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Stemedica Takes Part in Mexican Clinical Trial

Posted: Published on June 1st, 2012

Stem cells provided by San Diego-based Stemedica Cell Technologies Inc. are expected to be used soon in a phase I/II clinical trial for chronic heart failure in Mexico. Stemedica announced May 29 that its strategic Mexico partner, Grupo Angeles Health Services, has received approval for a single-blind randomized clinical trial from Mexicos FDA equivalent regulatory agency, COFEPRIS. The trial being conducted at multiple hospital sites throughout Mexico will involve Stemedicas adult allogeneic ischemia tolerant mesenchymal stem cells delivered via intravenous infusion. The trial will involve three safety cohorts at different dosages, followed by a larger group being treated with the maximum safe dosage. The trial, set to begin on or before July 1 with 60 to 80 patients, is one of only two studies using allogeneic stem cells approved by COFEPRIS. The other study approved in 2010 was a clinical trial for ischemic stroke. We are pleased that we will be working with the largest and most prestigious private medical institution in Mexico to study Stemedicas product for this indication, said Stemedica CEO Maynard Howe in a statement. If successful, our stem cells may provide a treatment option for the millions of patients, both in Mexico and internationally, who suffer … Continue reading

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Hospital's epilepsy program given top designation

Posted: Published on June 1st, 2012

By Kim Walter -- kwalter@nvdaily.com The Virginia Comprehensive Epilepsy Program in Winchester was recently named a Level 4 Epilepsy Center by the National Association of Epilepsy Centers, making it one of three in the state with the top designation. The program is a collaboration of the Winchester Medical Center and two local practices, Winchester Neurological Consultants, Inc. and Virginia Brain and Spine Center, Inc. Being named a level 4 center means it provides intensive testing, monitoring and treatment options to patients of all ages. Dr. Paul Lyons, a neurologist and epileptologist, and Dr. Lee Selznick, a neurosurgeon, work closely as a team with patients, from diagnosis to treatment and recovery. "About one percent of the population is affected by epilepsy ... it's not a rare condition," Lyons said. It is the third most common neurological disorder in the United States, yet epilepsy is also among the least understood of major chronic medical conditions. "The cornerstone of treatment for epilepsy is an accurate diagnosis," he said. To assure a patient is properly diagnosed, Winchester's program conducts rigorous testing and evaluations. Lyons said that once diagnosed, it still has to be determined what kind of medication is best for that particular patient. … Continue reading

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Autism experts will convene in Mt Pleasant for the 2012 Lowcountry Autism Forum

Posted: Published on June 1st, 2012

Credit: WSAV National, state and local autism experts will convene at the "2012 Lowcountry Autism Forum," Saturday, June 16, at Seacoast Church, 750 Long Point Road in Mt. Pleasant, 9:00 a.m. - 4:00 p.m. By: News Release | WCBD News 2 Published: May 31, 2012 Updated: May 31, 2012 - 3:52 PM Mt. Pleasant, SC - National, state and local autism experts will convene at the "2012 Lowcountry Autism Forum," Saturday, June 16, at Seacoast Church, 750 Long Point Road in Mt. Pleasant, 9:00 a.m. - 4:00 p.m. The admission-free event is open to the public. News 2's Carolyn Murray will be the emcee for the morning session. Physicians, therapists and software vendors will also participate in the forum sponsored by the Lowcountry Autism Spectrum Disorders Consortium (LASD) and MUSC Project REX, an outpatient treatment program for children with autism. Keynote speakers at the forum will include Dr. Joe Horrigan, Assistant Vice President and Head of Medical Research and Leslie Long, Director of Housing and Adult Services, both from Autism Speaks, the nations largest autism science and advocacy organization. Some other speakers are: Dr. Carol Page, Director, South Carolina Assistive Technology Program, USC School of Medicine; Dr. Jane Charles, MUSC … Continue reading

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New treatment for irritability in autism

Posted: Published on June 1st, 2012

Public release date: 31-May-2012 [ | E-mail | Share ] Contact: Rhiannon Bugno biol.psych@utsouthwestern.edu 214-648-0880 Elsevier Philadelphia, PA, May 31, 2012 Autism is a developmental disorder that affects social and communication skills. Irritability is a symptom of autism that can complicate adjustment at home and other settings, and can manifest itself in aggression, tantrums, and self-injurious behavior. These disruptive behaviors are frequently observed in children with autism, which may considerably affect their ability to function at home or in school. N-acetylcysteine (NAC) is approved by the US Food and Drug Administration for the treatment of acetaminophen (Tylenol) overdoses, but it may have other applications related to its effects in the brain. NAC helps maintain and restore glutathione, which play a key role in the antioxidant defense system. Additionally, cysteine as supplied by NAC treatment, stimulates a protein, the cystine-glutamate antiporter, resulting in the decrease of glutamatergic neurotransmission. NAC has two resulting effects: 1) it may protect brain cells by raising the level of a protective antioxidant metabolite called glutathione, and 2) it may reduce the excitability of the glutamate system by stimulating inhibitory receptors. These drug actions are important because, although the causes of autism are unknown, it is clear … Continue reading

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The MED Earns Get With The Guidelines-Stroke Silver Plus Quality Achievement Award

Posted: Published on June 1st, 2012

College Station Medical Center (The MED) has received the American Heart Association/American Stroke Associations Get With The Guidelines-Stroke Silver Plus Quality Achievement Award. The award recognizes The MEDs commitment and success in implementing a higher standard of stroke care by ensuring that stroke patients receive treatment according to nationally accepted standards and recommendations. In earning the award, The MED achieved at least 12 consecutive months of 85 percent or higher adherence to all Get With The Guidelines-Stroke Quality Achievement indicators and achieved at least 75 percent or higher compliance with six of 10 Get With The Guidelines-Stroke Quality Measures during that same period of time, which are reporting initiatives to measure quality of care. These measures include aggressive use of medications, such as antithrombotics, anticoagulation therapy, DVT prophylaxis, cholesterol reducing drugs and smoking cessation, all aimed at reducing death and disability and improving the lives of stroke patients. In addition to the Get With The Guidelines-Stroke award, The MED has also been recognized as a recipient of the associations Target: Stroke Honor Roll, for improving stroke care. Over the past quarter, at least 50 percent of the hospitals eligible ischemic stroke patients have received tissue plasminogen activator, or tPA, within … Continue reading

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Women with irregular heart rhythm carry a higher risk of stroke than men

Posted: Published on June 1st, 2012

Public release date: 31-May-2012 [ | E-mail | Share ] Contact: Stephanie Burns sburns@bmjgroup.com 44-207-383-6920 BMJ-British Medical Journal Women with irregular heart rhythm (known as atrial fibrillation) have a moderately increased risk of stroke compared with men, suggesting that female sex should be considered when making decisions about anti-clotting treatment, finds a study published on bmj.com today. Several studies have suggested that women with atrial fibrillation are at higher risk for ischaemic stroke (caused by an interruption of the blood supply to the brain) than men, but other studies found no such difference. If few or no other stroke risk factors exist, doctors need to know whether female sex is important in making decisions about anti-clotting treatment. So researchers based at the Karolinska Institute in Sweden and the University of Birmingham in the UK decided to investigate whether women with atrial fibrillation have higher risk of stroke than men. The study involved over 100,000 patients with a diagnosis of atrial fibrillation at any Swedish hospital or hospital affiliated outpatient clinic. Participants were tracked for an average of 1.2 years (a total of 139,504 years at risk - a term that adds up the time each person in the study was … Continue reading

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The scurry for a spinal injuries cure

Posted: Published on June 1st, 2012

Step toward cure: A treatment which has allowed paralysed rats to walk again could be developed to help human victims of spinal injury. Source: Supplied IT WAS one small step for a rat, but it may be one giant leap for mankind. Rats paralysed by spinal injuries have learned to walk, and run, again after groundbreaking treatment which awakens the spinal brain and helps the spine to repair itself. Australian experts yesterday hailed the successful research as bringing science to the edge of a truly profound advance in modern medicine by allowing paralysed people to walk again. Swiss scientists who have spent five years investigating how the brain and spine can adapt to injury, injected a chemical solution into the rats which stimulated neurons in their spines. The cocktail of drugs, aided by electrical stimulation, strengthened the signals normally sent by the brain down the spinal cord in healthy rats, and when the tests rats, which had severely damaged, but not completely severed, spinal cords, were placed in special harnesses, they could walk. After a couple of weeks of neurorehabilitation with a combination of a robotic harness and electrical-chemical stimulation, our rats are not only voluntarily initiating a walking gait, … Continue reading

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Paralyzed Rats Regain Strut

Posted: Published on June 1st, 2012

After severe spinal cord damage, paralyzed rats are able to walk again with the help of a robot to hold them up and stimulate their nerves, a new study shows. After the rats are trained on the machine for about two months, they gained the ability to control their hind legs -- which had previously been cut off from communicating with the brain -- with enough dexterity to climb stairs and navigate around objects. This control means that the brain has forged new connections to get around the spinal cord injury. NEWS: Bionic Suit Helps Paralyzed Woman Complete Marathon "We expected they would recover to some degree, but the extent was amazing. They were able to avoid obstacles and walk up stairs," study researcher Janine Heutschi, of the Swiss Federal Institute of Technology in Switzerland, told LiveScience. "Not only that, but the consistency was really amazing. Every single animal we trained in this robot was able to perform these tasks." What this means for humans is unclear, but the team is working to adapt the procedure for clinical trials. Paralyzed Rats The researchers simulated spinal cord damage in the rats by making two cuts halfway through the spinal cord; the … Continue reading

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Experiment lets spine-injured rats walk, climb

Posted: Published on June 1st, 2012

NEW YORK Many scientists are working on treatments to help people with spinal cord injuries walk. Now there's a striking new demonstration of how one approach might work: Spinal nerve stimulation helped rats in a Swiss lab overcome paralysis to walk and climb stairs. That may sound impressive, but similar progress has been made in people, too. The difference this time is the particular technique used. "It's a natural extension of exciting work that's been done by many groups," said Dr. John McDonald, director of the International Center for Spinal Cord Injury at Kennedy Krieger Institute in Baltimore. He wasn't involved in the research. In the new experiment, reported in Friday's issue of the journal Science, researchers stimulated spinal nerve circuits and used physical training. The stimulation was electrical current from implanted electrodes plus injections of a chemical mix. To do the training, the rats were placed in a harness so that only their hind legs reached the ground. Then they were placed on a treadmill, which produced only reflexive stepping, and on stationary ground, where they had to choose to make their legs move if they wanted to reach a piece of chocolate. They took their first voluntary steps … Continue reading

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Paralyzed Rats Walk Again

Posted: Published on June 1st, 2012

May 31, 2012 2:53pm Paralyzed rats could walk again after scientists in Switzerland treated their injured spinal cordsthrough a combination of chemical, electrical and physical stimulation. Gregoire Courtine, the studys lead author, said the techniquewould not completely cure a spinal cord injury, but the study gave scientists an idea of how they could combine therapies, each of which have been orare beingtested in humans. This kind of approach will not make miracles, said Gregoire Courtine, the studys lead author, but its interesting because it offers new therapeutic avenues for these very traumatic injuries. First, the researchers injected the injured rats with chemicals designed to mimic the bodys own cocktail of signals that coordinate movement of the lower body. Five to 10 minutes after the injection, the researchers sent electrical impulses to tiny electrodes placed in the narrow space between the bones of the spine and the nerves of the spinal cord, stokingthe spinal cords ability to come back after an injury, a quality scientists call neuroplasticity. The findings were published today in the journal Science. After a few weeks of the combination of chemicals and electricity, 10 rats were trained to use their paralyzed hind legs with the help of … Continue reading

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