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Protecting prion protein keeps stem cells young

Posted: Published on August 17th, 2012

COULD we stem the tide of ageing by delaying the deterioration of stem cells? A new compound that appears to do just that could help us find ways to protect our organs from age-related wear and tear, experiments in mice suggest. As we age, so do our mesenchymal stem cells (MSCs): their numbers in our bone marrow decline, and those that are left lose the ability to differentiate into the distinct cell types - such as bone, cartilage, fat and possibly muscle cells - that help in the healing process. "We think this ageing of stem cells may be linked to the onset of some age-related disorders, such as osteoporosis," says Ilaria Bellantuono at the University of Sheffield in the UK. Earlier research in mice had suggested that the prion protein expressed by MSCs might play a role in holding back stem cell ageing. Mice lacking the prion protein were less able to regenerate blood cells. The study provided more evidence that correctly folded prions serve a useful purpose in the body, despite the role that misfolded prions play in BSE and vCJD. Bellantuono and her colleagues have now found that the prion protein performs a similar function in humans … Continue reading

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Experimental cancer drug makes mice infertile without side effects, scientists claim male birth control discovery

Posted: Published on August 17th, 2012

(CBS News) A male birth control pill advanced one step closer to reality, a team of cancer and fertility researchers announced Thursday after their latest discovery. Prescription drugs that lead double lives Sperm gene discovery may lead to male birth control, scientists say Scientists had been researching a small molecular compound called JQ1, which was meant to block a cancer-causing gene called "BRD4." The compound had previously been shown effective in staving off lung cancer and blood cancers, like leukemia and multiple myeloma, in earlier studies. Part of the problem with finding a male birth control pill is the challenge of getting a drug across the blood-testis barrier. Just like the blood-brain barrier regulates what cells and compounds come in and out of the brain, the blood-testis barrier physically separates blood vessels and the sperm-producing seminiferous tubules that are found in the testes. That's when Dr. James Bradner, an oncology researcher at the Harvard-affiliated Dana-Farber Cancer Institute in Boston who had been researching JQ1, wanted to see if the molecule was small enough to cross the blood-testis barrier. He was curious if the compound would affect the BRDT sperm-producing gene associated with that family of proteins he'd been researching for … Continue reading

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Brand inspires drugs rehab gift

Posted: Published on August 17th, 2012

17 August 2012 Last updated at 09:49 ET A Suffolk drugs treatment charity says it has received a donation of 106,000 as a result of a Russell Brand television documentary. Focus 12, which is based in Bury St Edmunds, was featured in Addiction To Recovery on BBC Three on Thursday. The charity said it was reliant donations to help meet the 500,000 a year cost of running its centre. Local firm Chevington Finance & Leasing said it was inspired by the programme to provide the new funding. Russell Brand credits the charity with helping him end his heroin addiction. The business is donating a one-off 10,000, followed by 2,000 every month for four years. Chief executive Chip Somers, who featured in the comedian's documentary, said: "We got an incredible phone call almost the moment we opened this morning. "Raising funds for a recovery charity has never been harder, every day is a struggle to keep afloat and we are very grateful to Chevington for their intervention. "Having that money coming in regularly over four years allows us to really balance the cash flow and plan ahead." Continued here: Brand inspires drugs rehab gift … Continue reading

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Pharmacy robbed in Newport

Posted: Published on August 17th, 2012

View Larger Map By DOUG HARLOW Staff Writer NEWPORT Police are looking for a man who robbed the Rite Aid pharmacy last night on Moosehead Trail in the towns triangle business district off U.S. Route 2 and state Route 100. click image to enlarge Police are looking for the man in this security camera photo who robbed the Rite Aid pharmacy of drugs in Newport Thursday evening. Newport Police Chief Leonard Macdaid said a man wearing a black skull cap and sunglasses entered the store about 5:30 p.m. Thursday. He handed the employee a note and left with an undisclosed quantity of drugs. Macdaid said no one was injured and the clerk did not see a weapon. Macdaid said the robber, who left on foot, was white, about six feet tall and wore a black jacket and tan pants. He declined to say what kind of drugs were taken. Were just summing up leads right now and I dont want to give out too much, he said. Read more from the original source: Pharmacy robbed in Newport … Continue reading

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Mass. pharmacy tech accused of stealing pills

Posted: Published on August 17th, 2012

NORTH ATTLEBOROUGH, Mass.A pharmacy technician at a North Attleborough drug store has been charged with stealing more than 4,000 prescription pills while on the job. Police say 31-year-old Catherine Bryant was captured on video surveillance slipping painkillers and other pills usually prescribed to treat opiate addiction into her work smock on various days from Aug. 6 to Wednesday. Police say she had more than 40 pills in her possession when she was arrested. She was freed on $5,000 bail after pleading not guilty at her arraignment Thursday in Attleboro District Court. The Sun Chronicle ( http://bit.ly/Omx3bg) reports that her lawyer said the number of pills reported stolen was "exaggerated." Bryant, who has no prior arrest record, told police she suffers from lupus and stole the pills for personal use to alleviate her pain. Information from: The (Attleboro, Mass.) Sun Chronicle, http://www.thesunchronicle.com Copyright 2012 Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed. Read the rest here: Mass. pharmacy tech accused of stealing pills … Continue reading

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U.S. Navy Awards Multi-Million Dollar Contract to Innovation for Pharmacy Automation Technologies

Posted: Published on August 17th, 2012

JOHNSON CITY, N.Y., Aug. 17, 2012 /PRNewswire/ --Innovation, makers of PharmASSISTpharmacy automation solutions, today announced that the U.S. Navy has awarded the company a 5-Year Indefinite Delivery/Indefinite Quantity contract up to $49 million to supply pharmacy automation technologies to U.S. Navy high-volume sites and outpatient pharmacies around the world. According to the U.S. Navy, Innovation was the only company who fully met the technical requirements of their published Generic Functional Systems Requirement (GFSR). (Logo: http://photos.prnewswire.com/prnh/20110719/NE37772LOGO) "Innovation is pleased that the U.S. Navy has awarded us this significant contract to upgrade their pharmacies' prescription fulfillment processes and quality control," said Mary Reno, CEO, Innovation. "We look forward to this opportunity to assist Navy pharmacies in achieving their goal of standardized workflow and dispensing platforms. Most importantly, our various technologies will help Navy pharmacies reach the specific quality objectives that they require to ensure the utmost in patient safety for our service men and women." The main objectives of this U.S. Navy initiative are to: U.S. Navy hospitals previously acquired their pharmacy automation systems individually. The new contract calls for central acquisition and management to enable U.S. Navy outpatient pharmacies to implement a standardized pharmacy automation system throughout the life of the … Continue reading

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Ren Elder Appointed Head of Pharmacy for Aetna

Posted: Published on August 17th, 2012

HARTFORD, Conn.--(BUSINESS WIRE)-- Aetna (NYSE: AET) announced today that Ren Elder has been appointed head of Pharmacy for Aetna, Inc. In this role, Elder will have responsibility for Aetnas Pharmacy business including Specialty Pharmacy Disease Management and Aetna Rx Home Delivery. Elder will help to further develop Aetnas Pharmacy Benefit Management integrated capabilities as well as manage Aetnas strategic agreement with CVS Caremark. Elder joins Aetna from WellPoint, Inc., where he served as the President of NextRx, WellPoints pharmacy business. In that role, he oversaw mail order delivery and specialty pharmacy facilities. He also was responsible for the companys retail pharmacy network relationships. We are thrilled to have Ren join Aetna at such an important time for our company and our health care system, said Jeff Emerson, head of Aetna Health Care Management. Our integrated pharmacy benefits can assist our members in safely taking their medications, helping them live safer, healthier lives. Rens leadership will help to further our work to achieve these goals. The opportunity to join a Pharmacy team that already has a successful track record of providing high-quality care is exciting, said Elder. Aetna is committed to improving the way health care is delivered. I look forward … Continue reading

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The Son-Rise Program – Themes, Activities, and Games – Video

Posted: Published on August 17th, 2012

15-08-2012 10:57 A great toy that you can take into your Son-Rise Program playrooms to encourage verbal communication, expressive language, and physical participation with your child on the Autism Spectrum. Continued here: The Son-Rise Program - Themes, Activities, and Games - Video … Continue reading

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'I will never live a normal life': Brain-damaged British bride reveals extent of her injuries after freak accident in …

Posted: Published on August 17th, 2012

Natalie Creane, 33, was left seriously injured after a TV panel fell on her head at the Emirates Palace Hotel in 2008 Incident has left her suffering epileptic seizures and traumatic brain injury By Tahira Yaqoob PUBLISHED: 02:42 EST, 16 August 2012 | UPDATED: 13:34 EST, 16 August 2012 Legal action: Natalie Creane was left with a life-threatening brain condition after a TV panel fell on her head in a five-star hotel four years ago The British newlywed left with a life-threatening brain condition after a TV panel fell on her head in a five-star hotel has spoken for the first time about her four-year ordeal. Natalie Creane, 33, said she cannot be left alone after the incident in the Emirates Palace Hotel in Abu Dhabi left her suffering epileptic seizures and a traumatic brain injury. She said: 'I do not live a normal life and I never will.' As she can only walk and talk with great difficulty, Mrs Creane took a week to articulate the trauma of the past four years. During that time she has been locked in a battle for compensation with the Emirates Palace hotel. She suffered a string of debilitating injuries when a TV … Continue reading

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Saskatchewan man chosen for MS liberation therapy trial in U.S.

Posted: Published on August 17th, 2012

A Saskatchewan man who is going to the U.S. to see if he can take part in the so-called liberation treatment for multiple sclerosis says hes both terrified and excited. Andrew Dahlen is the first Saskatchewan resident to go to Albany, N.Y., for the final eligibility screening in a two-year, double-blind clinical trial. The province is putting up $2.2 million to have 86 Saskatchewan patients take part. The nature of the double-blind study means half of those participating in the trial will receive liberation therapy and half will get a placebo procedure. Dahlen says even if he were to get the placebo that would still be good research on the progression of MS. The 28-year-old Saskatoon music lover, who lost the ability to play guitar because of the disease, also says the possible benefit would outweigh the risks. The therapy was devised by Italian physician Paolo Zamboni, who has suggested MS may be caused by narrowed veins that prevent blood from properly draining from the brain. He says that could result in iron deposits that damage neurons. Zamboni calls the condition chronic cerebrospinal venous insufficiency, or CCSVI. Zambonis treatment uses balloon angioplasty to open the veins in the same way … Continue reading

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