LEXINGTON, Mass.--(BUSINESS WIRE)-- Concert Pharmaceuticals, Inc. today announced that it has initiated a Phase 1 clinical trial with CTP-354. CTP-354 is a novel GABAA receptor subtype-selective modulator that has demonstrated no sedation at therapeutic doses in preclinical models in contrast to existing GABAA receptor non-selective agonists, such as benzodiazepines. Concert is developing CTP-354 for the potential treatment of spasticity and chronic pain. The Phase 1 single ascending dose study will evaluate the safety, tolerability and pharmacokinetics of CTP-354 in healthy volunteers. The company also intends to conduct a Positron Emission Tomography (PET) study to assess brain receptor occupancy of CTP-354 in healthy volunteers. Concert expects to report top-line results of the Phase 1 single ascending dose study by year-end. There is a significant unmet need for effective and better tolerated agents in the treatment of both spasticity and chronic pain, particularly treatments that would reduce or avoid the adverse events of sedation and ataxia that are commonly associated with existing treatments, said Roger Tung, Ph.D., President and Chief Executive Officer of Concert Pharmaceuticals. Based on CTP-354s preclinical profile, we believe it has the potential to offer patients effective treatment for these chronic conditions with an improved therapeutic profile. We look … Continue reading
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