Rice University bioengineers have found new evidence of a possible link between diabetes and the hardening of heart valves. A Rice lab, in collaboration with the University of Texas (UT) Medical School at Houston, discovered that the interstitial cells that turn raw materials into heart valves need just the right amount of nutrients for proper metabolic function. The surprise was that feeding them too much glucose, a sugar, slowed the cells down. Diabetes is a metabolic disease characterized by high blood-sugar levels over a long period; a 2006 study of atherosclerosis by University of Washington researchers found a correlation between diabetes and aortic-valve calcification. In the new work by the lab of Jane Grande-Allen of Rices bioengineering department, recently ranked No. 5 in the nation by U.S. News & World Report, researchers have directly seen the effect of high blood-sugar levels on heart-valve cell metabolism for the first time. The study appears this month in the Journal of the Royal Society Interface. The most significant result of the study is that high glucose concentration can actually be detrimental to the aortic-valve cells and their behavior in interacting with the extracellular matrix, said lead author Peter Kamel, who carried out the … Continue reading
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