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S.A. prof patents discovery that combats brain injury

Posted: Published on January 9th, 2014

SAN ANTONIO A local cellular and structural biology professor has patented a new way to treat traumatic brain injury, the University of Texas Health Science Center at San Antonio announced Wednesday. Professor James Lechleiter received a U.S. patent last week for his discovery that two compounds called 2-methylthio-ADP and MRS2365 stimulate the brain's caretaker cells to reduce swelling inside the skull, according to a news release. The caretaker cells are called astrocytes. Lechleiter and associate neurosurgery professor Dr. Murat Digicaylioglu have published research that showed treating astrocytes with the two compounds in a brain-injured mouse significantly reduced swelling, according to the release. Yet-to-be-published research found similar results in human brain tissue. With this treatment, astrocytes themselves, as well as neurons, live longer, Lechleiter said in a prepared statement. It is hoped these preliminary studies will soon lead to a new class of safe and effective drugs that can be administered if a traumatic brain injury, even a mild one, is suspected to have occurred. jlloyd@express-news.net Twitter: @jlloydster Here is the original post: S.A. prof patents discovery that combats brain injury … Continue reading →

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Multiple Sclerosis Causes, Symptoms, Treatment – Multiple …

Posted: Published on January 9th, 2014

Multiple Sclerosis (cont.) Medical Author: Melissa Conrad Stppler, MD, is a U.S. board-certified Anatomic Pathologist with subspecialty training in the fields of Experimental and Molecular Pathology. Dr. Stppler's educational background includes a BA with Highest Distinction from the University of Virginia and an MD from the University of North Carolina. She completed residency training in Anatomic Pathology at Georgetown University followed by subspecialty fellowship training in molecular diagnostics and experimental pathology. Medical Editor: Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications. The symptoms of multiple sclerosis can be different from person to person. Visual, sensory, and motor signs and symptoms are all part of multiple sclerosis. The clinical manifestations are varied, and therefore there is a wide range of symptoms that can appear. Some people have mild cases of … Continue reading →

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Hormone therapies help older adults find new life

Posted: Published on January 9th, 2014

By Erinn Hutkin, Special to U-T San Diego 6 a.m.Jan. 7, 2014 Dr. Brenda Marshall, who has an integrated medicine practice in Solana Beach, said she knows one person in particular who has benefited greatly from hormone replacement therapy. He was reluctant at first to try the treatment to make up for low testosterone and other hormones in the body that decrease with age, but at more than 80 years old, he was getting heavier and moving slower. After just three weeks of hormone therapy, she said, he was sleeping better and had more energy. Its like a new life for him, she said of the patient, who just happened to be her father. Balancing hormones can allow older people to be more functional. Although there may be resistance by some people to try treatments to create hormone balance, physicians like Marshall are strong believers that using therapy to make up for lost hormones in both men in women mainly estrogen, progesterone and testosterone can bring new life to many patients. Treatments for balancing hormones can vary from changing ones diet to learning to manage stress to supplementing hormones that are depleted. The key, she said, is to make sure … Continue reading →

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The American Academy of Anti-Aging Medicine (A4M) Concludes Successful Year and Looks Forward to Prestigious …

Posted: Published on January 9th, 2014

Boca Raton, FL (PRWEB) January 07, 2014 The year 2013 offered unparalleled education, distinguished speakers, informative exhibits, hundreds of Fellowship graduates and knowledge used to eliminate chronic diseases, one diagnosis at a time. In 2013, A4M offered 11 live U.S. events and 12 events held overseas. In the course of a year, the U.S. events included three Bio-Identical Hormone Replacement Therapy (BHRT) Symposiums held in Las Vegas, San Diego, and Boston; an Inflammation Symposium offered in Fort Lauderdale, FL; an IV Symposium in Dallas TX; Gut/ Brain Symposium in Los Angeles, CA; and two Annual World Congresses held in Orlando, FL and Las Vegas, NV. Over 15,000 healthcare practitioners attended an A4M educational event in 2013. The 21st Annual Spring World Congress in Anti-Aging & Regenerative Medicine at the Gaylord Palms Resort in Orlando, FL was held April 11-14, 2013. Over 2,500 medical professionals from all over the world gathered for pre-conference workshops, Fellowship modules, the exhibit hall, board certification exams, three days of general conference sessions, distinguished speakers and medical faculty. Among keynote speakers was Pat Williams, co-founder and senior vice president of the Orlando Magic who spoke on the 7 Key Ingredients to Make a Great Leader. The … Continue reading →

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Exploitation Of Menopausal Women

Posted: Published on January 9th, 2014

BRISDELLE, the latest drug by Noven, is set to medicalize yet another normal phase of womens lives, potentially causing more harm than good. Hastily approved by the FDA, and after overriding the advice of the drug advisory committee, BRISDELLE is billed as the first and only FDA approved non-hormonal therapy for moderate to severe hot flashes associated with menopause. Marketed as non-hormonal, the drugs advertising alludes to the practice of hormone replacement therapy, which was in wide-use until non-hormonal drugs were proven to increase the occurrence of heart attacks, strokes, blood clots, and even breast cancer. As a result of these dangers, few women continue to use hormone replacements. Noven, in an attempt to fill the void in hormone replacement usage, labels their drug as a hot flash reducer, an antidepressant, and a treatment for such conditions as OCD, panic, social anxiety, and posttraumatic stress. In March of 2013, an FDA advisory committee met to review the effectiveness and safety of BRISDELLE, and determined that not only did the drug fail to show any significant benefits to the patients over the placebo product, but it actually increased the dangers of adverse side effects such as seizures, convulsions, manic episodes, and … Continue reading →

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Stem cell research identifies new gene targets in patients with Alzheimer’s disease

Posted: Published on January 9th, 2014

PUBLIC RELEASE DATE: 8-Jan-2014 Contact: David McKeon DMckeon@nyscf.org 212-365-7440 New York Stem Cell Foundation NEW YORK, NY (January 8, 2014) Scientists at The New York Stem Cell Foundation (NYSCF) Research Institute in collaboration with scientists at the Icahn School of Medicine at Mount Sinai (ISMMS) successfully generated a stem cell model of familial Alzheimer's disease (FAD). Using this stem cell model, researchers identified fourteen genes that may be implicated in the disease and one gene in particular that shows the importance that inflammation may play in the brain of Alzheimer's patients. In this study, published today in PLOS ONE, the team of scientists produced stem cells and neural precursor cells (NPCs), representing early neural progenitor cells that build the brain, from patients with severe early-onset AD with mutations in the Presenilin 1 (PSEN1) gene. These NPCs had elevated Abeta42/Abeta40 ratios, indicating elevation of the form of amyloid found in the brains of Alzheimer's patients. These levels were greater than those in adult cells that did not have the PSEN1mutation. This elevated ratio showed that these NPCs grown in the petri dish were accurately reflecting the cells in the brains of FAD patients. "Our ability to accurately recapitulate the disease in … Continue reading →

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Breakthrough Research Provides Valuable Insight On Cause Of Alzheimer’s

Posted: Published on January 9th, 2014

New York, NY (PRWEB) January 08, 2014 A stem cell model of familial Alzheimers disease (FAD) was successfully generated, allowing researchers to identify 14 genes potentially implicated in the disease. One gene in particular demonstrates the important role inflammation may play in the brain of Alzheimers patients. The study was completed by scientists at The New York Stem Cell Foundation (NYSCF) Research Institute in collaboration with scientists at the Icahn School of Medicine at Mount Sinai (ISMMS) and funded in part by the Cure Alzheimers Fund(CAF). In the study published today in PLOS ONE, a team of scientists produced stem cells and neural precursor cells (NPCs), representing early neural progenitor cells that build the brain from patients with severe early-onset AD with mutations in the Presenilin 1 (PSEN1) gene. These NPCs had elevated Abeta42/Abeta40 ratios, indicating elevation of the form of amyloid found in the brains of Alzheimers patients. These levels were greater than those in adult cells that did not have the PSEN1 mutation. This elevated ratio shows that the NPCs grown in the petri dish accurately reflected the cells in the brains of FAD patients. "The gene expression profile from the familial Alzheimers stem cells points to inflammation, … Continue reading →

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New gene targets for Alzheimer’s patients found

Posted: Published on January 9th, 2014

New York, Jan 9 : Using a new stem cell model, researchers have identified 14 genes that may be implicated in familial Alzheimer's disease (FAD). One gene in particular shows the importance that inflammation may play in the brain of Alzheimer's patients, said a study. Scientists at the New York Stem Cell Foundation (NYSCF) research institute, in collaboration with scientists at the Icahn School of Medicine at Mount Sinai (ISMMS), have successfully generated a stem cell model of FAD. "These genes provide us with new targets to help elucidate the cause of sporadic forms of the disease as well provide targets for the discovery of new drugs," said Susan L. Solomon, chief executive officer of the New York Stem Cell Foundation. The team of scientists produced stem cells and neural precursor cells (NPCs), representing early cells that build the brain, from patients with severe early-onset Alzheimer's with mutations in the Presenilin 1 (PSEN1) gene, said the study that appeared in the journal PLOS ONE. "The gene expression profile from stem cells points to inflammation which is especially exciting because we would not usually associate inflammation with this particular Alzheimer's gene," added Sam Gandy, director of the centre for cognitive health … Continue reading →

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Rare genetic mutation discovered in Tourette syndrome family

Posted: Published on January 9th, 2014

Health Linda Carroll NBC News contributor 21 hours ago A rare genetic mutation that disrupts the production of histamine may help researchers unravel the mystery that surrounds Tourette syndrome. The mutation discovered by Yale researchers can cause the kinds of tics and other abnormalities that are the hallmark of the syndrome, according to a study published Wednesday in the journal Neuron. Thus far the genetic anomaly has been discovered only in nine members of a single family: a father and all eight of his children who have both the mutation and Tourette syndrome. We know that Tourette is about 90 percent genetic, said study coauthor Dr. Christopher Pittenger, an associate professor of psychiatry and psychology at the Yale University School of Medicine and director of the Yale OCD research clinic. But its been incredibly hard to find any genetic abnormalities that cause the syndrome. We have proven that this gene really is the cause of Tourette in this family and also looked at some of its downstream effects. Courtesy Jeffrey Kramer Jeffrey Kramer and his three sons. Kramer and two of his grown-up sons have been living with Tourette for decades. Hes excited by the new findings, but realistic about … Continue reading →

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Mapping the Qatari shows way to prevention of inherited diseases

Posted: Published on January 9th, 2014

(MENAFN - Muscat Daily) A Weill Cornell Medical College study that analysed the DNA of Qatar's native population has discovered genetic variations that could help doctors target interventions to reduce the prevalence of a variety of debilitating hereditary disorders Researchers at Weill Cornell Medical College in Qatar (WCMC-Q) and Weill Cornell Medical College in New York (WCMC-NY), working with colleagues from Cornell University in Ithaca and Hamad Medical Corporation, identified 37 genetic variants in 33 genes known to play causal roles in a total of 36 diseases, including such devastating conditions as cystic fibrosis, sickle cell anemia and muscular dystrophy. The study points the way to more comprehensive screening for a host of inherited diseases, which could significantly reduce their incidence. The project titled, 'Exome Sequencing Identifies Potential Risks Variants for Mendelian Disorders at High Prevalence in Qatar' sequenced the DNA of 100 Qatari nationals representing the three major ethnic subgroups of the country the Bedouin (termed Q1 for the purposes of the study), those of Persian-South Asian descent (Q2), and those of African descent (Q3). By analysing the individuals' exomes important sections of the DNA containing the code that is translated into proteins and comparing them to the genetic … Continue reading →

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