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Stem cell-derived neurotransmissions measured

Posted: Published on May 6th, 2012

In an effort to identify the underlying causes of neurological disorders that impair motor functions such as walking and breathing, UCLA researchers have developed a novel system to measure communication between stem cell-derived motor neurons and muscle cells in a Petri dish. The study provides an important proof of principle that functional motor circuits can be created outside the body using these neurons and cells and that the level of communication, or synaptic activity, between them can be accurately measured by stimulating the motor neurons with an electrode and then tracking the transfer of electrical activity into the muscle cells to which the neurons are connected. When motor neurons are stimulated, they release neurotransmitters that depolarize the membranes of muscle cells. This allows calcium and other ions to enter the cells, causing them to contract. By measuring the strength of this activity, one can get a good estimation of the overall health of motor neurons. That estimation could shed light on a variety of neurodegenerative diseases, such as spinal muscular atrophy and amyotrophic lateral sclerosis (Lou Gehrig's disease), in which communication between motor neurons and muscle cells is thought to unravel, said the study's senior author, Bennett G. Novitch, an … Continue reading →

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A single stem cell mutation triggers fibroid tumors: Mutated stem cell 'goes wild' in frenzied tumor expansion

Posted: Published on May 6th, 2012

ScienceDaily (May 4, 2012) Fibroid uterine tumors affect an estimated 15 million women in the United States, causing irregular bleeding, anemia, pain and infertility. Despite the high prevalence of the tumors, which occur in 60 percent of women by age 45, the molecular cause has been unknown. New Northwestern Medicine preclinical research has for the first time identified the molecular trigger of the tumor -- a single stem cell that develops a mutation, starts to grow uncontrollably and activates other cells to join its frenzied expansion. "It loses its way and goes wild," said Serdar Bulun, M.D., the chair of obstetrics and gynecology at Northwestern University Feinberg School of Medicine and Northwestern Memorial Hospital. "No one knew how these came about before. The stem cells make up only 1 percent of the cells in the tumor, yet they are the essential drivers of its growth." The paper is published in the journal PLoS ONE. Masanori Ono, M.D., a post-doctoral student in Bulun's lab, is the lead author. The stem cell initiating the tumor carries a mutation called MED12. Recently, mutations in the MED12 gene have been reported in the majority of uterine fibroid tissues. Once the mutation kicks off the … Continue reading →

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A single stem cell mutation triggers fibroid tumors

Posted: Published on May 6th, 2012

Public release date: 4-May-2012 [ | E-mail | Share ] Contact: Marla Paul Marla-Paul@northwestern.edu 312-503-8928 Northwestern University CHICAGO --- Fibroid uterine tumors affect an estimated 15 million women in the United States, causing irregular bleeding, anemia, pain and infertility. Despite the high prevalence of the tumors, which occur in 60 percent of women by age 45, the molecular cause has been unknown. New Northwestern Medicine preclinical research has for the first time identified the molecular trigger of the tumor --- a single stem cell that develops a mutation, starts to grow uncontrollably and activates other cells to join its frenzied expansion. "It loses its way and goes wild," said Serdar Bulun, M.D., the chair of obstetrics and gynecology at Northwestern University Feinberg School of Medicine and Northwestern Memorial Hospital. "No one knew how these came about before. The stem cells make up only 1 percent of the cells in the tumor, yet they are the essential drivers of its growth." The paper is published in the journal PLoS ONE. Masanori Ono, M.D., a post-doctoral student in Bulun's lab, is the lead author. The stem cell initiating the tumor carries a mutation called MED12. Recently, mutations in the MED12 gene have … Continue reading →

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Blondeness In Solomon Islanders Due To Genetic Variations

Posted: Published on May 6th, 2012

Excess sun exposure, a diet rich in fish, and gene inheritance from ancient explorers and traders, are all possible theories why some dark-skinned indigenous Solomon Islanders are naturally blonde, according to new research published today in the journal Science. The study, led by Stanford University researchers, found that 5 to 10 percent of the indigenous Solomon population have a gene that is responsible for blondeness. The trait, however, is distinctly different from the gene that causes blond hair in Europeans. Their findings reveal a genetic variant which has led the islanders to have simultaneously the darkest skin pigmentation outside of Africa and the highest prevalence of blonde hair outside of Europe. Previous studies have proven that pigmentation is largely genetic but also has evolved to adapt to the Suns ultraviolet rays with populations near the equator having the darkest skin and hair color. However, the native Solomon Islanders differ from this trend. This is one of the most beautiful examples to date of the mapping of a simple genetic trait in humans, David Reich, PhD, a professor of genetics at Harvard University, who was not involved in the study, said in a Stanford press release. The research, co-led by researchers … Continue reading →

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Stem cell therapy to battle HIV?

Posted: Published on May 6th, 2012

(SACRAMENTO, Calif.) -- UC Davis Health System researchers are a step closer to launching human clinical trials involving the use of an innovative stem cell therapy to fight the virus that causes AIDS. In a paper published in the May issue of the Journal of Virology, the UC Davis HIV team demonstrated both the safety and efficacy of transplanting anti-HIV stem cells into mice that represent models of infected patients. The technique, which involves replacing the immune system with stem cells engineered with a triple combination of HIV-resistant genes, proved capable of replicating a normally functioning human immune system by protecting and expanding HIV-resistant immune cells. The cells thrived and self-renewed even when challenged with an HIV viral load. "We envision this as a potential functional cure for patients infected with HIV, giving them the ability to maintain a normal immune system through genetic resistance," said lead author Joseph Anderson, an assistant adjunct professor of internal medicine and a stem cell researcher at the UC Davis Institute for Regenerative Cures. "Ideally, it would be a one-time treatment through which stem cells express HIV-resistant genes, which in turn generate an entire HIV-resistant immune system." To establish immunity in mice whose immune … Continue reading →

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Express Scripts to Present at Bank of America Merrill Lynch Conference

Posted: Published on May 4th, 2012

ST. LOUIS, May 4, 2012 /PRNewswire/ --Express Scripts, Inc. (ESRX) announced that it will present at the Bank of America Merrill Lynch 2012 Healthcare Conference on May 16, 2012 at 1:00 p.m. PDT (4:00 p.m. EDT) at the Encore at the Wynn in Las Vegas, Nevada. This presentation will also be broadcast via the Internet and can be accessed on the investor relations section of Express Scripts' web site at http://www.express-scripts.com RealPlayer or Windows Media Player is needed to listen to the Webcast and free downloads of these players are available at the Webcast sites. The Webcast will be archived and available for replay for 14 days. Express Scripts is leading the way toward creating better health and value for patients through Consumerology, the advanced application of the behavioral sciences to healthcare. This approach is helping millions of members realize greater healthcare outcomes and lowering cost by assisting in influencing their behavior. Headquartered in St. Louis, Express Scripts provides integrated pharmacy benefit management services including network-pharmacy claims processing, home delivery services, specialty benefit management, benefit-design consultation, drug-utilization review, formulary management, and medical and drug data analysis services. The company also distributes a full range of biopharmaceutical products and provides extensive … Continue reading →

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Research and Markets: Case Studies in Abnormal Psychology, 9th Edition Includes a Number of Transcripts of Therapy …

Posted: Published on May 4th, 2012

DUBLIN--(BUSINESS WIRE)-- Research and Markets (http://www.researchandmarkets.com/research/v7khhj/case_studies_in_ab) has announced the addition of John Wiley and Sons Ltd's new book "Case Studies in Abnormal Psychology, 9th Edition" to their offering. Would you like to include more high interest cases in your Abnormal Psychology course? Most textbooks on abnormal psychology include short descriptions of actual clinical cases. However, those presentations are necessarily brief and too fragmented for students to gain a clear understanding of the unique complexities of a person's troubled life. "Case Studies in Abnormal Psychology, Ninth Edition" takes mental disorders from the realm of theory into the complex reality of human lives. This casebook presents comprehensive coverage of 23 high interest cases that include topics such as eating disorders, gender identity disorder, borderline personality, and posttraumatic stress disorder. Each study (1) provides detailed descriptions of a range of clinical problems, (2) illustrates some of the ways in which these problems can be viewed and treated, and (3) discusses some of the evidence that is available concerning the prevalence and causes of the disorders in question. "Case Studies in Abnormal Psychology, Ninth Edition" is available in alternate versions (eBooks and custom) for professors and students. A NEW chapter to describing a woman … Continue reading →

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Fibrocell Science Technology Leads to Discovery of Two Rare Adult Stem Cell-Like Subpopulations in Human Skin

Posted: Published on May 4th, 2012

EXTON, Pa.--(BUSINESS WIRE)-- In collaboration with Fibrocell Science, Inc., (OTCBB:FCSC.OB), researchers at the University of California, Los Angeles (UCLA) have identified two rare adult stem cell-like subpopulations in adult human skin, a discovery that may yield further ground-breaking research in the field of personalized medicine for a broad range of diseases. Using technology developed by Fibrocell Science, Inc. the researchers were able to confirm the existence of these two types of cells in human skin cell cultures, potentially providing a source of stem cell-like subpopulations from skin biopsies, which are quicker to perform, relatively painless and less invasive than bone marrow and adipose tissue extractions, which are the current methods for deriving adult stem cells for patient-specific cellular therapies. The findings, which are reported in the inaugural issue of BioResearch Open Access, pertain to two subtypes of cells: SSEA3-expressing regeneration-associated (SERA) cells, which may play a role in the regeneration of human skin in response to injury and mesenchymal adult stem cells (MSCs), which are under investigation (by many independent researchers) for their ability to differentiate into the three main types of cells: osteoblasts (bone cells), chondrocytes (cartilage cells) and adipocytes (fat cells). Finding these specialized cells within the skin … Continue reading →

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University of Miami’s Interdisciplinary Stem Cell Institute Awarded $10 Million Grant from Starr Foundation

Posted: Published on May 4th, 2012

MIAMI--(BUSINESS WIRE)-- The University of Miami Miller School of Medicines Interdisciplinary Stem Cell Institute (ISCI) today announced that it received a $10 million grant from The Starr Foundation, one of the largest private foundations in the United States. The grant will support ISCI in broadening its preclinical and clinical research on stem cells, and help accelerate its pipeline of translational research and programs for a wide range of debilitating conditions including cardiac disease, cancer, wound healing, stroke, glaucoma and chronic kidney and gastrointestinal diseases. This is a momentous and transformative gift for the Interdisciplinary Stem Cell Institute, said Joshua M. Hare, M.D., F.A.C.C., F.A.H.A., Louis Lemberg Professor of Medicine at the University of Miami Miller School of Medicine and director of ISCI. We are so gratified that the level of science being conducted here was recognized by this very generous grant from The Starr Foundation. With this award, we join the ranks of the other major top-tier universities funded by The Starr Foundation. This support, along with our growing NIH funding, technology transfer, and other philanthropic efforts guarantees the stability of ISCI through the end of the decade, and will allow us to continue to push the boundaries of regenerative … Continue reading →

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Bio-Matrix Subsidiary “First in Class” Approach to Stem Cell Medicine

Posted: Published on May 4th, 2012

SAN DIEGO, CA--(Marketwire -05/03/12)- Regen BioPharma (Regen), Inc. a newly-formed subsidiary of Bio-Matrix Scientific Group, Inc. (BMSN.PK - News) (BMSN.PK - News), unveiled today its operational plan for its "Super-Incubator" stem cell company. Month 1-2: Assembly of Team. Regen intends to assemble a team of world-class leaders in the spheres of Technology, Intellectual Property assessment, valuation and Clinical development. Regen will seek to compile a team of Physician-Scientists with experience in the area of clinical trials for regenerative medicine/stem cell products, Regulatory experts who have successfully taken products through the FDA and corresponding agencies internationally, and Biotech Entrepreneurs who have track records of excellence in business formation and value optimization. Month 1-4: In-licensing of Intellectual Property. The Company having already assessed over 20,000 issued patents and having compiled a shortlist of 30 targets; Regen will seek to execute licensing deals on an initial core of 3 technologies. Regen focuses on issued patents that have already passed preclinical studies but are not under clinical development. Month 3-6: Interaction with Regulatory Agencies. Regen intends to develop data packages for each of the technologies and initiate interaction with Regulatory Agencies such as the FDA for initiation of trials. Month 6-18: Clinical Implementation. Regen … Continue reading →

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