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Pluristem begins Phase II artery-disease clinical trial

Posted: Published on August 24th, 2012

Stem cell company Pluristem Therapeutics Ltd. (Nasdaq:PSTI; DAX: PJT: PLTR) today announced it is about to begin Phase II clinical trials in the US to evaluate the safety and efficacy of its PLacental Expanded (PLX) cells in the treatment of Intermittent Claudication (IC), a type of peripheral artery disease (PAD). The US Food and Drug Administration (FDA) granted clearance to start the Phase II clinical trial in April, and Pluristem, which develops placenta-based cell therapies, will commence the trials in the first week of September. Pluristem has already received Institutional Review Board (IRB) approval for the trial protocol for five out of the eleven US clinical site locations via its relationship with Western IRB, which has approved Pluristem's protocol. Site initiation will begin on September 5th at Duke University Medical Center with other sites becoming active in the following weeks following. Pluristem also plans to initiate trials in Europe and Israel in parallel to the eleven US sites. The study's lead principal investigator at Duke Dr. Manesh Patel said, "We are pleased to participate in the clinical trial process of this novel technology. Duke University Medical Center participated as a clinical site in Pluristem's Phase I/II trial using PLX-PAD cells … Continue reading →

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Italian court OKs stem cell cure for toddler

Posted: Published on August 24th, 2012

(AP) MILAN - Doctors are preparing an emergency one-off stem cell treatment for 2-year-old Venetian girl suffering a severe muscular disease after a judge revoked an order blocking the cure. Brescia hospital officials said Thursday the treatment for Celeste Carrer would begin within days. Carrer suffers from spinal muscular atrophy, which has a life expectancy of about two years. Her family reported marked improvement after beginning the experimental treatment this winter. But the stem cell lab was shut down in May after Italy's drug agency determined it was not hygienic and had violated procedures. A judge in Venice has allowed one treatment pending a final ruling, expected next week, on the family's appeal. Besides reactivating the lab, doctors must determine if the stem cells from the girl's mother remain viable. Stem cells in tumors may fuel cancer regrowth, new studies suggest Timothy Ray Brown, man thought to be first "cured" of AIDS, says he's still cured 10-year-old girl gets new vein made from her own stem cells in medical first Excerpt from: Italian court OKs stem cell cure for toddler … Continue reading →

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Restaurant's T-shirt design contest to raise money for autism research

Posted: Published on August 23rd, 2012

Its almost time to design a T-shirt for autism research and dine at a Culvers restaurant in the East Valley. From 4 p.m. to 8 p.m. Thursday, Aug. 23, the Culvers restaurant at 3155 W. Ray Road in Chandler, is hosting its inaugural Eat, Dine and T-shirt Design Contest for the 8th Annual ZooWalk for Autism Research. The restaurant will be donate 10 percent of its proceeds from The ZooWalk for Autism and Aspergers Research, which partners with Arizona State Universitys Autism and Aspergers Research Program, is scheduled for Oct. 6 at the Phoenix Zoo in Papago Park. But Culvers is encouraging artists both adults and children to come into the eatery now with ideas for their artwork. Two categories of the artwork (child and adult), which usually is animal-themed, will be chosen to be placed on the back of a T-shirt for the walk, in which about 5,000 people participate. This years ZooWalk, which raises nearly $300,000 annually from private and corporate donations, is dedicated to a one-year multi-treatment study at ASU for children and adults with autism. The study will involve a combination of special vitamins, minerals, essential fatty acids, carnitine (to boost energy metabolism) and special diet … Continue reading →

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Controversial auditory therapy may be beneficial for kids with autism

Posted: Published on August 23rd, 2012

Any parent or teacher of a child with autism will tell you the heartbreak they feel when they call a child's name and he or she doesn't respond. This most basic social interaction is often a challenge for children on the autism spectrum and in turn, more complex social exchanges seem insurmountable. "I'm less worried about his academic skills. I want him to be able to be in a room with people and like being there," said one parent of a child with autism that I know. "I want people to like having him there." Related: Doctors announce FDA-approved trial to cure autism with cord blood This desire for engagement is common for families raising children with autism, whose social and attention deficits often account for a significant amount of their challenges. Parents have been seeking therapies to increase attention and interaction for years. One treatment continues to remain a part of the conversation today. Auditory integration training, or AIT, was developed in the 1950s by Dr. Guy Berard, an otolaryngologist, in Annecy, France. Originally designed to improve hearing loss or other hearing impairments, Berard considered hearing imbalances and poor auditory processing skills a contributing factor to academic, social, and … Continue reading →

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Therapeutic avenues for Parkinson's investigated

Posted: Published on August 23rd, 2012

ScienceDaily (Aug. 23, 2012) Scientists at the University of Houston (UH) have discovered what may possibly be a key ingredient in the fight against Parkinson's disease. Affecting more than 500,000 people in the U.S., Parkinson's disease is a degenerative disorder of the central nervous system marked by a loss of certain nerve cells in the brain, causing a lack of dopamine. These dopamine-producing neurons are in a section of the midbrain that regulates body control and movement. In a study recently published in the Proceedings of the National Academy of Sciences (PNAS), researchers from the UH Center for Nuclear Receptors and Cell Signaling (CNRCS) demonstrated that the nuclear receptor liver X receptor beta (LXRbeta) may play a role in the prevention and treatment of this progressive neurodegenerative disease. "LXRbeta performs an important function in the development of the central nervous system, and our work indicates that the presence of LXRbeta promotes the survival of dopaminergic neurons, which are the main source of dopamine in the central nervous system," said CNRCS director and professor Jan-ke Gustafsson, whose lab discovered LXRbeta in 1995. "The receptor continues to show promise as a potential therapeutic target for this disease, as well as other neurological … Continue reading →

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Looking At Dipraglurant For Parkinson's Disease

Posted: Published on August 23rd, 2012

By Jason Napodano, CFA Parkinson's Disease Parkinsons disease (PD) is a neurodegenerative brain disorder that results from the death of dopamine-generating cells in the substantia nigra region of the midbrain. PD is also characterized by the accumulation of a protein called alpha-synuclein into inclusions called Lewy bodies in neurons. The cause of PD is generally idiopathic, although some atypical cases have a genetic origin. The disease is named after the English doctor James Parkinson, who published the first detailed description in An Essay on the Shaking Palsy in 1817. PD patients often exhibit marked reduction in motor control and an increase in parkinsonism (tremors, hypokinesia, rigidity, bradykinesia, and postural instability). However, as the disease progresses, patients often exhibit non-motor symptoms that include autonomic dysfunction, neuropsychiatric problems (mood, cognition, behavior or thought alterations, psychosis), and sensory and sleep difficulties. Parkinsons disease psychosis (PDP) is common in nearly 50% of PD patients a decade after initial diagnosis. Anxiety and depression are common co-morbidities. Initial signs of PD include shaking, loss of smell, difficulty writing, trouble sleeping, constipation, and poor posture. Diagnosis of a typical case is mainly based on symptoms, with tests such as neuroimaging used for confirmation. There is no cure … Continue reading →

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Florida Orders Brain-Injury Center to Move Some Patients

Posted: Published on August 23rd, 2012

By David Armstrong - 2012-08-23T21:10:29Z You need to enable Javascript to play media on Bloomberg.com Play FINR Staff Member Allegedly Pushes Patient Down A Florida brain-injury center facing allegations of abuse has been ordered to move dozens of its patients to other facilities, according to a state report released today. The Florida Institute for Neurologic Rehabilitation, one of the largest facilities of its kind in the country, is treating patients without brain injuries -- a breach of its license, say Florida regulators. During a surprise inspection earlier this month, state officials say they found that 50 of 98 patients whose records were reviewed did not meet the licensing criteria for treatment at the centers main facility near Wauchula, about 50 miles Southeast of Tampa. The state said the institute, commonly called FINR, must submit a plan to relocate those patients to a facility that is appropriate to meet their needs. The Florida Agency for Health Care Administration also found that FINR was keeping patients too long, another violation of its transitional living facility license. It ordered the center to develop a new protocol for discharging patients. Wayne J. Miller, an attorney representing FINR, didnt immediately return messages seeking comment. See … Continue reading →

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Nanoparticles reboot blood flow in brain

Posted: Published on August 23rd, 2012

A nanoparticle developed at Rice University and tested in collaboration with Baylor College of Medicine (BCM) may bring great benefits to the emergency treatment of brain-injury victims, even those with mild injuries. Combined polyethylene glycol-hydrophilic carbon clusters (PEG-HCC), already being tested to enhance cancer treatment, are also adept antioxidants. In animal studies, injections of PEG-HCC during initial treatment after an injury helped restore balance to the brain's vascular system. The results were reported this month in the American Chemical Society journal ACS Nano. A PEG-HCC infusion that quickly stabilizes blood flow in the brain would be a significant advance for emergency care workers and battlefield medics, said Rice chemist and co-author James Tour. "This might be a first line of defense against reactive oxygen species (ROS) that are always overstimulated during a medical trauma, whether that be to an accident victim or an injured soldier," said Tour, Rice's T.T. and W.F. Chao Chair in Chemistry as well as a professor of mechanical engineering and materials science and of computer science. "They're certainly exacerbated when there's trauma with massive blood loss." In a traumatic brain injury, cells release an excessive amount of an ROS known as superoxide (SO) into the blood. … Continue reading →

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/R E P E A T — A&W Rendez-vous to end MS: On Thursday, August 23, join Patricia Paquin and the Multiple Sclerosis …

Posted: Published on August 23rd, 2012

For each Teen BurgerTM sold in Canada , $1 will be given to the MS Society MONTREAL , Aug. 20, 2012 /CNW Telbec/ - For a fourth consecutive year, the Multiple Sclerosis Society of Canada invites Quebecers to join the fight against MS as part of its annual fundraising and awareness event, in collaboration with A&W Food Services of Canada Inc. (AW-UN.TO). How can I contribute? Exclusively on Thursday, August 23 , for each Teen Burger sold across the country, one dollar will be donated to help fight MS. The A&W Rendez-vous event will also feature several fundraising activities in participating restaurants, including games, raffles, prizes and even personal appearances by the Great Root Bear himself! Well-known personality Patricia Paquin will be at the Plateau-Mont-Royal A&W restaurant, located at 4501 St-Denis Street, between 11:30 a.m. and 1 p.m. Furthermore, until August 23: "The A&W Rendez-vous to end MS campaign greatly contributes to financing ongoing MS cause and treatment research, as well as services offered to Canadians suffering from this illness, which is diagnosed in three Canadians per day, explains Yves Savoie, President and CEO, MS Society of Canada . We are very grateful toward all donors, as well as A&W … Continue reading →

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Osteoporosis Clue Found In Stem Cell Signalling Protein

Posted: Published on August 23rd, 2012

Featured Article Academic Journal Main Category: Bones / Orthopedics Also Included In: Stem Cell Research Article Date: 23 Aug 2012 - 11:00 PDT Current ratings for: Osteoporosis Clue Found In Stem Cell Signalling Protein 1 (1 votes) These are the implications of a new study led by Harvard Medical School (HMS) that was published online in The Journal of Clinical Investigation on 13 August. Senior author Bjorn Olsen, Hersey Professor of Cell Biology at HMS, told the press about what they found: "It shifts the thinking about what controls the differentiation of stem cells to bone cells instead of fat cells, and how to make sure this mechanism stays active with aging." Bone is not a dead material: it is living tissue that is changing all the time, as it is continuously formed and reabsorbed. Osteoporosis is a common bone disease where bone tissue becomes progressively thinner, resulting in higher risk of fracture. It affects about 1 in 5 American women and is thought to be caused by stem cells that normally differentiate into bone-forming cells becoming fat cells instead over time. For the study, Olsen, who is professor of developmental biology and dean for research at Harvard School of … Continue reading →

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