UC Riverside-led mouse study shows the ligand indazole chloride improves motor function, imparting therapeutic benefits even when treatment is initiated at the peak of disease By Iqbal Pittalwala on December 1, 2014 Seema Tiwari-Woodruff is an associate professor of biomedical sciences at the UC Riverside School of Medicine. Photo credit: I. Pittalwala, UC Riverside. RIVERSIDE, Calif. Multiple sclerosis (MS), an autoimmune disease of the brain and spinal cord, affects about 2.3 million people worldwide (400,000 in the United States). Affecting more women than men, it can be seen at any age, although it is most commonly diagnosed between the ages of 20 and 40. An unpredictable disease that disrupts the flow of information within the brain and between the brain and the body, MS is triggered when the immune system attacks the myelin sheath, the protective covering around the axons of nerve fibers. The demyelination that follows causes a disruption of nerve impulses. As the protective sheath best imagined as the insulating material around an electrical wire wears off, the nerve signals slow down or stop, and the patients vision, sensation and use of limbs get impaired. Permanent paralysis can result when the nerve fibers are completely damaged by the … Continue reading
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