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News Review From Harvard Medical School — More Details in Long-Term Hormone Study

Posted: Published on October 3rd, 2013

October 2, 2013 News Review From Harvard Medical School -- More Details in Long-Term Hormone Study Results of a new, longer-term study confirm that women should not take hormone replacement therapy to reduce any disease risk after menopause. But short-term treatment for menopause symptoms seems to be safe. The new results are consistent with advice doctors have been giving for about a decade. The new study is a follow-up to the Women's Health Initiative. That study changed medical practice when it was published in 2002. The study was stopped early when it found that women who were randomly assigned to take estrogen and progestin had higher risks of breast cancer, heart attack, stroke and blood clots. They were compared with women taking placebo (fake) pills. A study of women taking estrogen alone found a slightly higher risk of blood clots and stroke. The new study looked at the women's health after 13 years. It clarified some risks for younger women in the study, those ages 50 to 59. Younger women who were in the estrogen-only study had a slightly lower rate of heart attack and fewer deaths than women who took placebo pills. But blood-clot rates were higher for women … Continue reading →

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Hormone replacement therapy likely safe for women short-term, study finds

Posted: Published on October 3rd, 2013

US Treasury warns of harm from debt default US Treasury warns of harm from debt default The U.S. Treasury Department is warning that the economy could plunge into a downturn worse than the Great Recession if Congress fails to raise the federal borrowing limit and the country defaults on its debt...Full Story > The U.S. Treasury Department is warning that the economy could plunge into a downturn worse than the Great Recession if Congress fails to raise the federal borrowing limit and the country defaults on its debt obligations.Full Story > TN Highway Patrol: Bus was not overweight when it crashed, no charges yet TN Highway Patrol: Bus was not overweight when it crashed, no charges yet Updated: Thursday, October 3 2013 11:01 AM EDT2013-10-03 15:01:52 GMT Updated: Thursday, October 3 2013 10:58 AM EDT2013-10-03 14:58:59 GMT Updated: Thursday, October 3 2013 10:55 AM EDT2013-10-03 14:55:32 GMT After years of conflicting advice, a new study finds that healthy women can take drugs involved with hormone replacement therapy for a little while. Just don't take it long-term thinking HRT will prevent heart disease or cancer. In fact, taking it for a long period of time comes with risks. Hormone replacement therapy … Continue reading →

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New Analysis Confirms Hormone Therapy Won't Prevent Disease After Menopause

Posted: Published on October 3rd, 2013

By Amy Norton HealthDay Reporter TUESDAY, Oct. 1 (HealthDay News) -- No good evidence supports using hormone replacement therapy after menopause to prevent heart disease or other chronic ills, but short-term use for hot flashes should be an option. That's the conclusion of the latest analysis of the Women's Health Initiative (WHI), a group of major U.S. trials set up to test use of hormone replacement therapy for preventing chronic diseases in healthy, older women. The WHI was launched in the 1990s, at a time when doctors were prescribing hormone replacement therapy to postmenopausal women to ward off heart disease. The results changed common practice, however. In 2002, one of the trials was stopped early when researchers found that women taking the hormones -- estrogen-plus-progestin pills -- actually had higher risks of blood clots, heart attack, stroke and breast cancer than placebo users did. A second trial, looking at estrogen therapy alone, was stopped two years later. Women on the hormone showed no lower risk of heart disease, but did have a slightly elevated rate of blood clots and stroke. The latest findings, published in the Oct. 2 issue of the Journal of the American Medical Association, do nothing to … Continue reading →

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Review adds to hormone replacement therapy's risks, benefits

Posted: Published on October 3rd, 2013

A follow-up to one of the largest studies on postmenopausal women reveals that hormone replacement therapy (HRT) may not provide protective benefits against heart disease and other chronic conditions, and some forms might raise risk for certain diseases, like breast cancer. However, short-term hormone use for menopause-related conditions may still be beneficial. The new study, published Oct. 2 in JAMA, re-examined women from the Women's Health Care Initiative, a research program started in 1991 that involved nearly 162,000 postmenopausal women. The new analysis included data on the women 13 years after the landmark study was completed. During the initial study, the women either took a placebo, estrogen, or an estrogen and progestin combination treatment for five to seven years. Previously, doctors believed that hormonal treatments that use estrogen may be able to treat menopausal symptoms such as hot flashes and vaginal dryness, as well as provide protection against some conditions caused by aging like heart disease and bone loss. But, preliminary results from the Women's Health Care Initiative in 2002 showed that women taking an estrogen and progestin treatment had higher risks of blood clots, heart attacks, stroke and breast cancer compared to others taking a placebo. Research published two … Continue reading →

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Computer Scientists Develop New Approach to Sort Cells Up to 38 Times Faster

Posted: Published on October 3rd, 2013

Newswise A team of engineers led by computer scientists at the University of California, San Diego, has developed a new approach that marries computer vision and hardware optimization to sort cells up to 38 times faster than is currently possible. The approach could be used for clinical diagnostics, stem cell characterization and other applications. The approach improves on a technique known as imaging flow cytometry, which uses a camera mounted on a microscope to capture the morphological features of hundreds to thousands of cells per second while the cells are suspended in a solution moving at approximately 4 meters per second. The technique sorts cells into different categories, for example benign or malignant cells, based on their shape and structure. If these features can be calculated fast enough, the cells can be sorted in real-time. Previous techniques simply could not keep up with the image data streaming off of this high speed camera, said Ryan Kastner, a professor of computer science at the Jacobs School of Engineering at UC San Diego. This has to potential to lead to a number of clinical breakthroughs, and we are working closely with UCLA and their industrial partners to commercialize our technology. Other researchers … Continue reading →

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Computer scientists develop new approach to sort cells up to 38x faster

Posted: Published on October 3rd, 2013

A team of engineers led by computer scientists at the University of California, San Diego, has developed a new approach that marries computer vision and hardware optimization to sort cells up to 38 times faster than is currently possible. The approach could be used for clinical diagnostics, stem cell characterization and other applications. The approach improves on a technique known as imaging flow cytometry, which uses a camera mounted on a microscope to capture the morphological features of hundreds to thousands of cells per second while the cells are suspended in a solution moving at approximately 4 meters per second. The technique sorts cells into different categories, for example benign or malignant cells, based on their shape and structure. If these features can be calculated fast enough, the cells can be sorted in real-time. Previous techniques simply could not keep up with the image data streaming off of this high speed camera, said Ryan Kastner, a professor of computer science at the Jacobs School of Engineering at UC San Diego. This has to potential to lead to a number of clinical breakthroughs, and we are working closely with UCLA and their industrial partners to commercialize our technology. Other researchers had … Continue reading →

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New MRI technique can detect genetic condition that attacks the heart, brain and nerves

Posted: Published on October 3rd, 2013

Public release date: 2-Oct-2013 [ | E-mail | Share ] Contact: Raquel Maurier rmaurier@ualberta.ca 780-492-5986 University of Alberta Faculty of Medicine & Dentistry A genetic condition that attacks multiple organs and usually results in fatal heart problems can be detected using a new MRI technique that was developed at the University of Alberta. The discovery of this new diagnostic tool has resulted in updated clinical guidelines for the diagnosis and treatment of Fabry disease in Canada. Faculty of Medicine & Dentistry researchers Gavin Oudit and Richard Thompson worked with Faculty colleagues Kelvin Chow and Alicia Chan on the discovery, as well as Aneal Khan from the University of Calgary. The findings were recently published in the peer-reviewed journal, Circulation Cardiovascular Imaging, and involved 31 Alberta patients who have the disease. Thompson and trainee Chow developed the MRI technique known as T1 mapping which can detect heart damage and changes at early stages earlier than regular MRI scans or ultrasound. When this type of MRI is used on patients with Fabry disease, the scans can detect both the disease and the severity of damage to the heart. The T1 mapping method developed by Thompson's group can be easily programmed onto MRIs … Continue reading →

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New genetic discovery could reduce the guess work in drug dosing

Posted: Published on October 3rd, 2013

Oct. 1, 2013 The discovery of genetic differences affecting up to a third of the population could take the guesswork out of prescribing the correct dose of 25 percent of drugs currently on the market, researchers say. The scientists found two genetic variants that alter the activity level of an enzyme responsible for processing, or metabolizing, drugs ranging from the painkiller codeine to the breast cancer drug tamoxifen. The Ohio State University researchers who found these differences say that pending additional research, the variants are good candidates for inclusion in an existing biomarker test that guides drug dosing. The current test is designed to determine the enzyme's activity level, or expression, to predict whether a patient will fall into one of four categories: poor, intermediate, extensive or ultra-rapid metabolizer. Metabolism speed affects how much medicine a patient needs. But there are limits to the existing test: The current biomarker panel is based on variants that have been associated with how patients respond to different doses of drugs. The researchers who found these previously unidentified variants, however, have determined the specific effects that the variants have on drug metabolism. One reduces the enzyme's activity twofold by turning off a function of … Continue reading →

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Fibrocell Science to Present at 2013 Stem Cell Meeting on the Mesa

Posted: Published on October 3rd, 2013

EXTON, Pa.--(BUSINESS WIRE)-- Fibrocell Science, Inc. (NYSE MKT:FCSC), an autologous cell therapy company primarily focused on developing innovative products for skin diseases and conditions, announced today that David Pernock, Chairman and Chief Executive Officer, will present at the 3rd Annual Regenerative Medicine Partnering Forum, part of this years Stem Cell Meeting on the Mesa held October 14-16 in La Jolla, California. Mr. Pernock will provide a corporate overview during the live presentation on Monday, October 14 at 5:30 p.m. PT in the La Jolla Ballroom CD&E of the Estancia La Jolla Hotel. He will be joined by the companys Chief Financial Officer, Greg Weaver. Organized by the Alliance for Regenerative Medicine (ARM), the California Institute for Regenerative Medicine (CIRM) and the Sanford Consortium for Regenerative Medicine, the 2013 Stem Cell Meeting on the Mesa is a three-day conference aimed at bringing together senior members of the regenerative medicine industry with the scientific research community to advance stem cell science into cures. The Regenerative Medicine Partnering Forum, held October 14 &15 at the Estancia La Jolla Hotel & Spa, is the only partnering meeting organized specifically for the regenerative medicine and advanced therapies industry. The meeting also features a nationally recognized … Continue reading →

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Stem cells help repair traumatic brain injury by building a 'biobridge'

Posted: Published on October 3rd, 2013

Public release date: 3-Oct-2013 [ | E-mail | Share ] Contact: Anne DeLotto Baier abaier@health.usf.edu 813-974-3303 University of South Florida (USF Health) Tampa, FL (Oct. 3, 2013) -- University of South Florida researchers have suggested a new view of how stem cells may help repair the brain following trauma. In a series of preclinical experiments, they report that transplanted cells appear to build a "biobridge" that links an uninjured brain site where new neural stem cells are born with the damaged region of the brain. Their findings were recently reported online in the peer-reviewed journal PLOS ONE. "The transplanted stem cells serve as migratory cues for the brain's own neurogenic cells, guiding the exodus of these newly formed host cells from their neurogenic niche towards the injured brain tissue," said principal investigator Cesar Borlongan, PhD, professor and director of the USF Center for Aging and Brain Repair. Based in part on the data reported by the USF researchers in this preclinical study, the U.S. Food and Drug Administration recently approved a limited clinical trial to transplant SanBio Inc's SB632 cells (an adult stem cell therapy) in patients with traumatic brain injury. Stem cells are undifferentiated, or blank, cells with the … Continue reading →

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