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4th Annual Consumer Genetics Conference to Examine the Key Issues Facing Clinical Genetics, Personalized Medicine …

Posted: Published on August 3rd, 2012

Will Explore Major Advancements, Innovations, Challenges, and Evolving Business Models Newswise As advancements in genetic testing, personalized medicine and molecular diagnostics continue to reach new heights, they are also facing the growing pains and challenges of an emerging industry struggling with policy, regulatory framework, industry standards, and product commercialization. At the 4th Annual Consumer Genetics Conference, the fields preeminent researchers, clinicians, government regulators and industry leaders will provide their varying perspectives on this evolving field, and the crucial topics surrounding its implications to clinical health and medicine. In this highly interactive forum, panel participants will represent a broad spectrum of viewpoints, and will engage in an open discussion on best practices and policies, as well as new advancements and challenges. Through the course of this dynamic exchange, the future of consumer-based genetics will be explored, examined, and shaped. Major themes to be covered at this conference include: Big Data/Analysis, Molecular Diagnostics, Sequencing, Translational Genomics, Venture Capital and Investment Banking, Genome Data: The Physicians Perspective, Genome Interpretation, Visions for Personalized Medicine, Prenatal/Neonatal Diagnostics, Nutrition, Food Genetics and Cosmetics, Disease Diagnostics, The Empowered Patient, and Consumer Genetics Companies Please note, a significant discounted price to this conference is available until end-of-day August … Continue reading

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Personal Genetic Testing: Can DNA Discovery Go Mainstream?

Posted: Published on August 3rd, 2012

Winning government approval would be the first step in increasing public confidence in personalized genetic testing Maciej Frolow / Photodisc / Getty Images Earlier this week, the personal gene-testing company 23andMe announcedthat its seeking the blessing of the Food and Drug Administration (FDA) for its DNA tests that allow people to peer into their genetic makeup. If the FDA grants approval, it would be a major step forward for the growing industry springing up around genetic testing. Every day, it seems, scientists are reporting new gene-based discoveries that allow them to better pinpoint the causes of disease. As technology becomes increasingly sophisticated, single-gene tests are being joined by the sort of genotyping technology used by 23andMe, which scans about 1 million points on the genome that are known to vary among humans. An even more complex technique, genomic sequencing, looks at about 3 billion points that cover a persons entire genetic code. 23andMe the name is a reference to the 23 pairs of chromosomes that comprise a persons genome intends to eventually offer sequencing, but the cost starts at around $4,000, which is considerably more expensive than the $299 the company charges for its testing. Not only is sequencing more … Continue reading

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Stemcells, Inc. Reports Second Quarter 2012 Financial Results and Provides Business Update

Posted: Published on August 3rd, 2012

NEWARK, Calif., Aug. 2, 2012 (GLOBE NEWSWIRE) -- StemCells, Inc. (STEM), a leading stem cell company developing and commercializing novel cell-based therapeutics and tools for use in stem cell-based research and drug discovery, today reported financial results for the second quarter ended June 30, 2012 and provided a business update. "We continue to be encouraged by our progress in developing cell-based therapeutics for a broad array of disorders affecting the central nervous system," said Martin McGlynn, President and CEO of StemCells, Inc. "We have already reported top line results from our Phase I PMD trial and I am pleased to report that the manuscript with the complete PMD trial data is under peer review for publication by a top tier journal. Our other clinical development efforts also continue to advance. We recently reported interim safety data from our chronic spinal cord injury trial, showing that our cells and the procedure have been well tolerated. We have also initiated a Phase I/II trial in dry AMD and look forward to enrolling our first patients in this study soon. Lastly, we recently reported preclinical data showing that our cells restored memory in two animal models relevant to Alzheimer's disease without having to … Continue reading

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ACT Announces First Dry AMD Patient Treated with Higher Dosage of Embryonic Stem Cell-Derived RPE Cells

Posted: Published on August 2nd, 2012

MARLBOROUGH, Mass.--(BUSINESS WIRE)-- Advanced Cell Technology, Inc. (ACT; OTCBB: ACTC), a leader in the field of regenerative medicine, today announced treatment of the fourth patient, the first in the second patient cohort, in the companys Phase I/II clinical trial for dry age-related macular degeneration (dry AMD) using retinal pigment epithelial (RPE) cells derived from human embryonic stem cells (hESCs). The surgery was performed on Wednesday, Aug. 1 atWills Eye Institutein Philadelphia, by a surgical team lead by Carl D. Regillo, M.D., Chief of the Wills Eye Institute Retina Service, and professor of ophthalmology at Thomas Jefferson University. The patient was injected with 100,000 hESC-derived RPE cells and is recovering uneventfully. We are very pleased to have the second dose cohort in both of our U.S. clinical trials underway, commented Gary Rabin, chairman and CEO of ACT. We are encouraged by our ongoing progress in all three of our clinical trials using our hESC-derived RPE cells to treat forms of macular degeneration. We have not observed any complications or side effects from the stem cell-derived RPE cells, and we will continue to monitor the patients for safety, tolerability and efficacy of this therapy. The dry AMD trial is one of three … Continue reading

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Stem cells in tumors may fuel cancer regrowth, new studies suggest

Posted: Published on August 2nd, 2012

(AP) Why does cancer come back after a tumor has been seemingly eradicated? Three new studies from American, Belgian, British and Dutch researchers may have an answer. Study: Stem cells boost brain tumor treatments The studies bolster a long-debated idea that tumors contain their own pool of stem cells that can multiply and keep fueling the cancer, seeding regrowth. If that's true, scientists will need to find a way to kill those cells, apart from how they target and attack the rest of the tumor. Stem cells in healthy tissues are known for their ability to produce any kind of cell. The new research deals with a different kind, cancer stem cells. Some researchers, but not all, believe they lurk as a persisting feature in tumors. Over the past decade, studies have found evidence for them in tumors like breast and colon cancers. But this research has largely depended on transplanting human cancer cells into mice that don't have immune systems, an artificial environment that raises questions about the relevance of the results. Now, three studies reported online Wednesday in the journals Nature and Science present evidence for cancer stem cells within the original tumors. Again, the research relies on … Continue reading

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Autism researchers find that focusing on strengths improves social skills of adolescents

Posted: Published on August 2nd, 2012

ScienceDaily (Aug. 1, 2012) The junior high and high school years are emotionally challenging even under the best of circumstances, but for adolescents with autism spectrum disorders (ASD), that time can be particularly painful. Lacking the social skills that enable them to interact successfully with their peers, these students are often ostracized and even bullied by their classmates. However, a new study conducted by researchers at the Koegel Autism Center at UC Santa Barbara has found that by playing on their strengths -- high intelligence and very specific interests -- these adolescents are as capable as anyone else of forging strong friendships. In addition, the research findings demonstrate that the area of the brain that controls such social behavior is not as damaged in adolescents with ASD as was previously believed. The findings appear in a recent issue of the Journal of Positive Behavior Interventions. "The problem is that their restricted interests can dominate their lives and further push away people they'd like to get to know," said Robert Koegel, director of the Koegel Autism Center and the study's lead author. He is also a professor of counseling, clinical, and school psychology and of education in UCSB's Gevirtz Graduate School … Continue reading

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Stroke recovery prediction tool created

Posted: Published on August 2nd, 2012

A new set of tests can help predict whether an individual patient will recover the use of their hand and arm after a stroke, report New Zealand researchers. Neuroscience Professor Winston Byblow, from the University of Auckland, and colleagues, report their findings in the current issue of the journal Brain. "This is the first demonstration that there is a combination of techniques that can be used to predict an individual patient's chance of recovery," Byblow tells the Australian Broadcasting Corporation. "Knowing the difference between who will make some recovery and who will make none is information that the therapists have been asking for a long time." After a stroke interrupts blood supply to the brain, many people are left unable to use their hand and arm properly, with some limbs being completely paralysed. But, says Byblow, it is very difficult to predict how well an individual will recover with the help of therapy, and who has been damaged beyond the point of no return. "The very challenging part is you can examine two patients within days of their stroke and they can look exactly the same, but one will make a perfect recovery and one will make no recovery," he … Continue reading

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Caffeine may ease Parkinson's symptoms, suggests research

Posted: Published on August 2nd, 2012

Caffeine consumption may help control movement in people suffering from Parkinson's, according to new research. Consumption of caffeine could reduce the symptoms of Parkinson disease by aiding control of movement, say the researchers. The study published in Neurology investigated the effects of caffeine on Parkinson disease symptoms, noting that whilst epidemiologic studies have consistently linked caffeine consumption to a lower risk of the disease, research into the symptomatic effects of caffeine in Parkinsons have not been adequately evaluated. "This is one of the first studies to show the benefits of caffeine on motor impairment in people who have Parkinson's disease," said Dr Ronald Postuma, lead author of the study. "Research has already shown that people who drink coffee have a lower risk of developing Parkinson's disease, but until now no study had looked at the immediate clinical implications of this finding," said the lead researcher, who is based at McGill University, Canada. This is one of the first studies in humans to show that caffeine can help with movement symptoms for people who already have the disease." Postuma noted that the results of the study open the door to potential new therapies for the symptoms of Parkinsons. Wake-up call? Caffeine … Continue reading

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Caffeine helps Parkinson’s patients move: study

Posted: Published on August 2nd, 2012

Drinking coffee may help people with Parkinsons disease move with greater ease, although getting steady jolts of caffeine doesnt appear to alleviate the daytime sleepiness that affects certain patients, a study suggests. In the Canadian-led study, researchers set out to see if caffeine could help overcome whats called daytime somnolence, a symptom that affects some patients with the progressive neurological disease. While they didnt find an appreciable wake-up effect among subjects taking caffeine, the researchers were surprised to find that javas main ingredient appeared to enhance patients mobility. What was significant was the movement improvement, said principal investigator Dr. Ronald Postuma, a neurologist at McGill University Health Centres research institute. And this was present both on motor symptoms, but also on the objective scoring in the motor exam. To conduct the study, 61 people with Parkinsons disease who showed symptoms of daytime sleepiness and some motor impairment were randomly assigned to receive either a placebo pill or a caffeine tablet. Participants chosen for the study were not big coffee drinkers on average, they drank only about one cup per day. Those in the treatment group took a pill containing 100 milligrams of caffeine twice daily for three weeks, then 200 … Continue reading

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Cerebral palsy boy never gives up Save

Posted: Published on August 2nd, 2012

Aug. 2, 2012, 11:46 a.m. DANIEL Fairclowgh has never let cerebral palsy stop him doing what he loves and is encouraging those with the condition to do the same and never give up. National Cerebral Palsy Awareness Week, from July 30 to August 5, is an opportunity for the strength and needs of people like Daniel to be put in the spotlight. Daniel was born with the physical condition which affects the movement on the left-hand side of his body. Having the condition causes the Falcon Primary School student to experience weakness, stiffness and sometimes involuntary movements which can often cause tightness and pain in his left arm. Daniels mum Sandra Lavender said she first noticed something was wrong when he was four months old and his left hand seemed to be clenched. At six months Daniel was diagnosed with dystonic hemiplegia which is the most common form of cerebral palsy affecting more than one million children under 21 worldwide. For most people with cerebral palsy the cause is unknown but Ms Lavender said it can be caused by lack of oxygen to the baby's brain before or during pregnancy. According to the Cerebral Palsy Alliance the most common cause … Continue reading

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