapeutic method to treat his paralysis. The full story may be found onABC 13. Maximiliano already had over a decade of martial arts experience prior to his first injury in 1998 that he had suffered at work. He had survived an accidental cut to his leg with a skill saw whilst on the job and only survived because it missed a major artery. He went from having a limp to being a fully-functional athlete in a matter of months. With his latest spinal cord injury, which he had suffered after falling from a two-story building, he is once again using the same Jiu Jitsu exercises to restore himself. Although he cannot use his abdomen, legs, or lower back, he is becoming stronger in the other parts of his body that are still functional. He started the IJJWLF to encourage other disabled individuals to get started with Jiu-Jitsu. Go here to read the rest: Man Uses BJJ To Treat Paralysis - Jiu-Jitsu Times … Continue reading →

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Jermichael Finley Says Leaving Football Is Hard But Coming Back … – Deadspin

Posted: Published on July 8th, 2017

Last week, after former Ravens linebacker Zach Orr announced he hoped to return to the NFL just five months after retiring with a congenital spine condition, ex-Packer Jermichael Finley said that Orrs story hits very close to home. Finley played six seasons as a tight end in Green Bay but retired following the 2013 season, at age 27, after he sustained a concussion and a serious neck injury in a span of four weeks. In May, Finley wrote an essay for The Players Tribune in which he detailed the circumstances of his concussion history, his career-ending injuries, his retirement, and the hardships of the adjustment to post-football living. Finley has since expanded on that essay in interviews with NPR and ESPN. I spoke to Finley by phone this week. What follows is a transcript of our conversation, which has been edited and condensed for clarity. Why does Zach Orrs situation hit so close to home for you? Hes coming back to the NFL, especially with a spinal cord injuryits not like its an ACL or a knee sprain, or things like that you can come back from. A spinal cord injury scares me. I went through it. I know the … Continue reading →

Posted in Spinal Cord Injury Treatment | Comments Off on Jermichael Finley Says Leaving Football Is Hard But Coming Back … – Deadspin

ADS-5102 (Amantadine) – Parkinson’s News Today

Posted: Published on July 8th, 2017

ADS-5102 (amantadine) is a Parkinsons disease treatment developed byAdamas Pharmaceuticals. The company created the drug to reduce the dyskinesia, or involuntary movements, caused by another Parkinsons treatment,levodopa. ADS-5102 is also aimed at reducing the time during the day when Parkinsons symptoms return between doses of medication. U.S. regulators have yet to approve the therapy, which is in the clinical-trial stage. The active component in ADS-5102 is amantadine hydrochloride. Amantadine is a glutamate antagonist, or molecule that inhibits the action of the neurotransmitter glutamate. Neurotransmitters send signals between brain cells. One of the biological processes that glutamate plays a role in is movement. It passes signals from the brain to muscles by interacting with NMDA receptors on the outside of cells. Continuous use of levodopa over a long period can lead to an increase in glutamate signaling,disrupting motor control messages. The result is a Parkinsons patient experiencing involuntary movements. ADS-5102 blocks glutamates access to the NMDA receptors. This reduces the level of signaling and therefore the level of involuntary movement. Adamas formulated the drug for extended release, which means that its levels in the blood increase over time. By administering the treatment before bedtime, the levels gradually increase to their highest … Continue reading →

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Risking her life to save it: Local woman tries stem cell transplant to … – WKYC-TV

Posted: Published on July 8th, 2017

Local woman trying experimental treatment to stop debilitating disease Monica Robins, WKYC 12:11 AM. EDT July 06, 2017 (Photo: Submitted by Chelsea Jennings) Chelsea Jennings uses yoga to stay centered. Its teaching keep her positive, which is important for for someone about to risk her live to save it. She's only 26 and facing a rapidly progressing debilitating disease that will likely put her in a wheelchair within a year. As a new mom, she won't accept that. That's why she's risking her life for an experimental treatment that could possibly cure her disease. Her motivation to try an experimental stem cell transplant to control her multiple sclerosis? Her 18-month-old son Camden and husband Jeff. "I understand that there is an extreme risk, but if the medication is not working for me I cannot just slowly deteriorate in front of my family, my son," Chelsea says. "I cannot have that happen." Diagnosed five years ago, Chelsea tried every MS medication available, but couldn't tolerate them. She researched alternatives and found Dr. Richard Burt at Northwestern University who performs hematopoietic stem cell transplantation for MS. Last month, she went in for testing and was approved. Unfortunately it's not covered by her … Continue reading →

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