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Healthy Living: Brain surgery for Parkinson's disease

Posted: Published on February 22nd, 2013

To view our videos, you need to enable JavaScript. Learn how. install Adobe Flash 9 or above. Install now. Then come back here and refresh the page. Parkinson's disease is a movement disorder, and over the last three decades the treatment options were limited - until now. The symptoms of Parkinson's disease include tremors. Medication is used, but long-term can make the tremors worse. Diagnosing Parkinson's can be done with a brain scan which measures the level of dopamine. Neurologist Dr. Julie Pilitsis said, "When people become symptomatic with Parkinson's, dopamine levels are about 80 percent reduced." After medications are no longer effective, some patients are candidates for brain surgery where a deep brain stimulator is implanted. "Make a small whole in the brain about the size of nickel," said Dr. Pilitsis. "We open up the covering of the brain. We use a special micro-electrode tip which is the finest thread in diameter." The micro-electrode is then fed deep through the brain to the area which, when stimulated, stops tremors. When performing surgery on the brain, you need a steady hand, and in this surgery, you need a good ear. As she passes the electrode through the neurons within the … Continue reading

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Cooling may prevent trauma-induced epilepsy

Posted: Published on February 22nd, 2013

Feb. 20, 2013 In the weeks, months and years after a severe head injury, patients often experience epileptic seizures that are difficult to control. A new study in rats suggests that gently cooling the brain after injury may prevent these seizures. "Traumatic head injury is the leading cause of acquired epilepsy in young adults, and in many cases the seizures can't be controlled with medication," says senior author Matthew Smyth, MD, associate professor of neurological surgery and of pediatrics at Washington University School of Medicine in St. Louis. "If we can confirm cooling's effectiveness in human trials, this approach may give us a safe and relatively simple way to prevent epilepsy in these patients." The researchers reported their findings in Annals of Neurology. Cooling the brain to protect it from injury is not a new concept. Cooling slows down the metabolic activity of nerve cells, and scientists think this may make it easier for brain cells to survive the stresses of an injury. Doctors currently cool infants whose brains may have had inadequate access to blood or oxygen during birth. They also cool some heart attack patients to reduce peripheral brain damage when the heart stops beating. Smyth has been … Continue reading

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Activation of cortical type 2 cannabinoid receptors ameliorates ischemic brain injury, study suggests

Posted: Published on February 22nd, 2013

Feb. 21, 2013 A new study published in the March issue of The American Journal of Pathology suggests that cortical type 2 cannabinoid (CB2) receptors might serve as potential therapeutic targets for cerebral ischemia. Researchers found that the cannabinoid trans-caryophyllene (TC) protected brain cells from the effects of ischemia in both in vivo and in vitro animal models. In rats, post-ischemic treatment with TC decreased cerebral infarct size and edema. In cell cultures composed of rat cortical neurons and glia exposed to oxygen-glucose deprivation and reoxygenation (OGD/R), TC decreased neuronal injury and mitochondrial depolarization, specifically through type 2 cannabinoid receptor (CB2R) pathways. "To our knowledge, novel data presented in this study provide evidence for the first time supporting a previously unappreciated role of cortical CB2R, especially neuronal CB2Rs, in ischemia," says lead investigator Won-Ki Kim, PhD, of the Department of Neuroscience, College of Medicine, Korea University in Seoul. "This study suggests that further investigation is warranted to establish the clinical usefulness of TC as a preventative and therapeutic agent for treatment of stroke." Results presented in the study shed light on the anatomy and mechanism of action of CB2R-mediated neuroprotection. In the in vivo study, which was performed in rats, … Continue reading

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Activation of cortical type 2 cannabinoid receptors ameliorates ischemic brain injury

Posted: Published on February 22nd, 2013

Public release date: 21-Feb-2013 [ | E-mail | Share ] Contact: David Sampson ajpmedia@elsevier.com 215-239-3171 Elsevier Health Sciences Philadelphia, PA, February 21, 2013 A new study published in the March issue of The American Journal of Pathology suggests that cortical type 2 cannabinoid (CB2) receptors might serve as potential therapeutic targets for cerebral ischemia. Researchers found that the cannabinoid trans-caryophyllene (TC) protected brain cells from the effects of ischemia in both in vivo and in vitro animal models. In rats, post-ischemic treatment with TC decreased cerebral infarct size and edema. In cell cultures composed of rat cortical neurons and glia exposed to oxygen-glucose deprivation and reoxygenation (OGD/R), TC decreased neuronal injury and mitochondrial depolarization, specifically through type 2 cannabinoid receptor (CB2R) pathways. "To our knowledge, novel data presented in this study provide evidence for the first time supporting a previously unappreciated role of cortical CB2R, especially neuronal CB2Rs, in ischemia," says lead investigator Won-Ki Kim, PhD, of the Department of Neuroscience, College of Medicine, Korea University in Seoul. "This study suggests that further investigation is warranted to establish the clinical usefulness of TC as a preventative and therapeutic agent for treatment of stroke." Results presented in the study shed light … Continue reading

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Brain Injury: My Road To Recovery – Regaining Independence

Posted: Published on February 22nd, 2013

BOSTON (CBS) Left, right, stop or slow down. After more than 30 years of driving, last October I found myself once again demonstrating to the RMV that I know my hand signals. I had suffered a traumatic brain injury in a bicycle fall three months earlier, and a medical competency road test was deemed necessary before I could get behind the wheel again. Ironically, my 16-year-old son Luke had received his junior operators license the week before, so HE gave ME pointers! I had to ask him, How bad was I? He smiled and said, You were pretty bad. Im not gonna lie. You had a lot of things wrong. You didnt know how to straighten out the wheel without letting it slide through your hands. You couldnt really park on a hill, and did not head check at all. You probably wouldnt have lasted 20 seconds in the road test. They would have failed you before you started the car. Listen: Mary Blake: My Road To Recovery Part 7 Registrar Rachel Kaprielian says medical competency tests arent that unusual. On average, roughly twenty of them are administered around the state each day. The manual Mary Blake used before her … Continue reading

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UPDATE 2-Elan to return $1 bln to shareholders from MS drug sale

Posted: Published on February 22nd, 2013

* Elan (Other OTC: ELNCF - news) to buy back $1 bln of shares after Tysabri sale * Deal is "unique opportunity" to reward shareholders * Firm still working on acquisitions with rest of proceeds * Shares climb over 4 percent By Stephen Mangan DUBLIN, Feb 22 (Reuters) - Irish drugmaker Elan will return $1 billion to shareholders, giving them an immediate boost from the sale of its stake in multiple sclerosis (MS) treatment Tysabri to partner Biogen Idec (NasdaqGS: BIIB - news) . Elan shares climbed over 4 percent following the announcement on Friday, which also reiterated the company's intention to make acquisitions with the rest of the $3.25 billion raised from the deal. Tysabri was by far Elan's most important product, responsible for almost all its revenue and its sale creates uncertainty over the future shape of the company. "Close to 40 percent of Elan's current market cap could be invested in as yet unknown assets ... we are unlikely to gain the visibility needed to become constructive on the shares until transactions are concluded," said Deutsche Bank (Xetra: 514000 - news) analyst Richard Parkes. Elan is already pursuing potential deals for the next 12-18 months, Chief Executive … Continue reading

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Elan plans $1 billion buyback and acquisitions

Posted: Published on February 22nd, 2013

DUBLIN (Reuters) - Irish drugmaker Elan (Other OTC: ELNCF - news) will return $1 billion (654 million pounds) to shareholders and seek acquisitions with the proceeds of selling its stake in blockbuster multiple sclerosis (MS) treatment Tysabri to partner Biogen Idec (NasdaqGS: BIIB - news) . The sale of Tysabri, which was by far Elan's most important product and responsible for almost all its revenue, leaves the company's future shape unclear, but the deal now offers it flexibility to buy new assets. The company said on Friday it would use almost a third of the $3.25 billion from the deal to buy back shares. "By unlocking a portion of the Tysabri asset value ... we have a unique opportunity to reward shareholders, diversify our business and create a highly distinctive business platform upon which to advance to the benefit of shareholders and patients around the world," Elan Chief Executive CEO Kelly Martin said. Elan is already pursuing potential deals for the next 12-18 months, Martin told Reuters in an interview earlier this month, which he said may not necessarily be restricted to the company's past. The Irish drugmaker has co-marketed Tysabri with the larger U.S. company for 12 years and … Continue reading

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The MS Center of Atlanta Partners with Georgia Partnership for TeleHealth

Posted: Published on February 22nd, 2013

The MS Center of Atlanta, along with the NMSS (National Multiple Sclerosis Society), are dedicated to remove all barriers to patient care. The Center is proud to team up with GPT (Georgia Partnership of Telehealth) and Dr. Brian Griner to set up the first dedicated telehealth center for MS in Valdosta, Georgia. (PRWEB) February 22, 2013 The MS Center of Atlanta, along with the NMSS (National Multiple Sclerosis Society), are dedicated to remove all barriers to patient care. The Center is proud to team up with GPT (Georgia Partnership of Telehealth) and Dr. Brian Griner to set up the first dedicated telehealth center for MS in Valdosta, Georgia. Dr. Griner is a Primary Care Physician and Dr. Jeffrey English along with the Centers other staff neurologist are on the MS Center side of this partnership. Patients will be able to see their MS specialist immediately from a primary care facility without traveling 4.5 hours (each way). The Center is to have sites across Georgia and hope the future will allow such care directly from every primary care physician's office. Separately Dr. English is developing similar relationships for concussion management through SCI-Atlanta (Sports Concussion Institute at Atlanta). Athletes with suspected concussion … Continue reading

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Elan to return $1 billion to shareholders from multiple sclerosis drug sale

Posted: Published on February 22nd, 2013

DUBLIN (Reuters) - Irish drugmaker Elan will return $1 billion to shareholders, giving them an immediate boost from the sale of its stake in multiple sclerosis (MS) treatment Tysabri to partner Biogen Idec. Elan shares climbed over 4 percent following the announcement on Friday, which also reiterated the company's intention to make acquisitions with the rest of the $3.25 billion raised from the deal. Tysabri was by far Elan's most important product, responsible for almost all its revenue and its sale creates uncertainty over the future shape of the company. "Close to 40 percent of Elan's current market cap could be invested in as yet unknown assets ... we are unlikely to gain the visibility needed to become constructive on the shares until transactions are concluded," said Deutsche Bank analyst Richard Parkes. Elan is already pursuing potential deals for the next 12-18 months, Chief Executive Kelly Martin told Reuters in an interview this month, which he said may not necessarily be restricted to the firm's past areas of activity. "By unlocking a portion of the Tysabri asset value ... we have a unique opportunity to reward shareholders, diversify our business and create a highly distinctive business platform upon which to … Continue reading

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Cancer drug a possible treatment for multiple sclerosis, rat study suggests

Posted: Published on February 22nd, 2013

Feb. 21, 2013 A drug that is currently used for cancer can relieve and slow down the progression of the autoimmune disease multiple sclerosis (MS) in rats, according to a new study published in PLOS ONE. The discovery, which was made by researchers at Karolinska Institutet in Sweden, might one day lead to better forms of treatment for patients with MS. Multiple sclerosis is a disease in which the immune system attacks the spinal cord and brain, damaging nerve tissues to cause visual impairment, paralysis and other neurological disabilities. There are approximately 17,000 MS victims in Sweden, most of who develop the disease between the age of 20 and 40. The disease is currently incurable, and the treatments that are able to ameliorate the symptoms can have severe side effects. "There is a particularly urgent need to find new, efficacious drugs with minimal adverse effects for patients with MS in the relapsing phase of the disease," says Assistant Professor Ingrid Nilsson at Karolinska Institute's Department of Medical Chemistry and Biophysics. The disease is caused when white blood cells attack the central nervous system. The CNS is normally protected by the blood-brain barrier, which governs what passes through the vascular walls. … Continue reading

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