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Scientists Create Early Liver From Human Stem Cells

Posted: Published on July 4th, 2013

Scientists used human stem cells to create precursors to human livers like those in fetuses, and the early organs functioned as livers when transplanted into mice. These buds didnt grow into regular livers and any treatment for humans is at least a decade away, according to the research published in the journal Nature. Still, the study demonstrated the first steps toward potentially creating new organs for transplants, researchers said. Demand for organ transplant outpaces the number of donors, with more than 118,000 Americans waiting for a life-saving transplant, according to the U.S. Department of Health and Human Services. An average of 18 people die each day waiting for an organ transplant. Stem cells, which can grow into any other type of cell, have long held the promise of bridging this gap. The study holds out real promise for a viable alternative approach to human organ transplants, said Matthew Smalley, a senior lecturer at Cardiff Universitys European Cancer Stem Cell Research Institute who wasnt involved in the study. Japanese scientists, mostly from Yokohama City University, planted the liver buds on the heads and abdomens of mice, according to the paper released yesterday. The heads allowed for a better view of how … Continue reading →

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Research and Markets: Stem Cells Market – Global Industry Analysis: 2012 – 2018 Report Highlights the Market Shares of …

Posted: Published on July 4th, 2013

DUBLIN--(BUSINESS WIRE)-- Research and Markets (http://www.researchandmarkets.com/research/9ccw77/stem_cells_market) has announced the addition of the "Stem Cells Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2012 - 2018" report to their offering. Stem cells are undifferentiated cells which are capable of differentiating into any type of cell that make-up the human body and thus, are capable of producing non-regenerative cells such as neural and myocardial cells. This report estimates the market for global stem cells in terms of revenue (USD billion) for the period 2012 - 2018, keeping 2011 as the base year. The global stem cells market is mainly segmented into four major sub-types namely market by products, market by technology, market by applications and market by geography. The global stem cells market by technology is segmented into four sub-types, namely cell acquisition, cell production, cryopreservation and expansion and sub-culture. Cell acquisition is further segmented into three sub-types, namely bone marrow harvest, apheresis and umbilical cord blood. Cell production is further segmented into therapeutic cloning, in vitro fertilization, isolation and cell culture. The global stem cells market by application is segmented into regenerative medicines and drug discovery and development. Regenerative medicines are further segmented into ten sub-types, namely neurological … Continue reading →

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Liver Buds Show Promise, but Growing New Organs is Still a Long Way Off

Posted: Published on July 4th, 2013

By: Rebecca Jacobson Watch this time lapse video showing how three types of stem cells organized into a three dimensional liver bud over 72 hours. Video by Takanori Takebe When stem cell biologist Takanori Takebe at Japan's Yokohama City University first saw his results in a petri dish, the feeling was hard to describe. "I think 'gobsmacked' is the closest word in English," said translator Matthew Salter from the journal Nature's Tokyo office, during a press briefing on Tuesday. Takebe and his team had mixed three cell types: adult stem cells engineered for a human liver, adult bone marrow stem cells and stem cells from a human umbilical cord. The cells self-organized into a liver bud -- a tiny, three dimensional, functioning piece of human liver, complete with a vascular system to deliver blood to the organ. When Takebe transplanted the liver bud into a mouse, it thrived, functioning like a human liver. It also helped bring the mouse back from liver failure, an important step in the team's conclusion that the liver bud was functioning, Takebe told the press. Creating fully functioning organs for transplant has been a goal of stem cell research since work on embryonic stem cells … Continue reading →

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Stem-cell therapy wipes out HIV in two patients: report

Posted: Published on July 4th, 2013

London:Two men with HIV have been off AIDS drugs for several months after receiving stem-cell transplants for cancer that appear to have cleared the virus from their bodies, researchers reported today. Both patients, who were treated in Boston and had been on long-term drug therapy to control their HIV, received stem-cell transplants after developing lymphoma, a type of blood cancer. Since the transplants, doctors have been unable to find any evidence of HIV infection, Timothy Henrich of Harvard Medical School and Brigham and Women's Hospital in Boston told an International AIDS Society conference in Kuala Lumpur. While it is too early to say for sure that the virus has disappeared from their bodies altogether, one patient has now been off antiretroviral drug treatment for 15 weeks and the other for seven weeks. Last July Henrich first reported that the two men had undetectable levels of HIV in their blood after their stem-cell treatment, but at that time they were still taking medicines to suppress HIV. Using stem-cell therapy is not seen as a viable option for widespread use, since it is extremely expensive, but the latest cases could open new avenues for fighting the disease, which infects about 34 million … Continue reading →

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Stem-cell transplants may purge HIV

Posted: Published on July 4th, 2013

Daniel Kuritzkes, a researcher working with two 'Boston patients' who may have been cured of HIV, speaks at an AIDS conference in Kuala Lumpur, Malaysia. International AIDS Society/Steve Forrest/Workers' Photos Two men with HIV may have been cured after they received stem-cell transplants to treat the blood cancer lymphoma, their doctors announced today at the International AIDS Society Conference in Kuala Lumpur. One of the men received stem-cell transplants to replace his blood-cell-producing bone marrow about three years ago, and the other five years ago. Their regimens were similar to one used on Timothy Ray Brown, the 'Berlin patient' who has been living HIV-free for six years and is the only adult to have been declared cured of HIV. Last July, doctors announced that the two men the Boston patients appeared to be living without detectable levels of HIV in their blood, but they were still taking antiretroviral medications at that time. Timothy Henrich, an HIV specialist at Brigham and Womens Hospital in Boston, Massachusetts, who helped to treat the men, says that they have now stopped their antiretroviral treatments with no ill effects. One has been off medication for 15 weeks and the other for seven. Neither has any … Continue reading →

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Italian stem-cell trial based on flawed data

Posted: Published on July 4th, 2013

The controversial stem cell therapy has garnered fervent public support, while many scientists decry it as unproven. MMaurizio D'Avanzo/Milestone/Empics Entertainment Davide Vannoni, a psychologist turned medical entrepreneur, has polarized Italian society in the past year with a bid to get his special brand of stem-cell therapy authorized. He has gained fervent public support with his claims to cure fatal illnesses and equally fervent opposition from many scientists who say that his treatment is unproven. Now those scientists want the Italian government to pull out of a 3-million (US$3.9-million) clinical trial of the therapy that it promised to support in May, after bowing to patient pressure. They allege that Vannoni's method of preparing stem cells is based on flawed data. And Nature's own investigation suggests that images used in the 2010 patent application, on which Vannoni says his method is based, are duplicated from previous, unrelated papers. The trial is a waste of money and gives false hope to desperate families, says Paolo Bianco, a stem-cell researcher at the University of Rome and one of the scientists who says that Vannonis 2010 application to the US patent office does not stand up to scrutiny. I am not surprised to learn this, … Continue reading →

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Stem-cell therapy wipes out HIV in two patients

Posted: Published on July 4th, 2013

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Bach promises big returns with ‘City for Champions’ plan

Posted: Published on July 4th, 2013

Mayor Steve Bach this week announced an ambitious plan totalling roughly $218 million to build four major attractions in Colorado Springs, without any new taxes needed. They include two downtown sites: a U.S. Olympic museum and a baseball stadium and event center (which sounds a bit like the convention center voters have refused to fund several times in the past). The other two are a University of Colorado at Colorado Springs sports medicine and performance center and an Air Force Academy visitor center outside the base's gates. Bach says the city will file its privately crafted application, dubbed "City for Champions," through a program under the Regional Tourism Act, which is designed to fund projects that will attract more out-of-state visitors. A state panel will assess the application and decide by December. Calling the projects a "catalytic spark" to ignite growth and create jobs, Bach says the money will come from state sales taxes rebated to the city ($82 million), private investment ($61.4 million), and from a variety of public sources ($74.6 million), including city borrowing. As for the latter, Bach points out that the city's nearly paid off a previous $88 million debt, issued in 1999, that funded drainage, … Continue reading →

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Vitamin C helps control gene activity in stem cells

Posted: Published on July 3rd, 2013

July 1, 2013 Vitamin C affects whether genes are switched on or off inside mouse stem cells, and may thereby play a previously unknown and fundamental role in helping to guide normal development in mice, humans and other animals, a scientific team led by UC San Francisco researchers has discovered. The researchers found that vitamin C assists enzymes that play a crucial role in releasing the brakes that keep certain genes from becoming activated in the embryo soon after fertilization, when egg and sperm fuse. The discovery might eventually lead to the use of vitamin C to improve results of in vitro fertilization, in which early embryos now are typically grown without the vitamin, and also to treat cancer, in which tumor cells abnormally engage or release these brakes on gene activation, the researchers concluded in a study published June 30, 2013 in the journal Nature. In the near term, stem-cell scientists may begin incorporating vitamin C more systematically into their procedures for growing the most healthy and useful stem cells, according to UCSF stem-cell scientist Miguel Ramalho-Santos, PhD, who led the study. In fact, the unanticipated discovery emerged from an effort to compare different formulations of the growth medium, … Continue reading →

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King's College London: The future of stem cell research – Video

Posted: Published on July 3rd, 2013

King's College London: The future of stem cell research In recent years there has been an explosion of interest in stem cells within the scientific and medical communities, as well as amongst politicians, pharmace... By: kingscollegelondon … Continue reading →

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