PUBLIC RELEASE DATE: 8-May-2014 Contact: Sonia Furtado Neves pressoffice@embl.de 49-622-138-78263 European Molecular Biology Laboratory Hinxton, 8 May 2014 Researchers at the European Bioinformatics Institute (EMBL-EBI) and the Wellcome Trust Sanger Institute have discovered that some immune cells turn themselves off by producing a steroid. The findings, published in Cell Reports, have implications for the study of cancers, autoimmune diseases and parasitic infections. If you've ever used a steroid, for example cortisone cream on eczema, you'll have seen first-hand how efficient steroids are at suppressing the immune response. Normally, when your body senses that immune cells have finished their job, it produces steroids but which cells actually do that? In this latest study, scientists looked at Th2 immune cells during parasitic infection and saw that at a certain point, these cells produce a steroid called pregnenolone. "We were really surprised to see that these immune cells are producing a steroid. In cell culture, we see that the steroids play a part in regulating T cell proliferation," says Bidesh Mahata in the Teichmann group at EMBL-EBI and Sanger, who designed the study. "We had already seen that T-helper cells were producing steroids, but initially we were blind what was going on?" "Because … Continue reading
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