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Caffeine from two to four daily cups of coffee may reduce Parkinson's disease symptoms

Posted: Published on August 2nd, 2012

(CBS News) Should doctors start prescribing coffee? In the latest study to tie coffee to health benefits, new research finds a daily caffeine boost may ease symptoms of Parkinson's disease in sufferers. Why am I so awake? 12 surprising sources of caffeine Study: Drinking coffee reduces overall death risk Parkinson's is a degenerative brain disease that causes tremors, difficulty with walking, movement and coordination. The condition most commonly develops in adults over 50, and occurs when nerve cells in the brain that make the muscle-controlling neurotransmitter dopamine are slowly destroyed, leading to loss in muscle function. The cause of the disease remains unknown. The study, published August 1 in the online issue of Neurology, tracked 61 people with Parkinson's who were exhibiting symptoms of daytime sleepiness. Participants were assigned to receive either a placebo pill twice per day or a 100 milligram-caffeine pill twice per day for three weeks. After three weeks, those in the caffeine group were given a 200 milligram caffeine pill twice per day, about the caffeine equivalent found in two to four cups of coffee. Six weeks into the study, people taking the caffeine pills averaged a five-point improvement on a ratings scale of Parkinson's symptom … Continue reading

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Coffee may help some Parkinson's disease movement symptoms, research suggests

Posted: Published on August 2nd, 2012

ScienceDaily (Aug. 1, 2012) While drinking coffee with caffeine each day does not appear to reduce sleepiness among people with Parkinson's disease, it may have a benefit in controlling movement, according to new research published in the August 1, 2012, online issue of Neurology, the medical journal of the American Academy of Neurology. "Studies have shown that people who use caffeine are less likely to develop Parkinson's disease, but this is one of the first studies in humans to show that caffeine can help with movement symptoms for people who already have the disease," said study author Ronald Postuma, MD, MSc, with McGill University in Montreal and the Research Institute of the McGill University Health Center. Postuma is also a member of the American Academy of Neurology. For the study, 61 people with Parkinson's disease who showed symptoms of daytime sleepiness and some motor symptoms were given either a placebo pill or a pill with 100 milligrams of caffeine two times a day for three weeks, then 200 milligrams twice a day for three weeks, which was the equivalent of between two and four cups of coffee per day. After six weeks, the half that took the caffeine supplements averaged … Continue reading

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Caffeine could help some Parkinson’s symptoms

Posted: Published on August 2nd, 2012

CTVNews.ca Staff Published Wednesday, Aug. 1, 2012 2:01PM EDT Last Updated Wednesday, Aug. 1, 2012 5:02PM EDT Drinking caffeine each day might help Parkinsons patients move a little easier, making their walking more fluid and improving their quality of life, new Canadian research has found. The researchers say the improvements are small, but their research suggests theres something about caffeine that blocks malfunctioning brain signals in Parkinsons patients. The finding was a surprising one and came during a study to test caffeine as a treatment for daytime sleepiness among Parkinsons patients. Though it didnt do much for keeping fatigue at bay, it did seem to help with movement. The study looked at 61 people with Parkinsons disease with symptoms of daytime sleepiness as well as the tremors, rigidity and slow movement that marks the brain disease. The volunteers were given either a placebo pill or a pill with 100 milligrams of caffeine, twice a day for three weeks. The dose was then bumped up to 200 milligrams twice a day for three weeks -- the equivalent of between two and four cups of coffee per day. The researchers report in the journal Neurology that the caffeine didnt really help improve … Continue reading

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Caffeine may help in Parkinson's treatment: study

Posted: Published on August 2nd, 2012

Parkinson's breakthrough is found with caffeine pills a new study shows. Researchers at McGill University in Montreal found that just a few cups of coffee per day helped relieve shaking and trembling experienced by those with the disease. HealthDay reported that the small study of 61 individuals showed that having about three cups of coffee per day improved patients motor skills and reduced stiffness. The so-called "cups" were actually caffeine pills taken three times per day and meant to mimic the real thing, said Reuters. More from GlobalPost:Michael J. Fox talks about Parkinson's cure and stem cell research (VIDEO) "Caffeine treats Parkinson's disease," said study author, Ronald Postuma, of McGill University, reported the Daily Mail. "There was a modest effect on sleepiness that didn't reach statistical significance, but I think it was clear that it helps patients. Researchers were cautiously optimistic given the improvement was only mild. "Where we saw the most potential benefit from caffeine was on motor aspects and symptoms," said Postuma, according to HealthDay. "People felt better and were more energetic. You could see on the exam that they were better." Originally posted here: Caffeine may help in Parkinson's treatment: study … Continue reading

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Study: Java May Help Ease The Jitters in Parkinson's Patients

Posted: Published on August 2nd, 2012

Earlier this year, a large-scale study found that coffee drinkers live longer than those who don't imbibe in daily lattes. Now a new study has found the caffeine in a cup of coffee might be as effective as some drugs at treating certain symptoms of Parkinson's disease. While a cup of Joe might make most of us feel jittery, it has the opposite effect on people suffering from Parkinson's disease. Researchers found caffeine can temporarily improve motor function in people suffering from the disease, according to a randomized, placebo-based trial published in the journal Neurology on Wednesday. [Deep Brain StimulationMay Offer Long-Term Parkinson's Relief] "It's not like we get with the best medications to treat Parkinson's, but [caffeine's] effects seem to be as good as some of the less powerful drugs," says lead researcher Ronald Postuma, of McGill University in Montreal. Parkinson's disease is a degenerative nervous system disorder that affects as many as 60,000 new patients in the United States each year and is associated with unintended shaking, balance trouble, and energy problems. According to the Centers for Disease Control, it's the 14th leading cause of death in the United States. In the study, 30 Parkinson's sufferers took between … Continue reading

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Cancer Stem Cells Really Do Exist?

Posted: Published on August 2nd, 2012

In April, The Scientist asked, Are Cancer Stem Cells Ready for Prime Time? The controversial hypothesis posits that cells with stem-cell-like characteristicssuch as the ability to self-renew and give rise to more tumor cellscontribute to cancers ability to evade traditional therapies. But despite previous investigations, which found subsets of tumor cells with the ability to grow in immunocompromised mice, not everyone is convinced that endogenous tumor development is stimulated by cells with self-renewal capacity. Now, using genetic labeling techniques, three new studies trace cell lineages in new tumors to provide strong evidence for the existence of cancer stem cells. Published today (August 1) in Nature and Science, the technically elegant studies provide support for the cancer stem cell model across three different types of solid tumorsskin, intestinal, and brainsaid Max Wicha, an oncologist at the University of Michigan who helped develop the cancer stem cell hypothesis and in 2004 co-founded OncoMed Pharmaceuticals to develop therapies targeting cancer stem cells, but was not involved in the research. The cancer stem cell hypothesis states that cells in tumors display a similar hierarchy to normal tissues that are renewed by stem cells, like the skin or intestinal epithelium, explained Sunit Das, a neurobiologist … Continue reading

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Infectious Boyd Melson making difference in spinal cord research, one fight at a time

Posted: Published on August 1st, 2012

Boyd Melson is on the other end of the telephone, talking. And talking. And talking. He sounds like a football coach pulling out the "Win one for the Gipper," speech. He's "obsessed," he says in one breath, about finding a way to help those with chronic spinal cord injuries to get out of their wheelchairs and walk, and to see them resume normal lives. "Can you imagine how great that would be?" he says, without giving one an option to think anything but, yes, that would be the greatest thing ever. In the next breath, he's talking about his fighting career and his ambition to win a world title. Anyone who understands professional boxing and knows the type of commitment it demands, the sacrifices it requires, and the skill it takes, knows it's a pipe dream. Melson is 30 and has a full-time job at Johnson & Johnson, as well as what amounts to a full-time job as a fund-raiser. As he's talking, it seems like he's doing two or three other things at once. He barely has the time to commit to a telephone conversation, let alone a fight career. Melson, though, is a true believer. No one does … Continue reading

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Story of abuse at brain-injury center demands action

Posted: Published on August 1st, 2012

By ROSEMARY GOUDREAU | Florida Voices Published: August 01, 2012 Updated: August 01, 2012 - 12:00 AM It is impossible to look at the pages-long list of abuse allegations from a Central Florida facility for people with brain injuries and not wonder how the Florida Institute for Neurologic Rehabilitation is allowed to remain open. Sexual abuse. Mental abuse. Burns. Broken bones. Bruises. Cuts and punctures. Bizarre punishment. Excessive restraints. Inadequate supervision. Confinement. Exploitation. Harassment, belittlement, ridicule. Beatings. Asphyxiation. And death. Five times, death. Since 2005, state investigators have received 477 allegations of adults and children abused at FINR. In one month alone, the institute racked up 10 calls to the Florida Abuse Hotline. Not infrequently, it's gotten six, seven or eight abuse-hotline calls a month. It's hard to hear the stories from one of the nation's largest brain-treatment facilities, tucked in Wauchula, 50 miles southeast of Tampa. People like Peter Price, who swallowed five fish hooks and 22 AA batteries to facilitate his escape. Or Janet Clark, who keeps a picture of herself after she was "kicked in the eye with a boot." Or watch the video of a man who is picked off the couch by a staffer and … Continue reading

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Possible clue to progression of multiple sclerosis

Posted: Published on August 1st, 2012

ScienceDaily (July 31, 2012) Wayne State University School of Medicine researchers, working with colleagues in Canada, have found that one or more substances produced by a type of immune cell in people with multiple sclerosis (MS) may play a role in the disease's progression. The finding could lead to new targeted therapies for MS treatment. B cells, said Robert Lisak, M.D., professor of neurology at Wayne State and lead author of the study, are a subset of lymphocytes (a type of circulating white blood cell) that mature to become plasma cells and produce immunoglobulins, proteins that serve as antibodies. The B cells appear to have other functions, including helping to regulate other lymphocytes, particularly T cells, and helping maintain normal immune function when healthy. In patients with MS, the B cells appear to attack the brain and spinal cord, possibly because there are substances produced in the nervous system and the meninges -- the covering of the brain and spinal cord -- that attract them. Once within the meninges or central nervous system, Lisak said, the activated B cells secrete one or more substances that do not seem to be immunoglobulins but that damage oligodendrocytes, the cells that produce a … Continue reading

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Intellect Neurosciences Adds Two New Patent Allowances to Its Global Patent Portfolio

Posted: Published on August 1st, 2012

NEW YORK, Aug. 1, 2012 (GLOBE NEWSWIRE) -- Intellect Neurosciences, Inc. (ILNS), a biopharmaceutical company engaged in the discovery and development of disease-modifying therapeutic agents for the treatment of Alzheimer's and other neurological diseases, today announced it obtained a Notice of Allowance from the European Patent Office (EPO) for OX1, which has been licensed to ViroPharma for Friedrich's Ataxia and other neurodegenerative diseases. Separately, the company received a similar notice from the Israeli patent office for the RECALL-VAX platform technology that underlies RV03, its first-in-class bi-specific vaccine targeting beta amyloid and delta tau for the treatment and prevention of Alzheimer's disease. The OX1 patent relates to a new salt form found to be useful to increase the purity of the compound during manufacture. The new patent potentially extends the patent coverage in Europe by several years. Corresponding patent applications are pending in the United States and Japan. RECALL-VAX is a chimeric peptide vaccine used to produce highly specific immune responses and to avoid potential autoimmune responses. Its lead candidate, RV03 is a preclinical, first-in-class, dual acting peptide vaccine designed to induce an immune response against beta amyloid and delta tau. Delta tau is thought to be a pathological form of … Continue reading

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