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Stem Cells From Patients or Donors May Help Treat Diseased Hearts

Posted: Published on November 7th, 2012

Study Highlights: LOS ANGELES, Nov. 5, 2012 (GLOBE NEWSWIRE) -- Stem cells taken from patients or donors can treat people with enlarged hearts safely and with similar effectiveness, according to late-breaking clinical trial results presented at the American Heart Association's Scientific Sessions 2012. The Comparison of Allogeneic vs. Autologous Bone Marrow Derived Mesenchymal Stem Cells Delivered by Transendocardial Injection in Patients with Ischemic Cardiomyopathy trial (POISEIDON) is also published in the Journal of the American Medical Association. "This cell therapy clearly had some clinical benefits and the mesenchymal stem cells from donors were just as safe as those from the recipient," said Joshua Hare, M.D., the lead study author. "Even in patients who had heart attacks several decades before treatment, both donor and recipient stem cells reduced the amount of scarring substantially, by one-third." The mesenchymal stem cells (MSCs) -- unique because the body's protective antibodies don't attack them -- are found in adults' bone marrow. Previous studies indicated that MSCs might improve heart muscle function in patients with heart scarring from a prior heart attack. Heart muscle weakening from such scars (ischemic cardiomyopathy) is the most common cause of debilitating and deadly congestive heart failure. The 13-month trial is … Continue reading

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Stem cells from strangers may heal scarred hearts

Posted: Published on November 7th, 2012

Scientists have successfully transplanted stem cells from donors into patients who suffered heart attacks and reduced their heart damage. The new research suggests stem cells donated by strangers proved as safe and effective as patients' own cells for helping restore heart tissue. The study, published in the Nov. 5 issue of the Journal of the American Medical Association, involved only 30 patients in Miami and Baltimore, but it proves the concept that anyone's cells can be used to treat such cases. Doctors are excited because this suggests that stem cells could be banked for off-the-shelf use after heart attacks, just as blood is kept on hand now. Results were also discussed Monday at an American Heart Association conference in Los Angeles. The study used a specific type of stem cells from bone marrow, called mesenchymal stem cells, that researchers believed would not be rejected by recipients' immune systems. Unlike other cells, these lack a key feature on their surface that makes the body's protective antibodies see them as foreign tissue and attack them, explained the study's leader, Dr. Joshua Hare, director of the Interdisciplinary Stem Cell Institute at the University of Miami. Study participants had suffered heart attacks years earlier, … Continue reading

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Stem Cells From Donor May Help Heal Heart

Posted: Published on November 7th, 2012

By E.J. Mundell HealthDay Reporter TUESDAY, Nov. 6 (HealthDay News) -- A small study suggests that stem cells can help repair the damage of a heart attack, and it doesn't matter if the cells originate with the patient or a stranger. The study, which involved just 30 patients, is the first involving a certain type of cells, called mesenchymal stem cells, that compares outcomes depending on whether the cells came from the patient or a donor. Across most measures -- including reductions in cardiac scar tissue, patient quality of life and safety -- people got the same benefit regardless of where the stem cells came from, researchers reported Monday at the annual meeting of the American Heart Association in Los Angeles. The study is also being published online Nov. 6 in the Journal of the American Medical Association. "We believe the basic message of the study is that this procedure is safe and that future, larger studies are warranted," lead study author Dr. Joshua Hare, director of the Interdisciplinary Stem Cell Institute at the University of Miami Miller School of Medicine, said at a news briefing. Millions of people around the world suffer from heart failure, often caused by a … Continue reading

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Donated stem cells may work best for heart patients

Posted: Published on November 7th, 2012

Stem cells culled from the bone marrow of healthy donors work as well or even better as cells harvested from patients themselves as a treatment for damaged hearts and are more convenient to use, according to new research. The 13-month trial was the first to compare the safety and effectiveness of so-called mesenchymal, or bone marrow-derived, stem cells taken from patients themselves versus those provided by donors. Such adult stem cells that renew themselves and mature into specific cell types have been used for 40 years in bone marrow transplants. Scientists are now exploring their use as treatments for ailments such as heart disease and inflammatory conditions, some of the biggest markets in medicine. The rationale behind using patients' own stem cells to treat disease is that they do not trigger an attack by the body's immune system. Mesenchymal stem cells, however, are also not recognized as foreign tissue. Researchers from the University of Miami Miller School of Medicine, funded by the National Institutes of Health, found that previously prepared cells from a healthy donor were comparatively safe and may offer the most convenience since it takes up to eight weeks to grow the amount of stem cells needed for … Continue reading

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Advocates, Patients Rally To Support Sarepta Early Drug Approval Push

Posted: Published on November 7th, 2012

BOSTON (TheStreet) -- Duchenne muscular dystrophy (DMD) advocacy groups are mobilizing to support efforts by Sarepta Therapeutics (SRPT) to seek accelerated approval for its experimental drug eteplirsen. Some of these groups, accompanied by parents of DMD patients, have already met with U.S. Food and Drug Administration officials to make sure regulators understand the urgent need for new therapies. More meetings with U.S. regulators are planned. Sarepta will meet with the FDA, likely early next year, to present results from the eteplirsen phase IIb study and request permission to file for accelerated approval. The company is holding a conference call Wednesday in conjunction with third-quarter financial results. See if (SRPT) is in our portfolio "We are absolutely going to do everything we can to get eteplirsen approved," said Sharon Hesterlee, senior director of research at Parent Project Muscular Dystrophy (PPMD), the largest DMD non-profit in the U.S. Originally posted here: Advocates, Patients Rally To Support Sarepta Early Drug Approval Push … Continue reading

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Autism treatment in homeopathy – Tv9 – Video

Posted: Published on November 7th, 2012

Autism treatment in homeopathy - Tv9 Autism treatment in homeopathy For more content go to http://www.freetv9.com Follow us on facebook at http Follow us on twitter at twitter.comFrom:tv9teluguViews:0 0ratingsTime:24:49More inNews Politics Read more here: Autism treatment in homeopathy - Tv9 - Video … Continue reading

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Early intervention works in autism

Posted: Published on November 7th, 2012

Washington, November 7 (ANI): Children with autism spectrum disorders (ASD), who are given early treatment, made significant improvements in behaviour, communication, and most strikingly, brain function, a new study by Yale School of Medicine researchers has found. The results suggest that brain systems supporting social perception respond well to an early intervention behavioural program called pivotal response treatment. This treatment includes parent training, and employs play in its methods. ASDs are complex neurobiological disorders that inhibit a person's ability to communicate and develop social relationships, and are often accompanied by behavioural challenges. Until recently, autism diagnosis typically did not occur until a child was about three to five-years-old, and treatment programs were geared for this older age group. Yale Child Study Center researchers Fred Volkmar, M.D., Kevin A. Pelphrey, and their colleagues are diagnosing children as young as age one. Pivotal response treatment, developed at the University of California-Santa Barbara, combines developmental aspects of learning and development, and is easy to implement in children younger than age two. In the current study, the team used functional magnetic resonance imageing - for the first time - to measure changes in brain activity after two five-year-olds with ASD received pivotal response treatment. … Continue reading

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Early treatment sparks striking brain changes in autism

Posted: Published on November 7th, 2012

ScienceDaily (Nov. 6, 2012) When given early treatment, children with autism spectrum disorders (ASD) made significant improvements in behavior, communication, and most strikingly, brain function, Yale School of Medicine researchers report in a new study. The study was published in the current issue of the Journal of Autism and Developmental Disorders by Yale Child Study Center researchers Dr. Fred Volkmar, Kevin A. Pelphrey, and their colleagues. The results suggest that brain systems supporting social perception respond well to an early intervention behavioral program called pivotal response treatment. This treatment includes parent training, and employs play in its methods. ASDs are complex neurobiological disorders that inhibit a person's ability to communicate and develop social relationships, and are often accompanied by behavioral challenges. Until recently, autism diagnosis typically did not occur until a child was about three- to five-years-old, and treatment programs were geared for this older age group. Today, Volkmar and his team are diagnosing children as young as age one. Pivotal response treatment, developed at the University of California-Santa Barbara, combines developmental aspects of learning and development, and is easy to implement in children younger than age two. In the current study, the team used functional magnetic resonance imaging -- … Continue reading

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MedRecallNews.com Consumer Advocates, Philadelphia, PA

Posted: Published on November 7th, 2012

Philadelphia, PA (PRWEB) November 07, 2012 Beware of the dialysis danger zone! A popular dialysis treatment has been found to be responsible for an increased risk of sudden death from stroke and cardiac arrest. Med Recall News, the leading free Internet source on defective prescription medication and medical devices, has issued an official consumer alert today and posted free information about the dialysis treatment risk on its website. The United States Food and Drug Administration actually issued the most serious class one recall alert for a very common dialysis treatment, said Jesse Levine with MedRecall News. It caused so many health problems that they actually required the treatment to be pulled from the market. The common dialysis medication GranuFlo was found to increase bicarbonate levels in the blood, causing a condition called alkalosis. According to the FDA, alkalosis is responsible for the advanced risk of cardiac problems for users of the popular dialysis drug. In 2011, Fresenius Medical Care (FMC) issued an internal notice to its company-owned clinics, warning of the risks and side effects of GranuFlo. However; they failed to issue warnings to thousands of physicians and clinics not owned by FMC who continued to use their product. Dialysis … Continue reading

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Home blood pressure monitoring may not benefit patients with stroke and hypertension

Posted: Published on November 7th, 2012

ScienceDaily (Nov. 5, 2012) Home blood pressure monitoring may help patients with hypertension and stroke but did not improve blood pressure control for patients who had normal blood pressure at the start or those with disabilities, according to a randomized controlled trial published in CMAJ (Canadian Medical Association Journal). "Overall, home monitoring did not improve blood pressure control in an unselected group of patients with hypertension and a history of stroke. However, it was associated with more changes in antihypertensive treatment during the trial, which suggested more active management in the intervention group," writes Sally Kerry, Centre for Primary Care and Public Health, Queen Mary, University of London, UK, with coauthors. Good blood pressure control can significantly reduce the risk of recurrent stroke in the estimated 15 million people who have strokes each year worldwide. Studies show that home monitoring is associated with lower blood pressure. The study involved 381 participants aged 30 (mean 72) years from three stroke units in London, UK, who were assigned to home monitoring or to a control group of usual care. Participants in the monitoring group were given a blood pressure monitor, brief training and telephone support from a nurse. The trial, including follow … Continue reading

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