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Protein paves the way for correct stem cell differentiation

Posted: Published on February 8th, 2013

Feb. 7, 2013 A single embryonic stem cell can develop into more than 200 specialized cell types that make up our body. This maturation process is called differentiation and is tightly regulated through strict control of gene activity. If the regulation is lost, specialized cells cannot develop correctly during development. In adulthood, the specialized cells may forget their identity and develop into cancer cells. Research from BRIC, University of Copenhagen, has identified a crucial role of the molecule Fbxl10 in differentiation of embryonic stem cells and suggests the molecule as a new potential target for cancer therapy. "Our new results show that this molecule is required for the function of one of the most important molecular switches that constantly regulates the activity of our genes. If Fbxl10 is not present in embryonic stem cells, the cells cannot differentiate properly and this can lead to developmental defects," says Professor Kristian Helin, who heads the research group behind the new findings. Fbxl10 recruits and activates genetic switches The Polycomb protein complexes PRC1 and PRC2 are some of the most important genetics switches, which control the fate of individual cells through negative regulation of gene activity. The mechanism by which PRCs are recruited … Continue reading

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PRESS RELEASE: MagForce to implement capital increase of up to EUR33.5 million

Posted: Published on February 8th, 2013

MagForce AG / MagForce to implement capital increase of up to EUR33.5 million . Processed and transmitted by Thomson Reuters ONE. The issuer is solely responsible for the content of this announcement. NOT FOR DISTRIBUTION IN THE USA, CANADA, JAPAN, OR AUSTRALIA * Capital increase against cash and noncash contributions including preemptive rights * Funds to go towards post-marketing study and loan repayment * BaFin approves securities prospectus Berlin, Germany, February 08, 2013 - MagForce AG (Frankfurt, XETRA: MF6), a leading medical technology company in the field of nanomedicine in oncology, intends to implement a capital increase against cash and noncash contributions including preemptive rights in the total amount of around EUR33.5 million. To achieve this, up to 18,606,553 new no-par value bearer shares will be issued. The capitalization measure was resolved at the Company's extraordinary general meeting on January 25, 2013. Bankhaus Neelmeyer AG, Bremen, will offer the new shares to the Company's shareholders for sub-scription at a ratio of 2:7. The subscription price for the new shares will be EUR1.80 per share. The two-week shareholders' subscription period will run from February 14 to February 28, 2013. Clearstream Banking AG, Frankfurt am Main, will settle the rights for the … Continue reading

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MagForce to implement capital increase of up to €33.5 million

Posted: Published on February 8th, 2013

NOT FOR DISTRIBUTION IN THE USA, CANADA, JAPAN, OR AUSTRALIA Berlin, Germany, February 08, 2013 - MagForce AG (Frankfurt, XETRA: MF6), a leading medical technology company in the field of nanomedicine in oncology, intends to implement a capital increase against cash and noncash contributions including preemptive rights in the total amount of around 33.5 million. To achieve this, up to 18,606,553 new no-par value bearer shares will be issued. The capitalization measure was resolved at the Company`s extraordinary general meeting on January 25, 2013. Bankhaus Neelmeyer AG, Bremen, will offer the new shares to the Company`s shareholders for sub-scription at a ratio of 2:7. The subscription price for the new shares will be 1.80 per share. The two-week shareholders` subscription period will run from February 14 to February 28, 2013. Clearstream Banking AG, Frankfurt am Main, will settle the rights for the new shares. The rights will not be traded on the stock exchange. Further details are provided in the securities prospectus, which the company filed with the commercial register today. In line with legal requirements, Bundesanstalt fr Finanzdienstleistungsaufsicht (BaFin - the German Financial Supervisory Authority) examined and approved the prospectus. It is expected to be published in the Bundesanzeiger … Continue reading

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Vigrx Plus Honest Review-Doctor Steven Lamm Reviews Vigrx Plus – Product For Penis Enlargement – Video

Posted: Published on February 8th, 2013

Vigrx Plus Honest Review-Doctor Steven Lamm Reviews Vigrx Plus - Product For Penis Enlargement malesexualstaminapills.com - more information about Vigrx Plus as well as the other enhancement products such as Prosolution, Extenze, Semenax. By: vigrxplusreviews1 … Continue reading

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Preventing Premature Ejaculation – Video

Posted: Published on February 8th, 2013

Preventing Premature Ejaculation Business Channel: http://www.youtube.com Visit my other channel IF you don't get uptight about politics: http://www.youtube.com Ask The Machine--email marc@tigerfitness.com Song Credit in outro: Cradle Theory at http://www.youtube.com TigerFitness.com Makes The INC. 500!! http://www.tigerfitness.com MARC'S FREE BOOK FOR ULTIMATE FAT LOSS! http://www.fatlossfactorbook.com The Whey Protein you need: http://www.MTSNutrition.com Ethical Supplements you need http://www.ethitechnutrition.com The MUST READ Webzine http://www.MachineMuscle.com The Website to BUY SUPPLEMENTS FROM http://www.TigerFitness.com By: TheTigerFitness … Continue reading

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Indiana school system may limit student prescriptions

Posted: Published on February 8th, 2013

Aftershocks hamper relief in tsunami-hit Solomons Aftershocks hamper relief in tsunami-hit Solomons A tsunami alert has been issued after a strong earthquake in the South Pacific.More >> Strong aftershocks rattled the Solomon Islands on Friday, hampering relief efforts to tsunami-ravaged villages and forcing the South Pacific nation's prime minister to forgo a visit to the stricken area, where nine...More >> Polish transsexual lawmaker loses shot at top post Polish transsexual lawmaker loses shot at top post The before and after photos of Anna Grodzka show how much she - and her country - have transformed.More >> The before and after photos of Anna Grodzka show how much she - and her country - have transformed.More >> Owensboro prepares to take the 'Plunge' Owensboro prepares to take the 'Plunge' Updated: Friday, February 8 2013 7:12 AM EST2013-02-08 12:12:48 GMT Updated: Friday, February 8 2013 7:08 AM EST2013-02-08 12:08:52 GMT A central Indiana school district is considering changing how it handles student medications, including limiting the amount allowed per student and requiring parents to bring medications in themselves instead of sending them with students. The Greenfield-Central School Board will consider the proposed policy at its meeting Monday. The Daily Reporter says the … Continue reading

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Side Effects: One Pill Makes You Murder

Posted: Published on February 8th, 2013

TV commercials for virility or antidepressant medications often devote most of their two-minute spiels to describing the awful incidental maladies that may befall the pill-taker. By the end of the Doomsday small print, youre likely to think: That which makes me stronger may also kill me. A similar warning should attend any review of Side Effects.Revealing the usual amount of plot would be unfair to viewers with a right to be as surprised as most critics have been. Directed by Steven Soderbergh and written by Scott Z. Burns, who previously collaborated on the twisty thrillers Contagion and The Informant!,the new movieis like a secret too cool to keep but too treacherous to share. Side Effectsvirtually demands a three-word review: Just see it. Soderbergh has said that this is the last movie he will direct for a while. (Hes got a TV film, the Liberace biopic Behind the Candelabra, set for airing on HBO later this year.) The industrys most prodigious auteur may be entitled to a rest. Now in his 25th year since his 1989 debut withsex, lies and videotape, Soderbergh has directed 25 features, including eight in the last five years. Hes also an active producer, shepherding such films … Continue reading

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In 'Side Effects,' Soderbergh Explores Money Again

Posted: Published on February 8th, 2013

Steven Soderbergh has money issues. From the bank robbers of Out of Sight to the drug dealers of Traffic to the sex workers of The Girlfriend Experience and Magic Mike, the costs vs. benefits of American success has always been at the core of the 50-year-old directors work. He scored his two biggest hits, in 2000 and 2001, by reinvigorating classic Hollywood tropes about money: Erin Brockovich, in the strident anticorporate vein of Silkwood, starred Julia Roberts as an environmental crusader in a push-up bra and netted $250 million. Oceans Eleven did even better, launching a $1.1billion trilogy. The candy-colored remake of a 1960 Sinatra film rediscovered a lost formula: the heist flick with a cavalcade of stars. There hasnt been a film as successful in either genre since. Soderberghs newest, Side Effects, opening on Feb.7, stars Channing Tatum as Martin, a hotshot Wall Street trader whos just done time for insider trading. Rooney Mara plays his wife, Emily, a depressive whose condition escalates after his return. As Martin scrambles to launch a scheme with a financial whiz he met in prison, Emily is prescribed a mood-inhibiting antidepressant that seems to produce terrible Side Effectscrying jags, sleepwalking, suicidal thoughts, and … Continue reading

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'Side Effects' Serves As Thrilling Capper To Adventurous Career For Director Soderbergh

Posted: Published on February 8th, 2013

Posted: Feb. 8, 2013 | 2:12 a.m. Possible side effects of watching "Side Effects" include increased brain activity, confusion, occasional irritability and warm, fuzzy feelings about Jude Law. "Side Effects" is not intended for use by children or people suffering from short attention spans. If you experience an erection lasting longer than four hours, keep it to yourself, weirdo. Interestingly, for a movie based on the hidden dangers of pharmaceuticals, it turns out the less you know about "Side Effects" - director Steven Soderbergh's big-screen swan song - the better. Emily Taylor (a haunted-looking Rooney Mara) had every luxury money could buy - until her husband, Martin (Channing Tatum), went to prison for insider trading and her perfect world was pulled out from under her. After four years of hardship, his release should have put a little color in her cheeks. Instead, she slips back into the sort of overwhelming hopelessness that first accompanied his arrest. Following a botched attempt to harm herself, Emily comes under the care of Jonathan Banks (Law), a sympathetic psychiatrist who begins treating her with antidepressants that make her nauseous and kill her sex drive. But when a friend recommends the new drug Ablixa, which … Continue reading

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Jude Law in ‘Side Effects’; Shakespeare in Jail: Movies

Posted: Published on February 8th, 2013

The quietly bloody opening of Steven Soderberghs psychiatric-meds melodrama Side Effects leaves a horror-movie chill. Then the picture unfolds so upsettingly that the last thing I expected was to be laughing my head off by the end. The title refers specifically to the malign side effects of prescription antidepressants. A psychiatrist (Jude Law) takes on a suicidal patient (Rooney Mara), whose husband (Channing Tatum) has just finished a four-year sentence for insider trading. The shrink puts her on a fictional pill called Ablixa. The critique of Big Pharma is implicit throughout: Hes also being paid $50,000 to enlist guinea pigs for yet another new drug. We see one patient jump at the chance -- never mind the risks -- as soon as she finds out its free. The terrific cast includes Vinessa Shaw as Laws wife, Ann Dowd as Tatums mother and Catherine Zeta-Jones with her hair yanked back in a bun and a bearing hard enough to break teeth. Thomas Newmans initially delicate score draws you in without directing your feelings at every minute. The demonically clever script, by Scott Z. Burns, dances dangerously close to the edge of oh-come-on -- and in retrospect there are a couple of … Continue reading

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