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Puma Biotechnology Inc (PBYI) Pops 60% on FDA Review – Investorplace.com

Posted: Published on May 25th, 2017

By Robert Martin, InvestorPlace Writer|May 22, 2017, 11:12 am EDT Puma Biotechnology Inc (NASDAQ:PBYI) jolted as much as 80% higher on Monday morning on news that theU.S. Food & Drug Administration posted a seemingly positive review of Pumas breast cancer drug, neratinib, ahead of an official vote Wednesday. PBYI then settled back to just 60% gains a few hours into the trading day. The FDA asked a few questions and raised a few concerns, notably, tolerability of neratinib in this patient population is a concern given the frequent dose interruptions, reductions, and discontinuations observed, mostly due to diarrhea. Specifically, 95% of patients in clinical trials suffered from diarrhea, with 40% of those suffering the grade 3 form of the side effect. However, on the whole, PBYI investors seemed pleased with what the FDA did (and didnt) ask, taking the review as an encouraging sign ahead of the companys Oncologic Drugs Advisory Committee meeting, scheduled for Wednesday. Neratinib (PB272) is being tested for the extended adjuvant treatment of HER2-positive early stage breast cancer. The drug is meant for patients who have already received Herceptin. The FDA preview said that the primary analysis showed an improvement with neratinib, and that despite changes … Continue reading →

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BBP: A Diversified Biotech ETF – Seeking Alpha

Posted: Published on May 25th, 2017

While 2017 has been a pretty good year overall for biotechs, the two largest ETFs in the space - the iShares Nasdaq Biotechnology ETF (NASDAQ:IBB) and the SPDR S&P Biotech ETF (NYSEARCA:XBI) - are up 10% and 17%, respectively. It's tough to forget that both of these funds are still about 25% off of their 2015 highs. IBB, which is heavily influenced by the largest biotech names, has been impacted by 50% drops in Gilead (NASDAQ:GILD) and Biogen (NASDAQ:BIIB). XBI has a much more diversified all-cap mix but has experienced similar results. But not all news coming out of the sector is bad. In fact, one biotech ETF has been downright ripping it since its launch at the end of 2014. The BioShares Biotechnology Products ETF (NASDAQ:BBP), which invests in companies that have at least one primary product that has received FDA approval, is up roughly 42% since its inception at the end of 2014 compared to a loss of 4% for IBB during the same time frame. IBB Total Return Price data by YCharts As fund advisor Virtus says on its website, companies that the fund invests in are "typically more established companies with much clinical trial failure risk … Continue reading →

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Same-sex couples argue in court to be on children’s birth certificates – USA TODAY

Posted: Published on May 25th, 2017

Stephanie Wang, The Indianapolis Star Published 1:26 p.m. ET May 23, 2017 | Updated 3:45 p.m. ET May 23, 2017 LGBT people have gained more legal recognition in recent years, but LGBT rights remain a central issue in Indiana politics. Stephanie Wang/IndyStar Jackie and Lisa Phillips-Stackman hold their daughter, Lola, on Dec. 4, 2015, at their Indianapolis home, The couple joined a lawsuit against Indiana to try to get the state to recognize both same-sex parents on their children's birth certificates.(Photo: Michelle Pemberton, The Indianapolis Star) A panel of three appeals-court judges are examiningwhether Indiana discriminates by not recognizing two married women both as parents on their children's birth certificates. Judge Diane S. Sykes of the 7th U.S. Circuit Court of Appeals in Chicago drew distinctions Monday between biological parentage and parental rightsand which of the two should be represented on birth certificates. "You can't overcome biology," Sykes said. "If the state defines parenthood by virtue of biology, no argument under the (Constitution's) Equal Protection Clause or the substantive due process clause can overcome that." "Your Honor, with all due respect, we maintain that parenthood is no longer defined by biology," said Karen Celestino-Horseman, the lawyer for eight same-sex couples … Continue reading →

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Judge to Indiana same-sex couples: ‘You can’t overcome biology’ – The Courier-Journal

Posted: Published on May 25th, 2017

LGBT people have gained more legal recognition in recent years, but LGBT rights remain a central issue in Indiana politics. Stephanie Wang/IndyStar Jackie and Lisa Phillips-Stackman hold their daughter, Lola, at their Indianapolis home, Friday, Dec. 4, 2015. The couple are filing a lawsuit against the state to try to get Indiana to recognize both same-sex parents on their children's birth certificates.(Photo: Michelle Pemberton/The Star) In oral arguments Monday, a panel of three judges for the Seventh Circuit Court of Appeals examined whetherIndiana discriminates by not recognizing two married women both as parents on their children's birth certificates without having to adopt. Judge Diane S. Sykesdrew distinctions betweenbiological parentage and parental rights, and which of the two should be represented on birth certificates. "You can't overcome biology," Sykes said. "If the state defines parenthood by virtue of biology, no argument under the Equal Protection Clause or the substantive due process clause can overcome that." "Your Honor, with all due respect, we maintain that parenthood is no longer defined by biology," said Karen Celestino-Horseman, the attorney for eight same-sex couples who brought the lawsuit against the state for only allowing only a mother and a father to be named on birth … Continue reading →

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Professor sheds light on plant biology – Cayman Compass

Posted: Published on May 25th, 2017

Dr. Martina Kniger, adjunct assistant professor of biological sciences at Wellesley College in the U.S. spoke on Monday at the Southern Cross Club as a guest lecturer in a recurring Reef Lecture Series, organized by the Central Caribbean Marine Institute. Dr. Knigers research and her presentation focused on the physiological and cellular mechanisms that allow plants to deal with light intensities that vary dramatically. I have been coming to CCMI for seven years now to teach an introductory tropical biology class for Wellesley College students, Dr. Kniger said in a press release. The students take a lecture class in the spring semester at Wellesley College to get prepared for this trip. Being at CCMI provides a unique opportunity to explore both the marine and terrestrial environments of this beautiful island and allows my students to develop their own research ideas. They not only explore different aspects of reef biology, but also investigate how plants manage to survive and thrive in this dry and hot environment. Many of the students who have participated in this course have greatly benefitted from this opportunity and have gone on to get PhDs in marine biology or other areas of biology. The target species of … Continue reading →

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American Oriental Bioengineering, Inc. (AOBI) Upgraded to Hold by ValuEngine – Sports Perspectives

Posted: Published on May 25th, 2017

American Oriental Bioengineering, Inc. (AOBI) Upgraded to Hold by ValuEngine Sports Perspectives ValuEngine upgraded shares of American Oriental Bioengineering, Inc. (OTCMKTS:AOBI) from a sell rating to a hold rating in a research note issued to investors on Wednesday morning. American Oriental Bioengineering (OTCMKTS:AOBI) remained flat at ... See the article here: American Oriental Bioengineering, Inc. (AOBI) Upgraded to Hold by ValuEngine - Sports Perspectives … Continue reading →

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Grey's Anatomy Season 14 Details – POPSUGAR

Posted: Published on May 25th, 2017

Grey's Anatomy Season 14 Is Shaping Up to Be Pretty Dramatic Even though we only just witnessed the season 13 finale of Grey's Anatomy, it's never too soon to look ahead. In the wake of everything that has happened, it's clear there are plenty of planted seeds that will surely bloom once the show returns in the Fall. Granted, Stephanie will no longer be with us, but with a few new faces, a couple of new flames, and that trademark drama we've always loved, there's plenty to look forward to. There isn't much available information about the 14th season of Grey's, but we do have potential things figured out. Owen's sister is alive! At the very end of the finale, Owen reconnects with his long-lost sibling, Megan. This could cause all kind of upheaval. It will certainly change Owen's entire life. Then there's Riggs, who was in love with Megan before she vanished. The timing is terrible: Meredith has just opened herself up romantically to Riggs, and now she risks losing him. Will Megan and Riggs be able to pick up where they left off? There's also a chance Megan will join the ranks at Grey Sloan Memorial Hospital. Once … Continue reading →

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Anatomy of a hunger strike – News24

Posted: Published on May 25th, 2017

On May 10th the Ahmed Kathrada Foundation issued a statement by its late founders fellow former Robben Islander, 86-year old Laloo Isu Chiba, that called on South Africans to join a 24-hour food strike in solidarity with the more than thousand Palestinian political prisoners on hunger strike for improved prison conditions. The prisoners demands include the right to higher education study, appropriate medical care, and an end to solitary confinement, imprisonment without trial and the denial of family visits. As a prisoner on Robben Island for 18 years from 1964, and a detainee subsequently under South Africas 1985 State of Emergency, these demands have a painful echo for Isu and his own hunger strikes to improve prison conditions. I am duty bound today to support the Palestinians who are in the same condition that we were in all those years ago, Isu says in the statement by the foundation. And he adds in conversation with me that he cannot but feel for political prisoners held fundamentally unjustly anywhere in the world. I had the privilege of being detained with Isu for the length of the 1985/86 State of Emergency, and participated with him in two hunger strikes at Johannesburg Prison. … Continue reading →

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Brain anatomy differs in people with 22q genetic risk for … – Medical Xpress

Posted: Published on May 25th, 2017

May 24, 2017 White matter fiber architecture of the brain. Credit: Human Connectome Project. A UCLA study characterizes, for the first time, brain differences between people with a specific genetic risk for schizophrenia and those at risk for autism, and the findings could help explain the biological underpinnings of these neuropsychiatric disorders. The research, published May 23 in the Journal of Neuroscience, sheds light on how an excess, or absence, of genetic material on a particular chromosome affects neural development. "Notably, the opposing anatomical patterns we observed were most prominent in brain regions important for social functioning," said Carrie Bearden, lead author of the study and a professor of clinical psychology at UCLA. "These findings provide clues into differences in brain development that may predispose to schizophrenia or autism." Bearden's earlier research had focused on children with abnormalities caused by missing sections of genetic material on chromosome 22, in a location known as 22q11.2. The disorder, called 22q11.2-deletion syndrome, can cause developmental delays, heart defects and distinct facial features. It also confers the highest-known genetic risk for schizophrenia. Then she learned that people with 22q duplicationabnormal repetition, or duplication, of genetic material in chromosome 22had learning delays and sometimes autism, … Continue reading →

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5 Things You Should Never Say to Someone With Eczema – Eczema … – Health.com

Posted: Published on May 24th, 2017

Dealing with eczema is hard enough on its own. But because the skin conditionwhich causes an itchy, red, painful rashis so visible, people with eczema often also have to cope with insensitive comments from those around them. As a result, the condition can take a real emotional toll in addition to the already-frustrating physical symptoms. "[Eczema] really doesn't help in terms of the patient's emotional wellbeing and confidence," says Gil Yosipovitch, MD, professor of medicine at the University of Miami Miller School of Medicine and author of Living With Itch ($19; amazon.com). We asked people to weigh in on how you can be more thoughtful when it comes to talking about skin symptoms (if you have to say anything at all). Here, five things you should never say to someone with eczema (or any skin condition, for that matter). Karina, 24, a medical student in Brooklyn, N.Y. who has had eczema since she was a child, tells us she was asked this question often growing up. "It's really a frustrating thing when you're a kid, and you don't even understand it much [yourself]," she says. "It's really hard to be confident." Eczema is not contagious. Although experts don't know exactly … Continue reading →

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