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Pupils strip-searched for drugs

Posted: Published on March 12th, 2012

12 March 2012 Last updated at 16:05 ET A mother says she is outraged after her son and nine other boys were strip-searched at school on suspicion of carrying drugs in their underwear. Police arrested two pupils, aged 15 and 16, after searching the group of year 11 boys at John Port School in Etwall, Derbyshire, on 9 March. Officers had received a tip-off the pupils were sneaking the drugs into the school in their underwear. The mother, whose son was not arrested, said parents were not told in advance. She said: "He's just very distraught by it all - very embarrassed. I feel my child has been victimised. "For police to actively go into the school and physically strip-search your child without your permission or knowledge, I'm outraged as I'm sure any parent would be." Police said the operation was carried out using powers provided by the Misuse of Drugs Act. Insp Paul Cannon said: "We had very specific intelligence about how the drugs were being brought into the school and the fact they were being brought in in the children's underwear. "We have a duty to investigate criminality and, particularly with drugs, protect vulnerable people from coming into … Continue reading

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Pain Drugs Linked to Bone Death Under Review

Posted: Published on March 12th, 2012

An advisory panel for the Food and Drug Administration will weigh in today (March 12) on whether drug companies can resume trials of pain drugs for osteoarthritis. Testing of the drugs, known as anti-nerve growth factor (anti-NGF) drugs, was halted by the FDA in 2010 and early 2011 after some patients taking them experienced bone tissue death in the joints, and required joint replacements. No cases of joint tissue death were seen in patients in the studies who took a placebo. Three drugs companies Pfizer, Johnson & Johnson and Regeneron Pharmaceuticals were testing anti-NGF drugs before the trials were stopped. Pfizer's drug, tanezumab, was the farthest along in trials. Today's meeting is unusual in that the panel will be discussing drugs that are not already approved by the FDA or under review for approval, Bob Rappaport, director of the FDA's division of anesthesia, analgesia, and addiction products, said in a memo to the meeting's attendees. Anti-NGF drugs block nerve growth factor, a protein that is important for the development and survival of certain nerve cells also thought to cause sensitivity to pain in certain conditions. A 2010 study of 450 patients with knee osteoarthritis found tanezumab reduced pain by 45 … Continue reading

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FDA panel supports continued testing of pain drugs

Posted: Published on March 12th, 2012

WASHINGTON (AP) A panel of arthritis experts recommended Monday that the federal government allow continued testing of an experimental class of pain drugs for arthritis, despite links to bone decay and joint failure The Food and Drug Administration's 21-member panel of arthritis experts voted unanimously that research on the nerve-blocking drugs should continue, with certain safety precautions. Reports of joint failure led the agency to halt studies of the drugs in 2010 before any of the medications could be submitted for U.S. approval. Pfizer Inc., Johnson & Johnson and Regeneron Pharmaceuticals have asked the FDA to lift the moratorium on testing of their drugs. The FDA will weigh the advice of its panel before making a final decision. "There's clearly a worrisome safety signal, but in spite of that, I think there's an unmet need in certain patient populations," said panelist Dr. Sherine Gabriel, of the Mayo Medical School in Rochester, Minn. Panelists noted that not all patients respond to medications currently on the market, like Aleve and aspirin. The experts also said that the drugs could prove useful in treating a variety of other chronic pain conditions for which there are few options. "Anything that has the hope of … Continue reading

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LegitScript Analysis: 1 in 3 Rogue Online Pharmacies with Single Registrar

Posted: Published on March 12th, 2012

PORTLAND, Ore.--(BUSINESS WIRE)-- In the wake of news regarding counterfeit Avastin hitting the US market, a new analysis released by LegitScript.com estimates that out of roughly 450 companies with ICANN accreditations to sell domain names, over 71% of all rogue online pharmacies are clustered with just ten Registrars, with over 50% of all rogue online pharmacies at just two Registrars. The report estimates that a single Registrar, Internet.bs, sponsors 1 in 3 (33%) of the worlds active rogue online pharmacies, even though it is the Registrar for only about 0.2% of the worlds domain names overall. According to the companys report, 44% of not recommended online pharmacies listed on the National Association of Boards of Pharmacys website are registered with the company as well. The report identifies rogue online pharmacies as websites facilitating the sale of prescription drugs without requiring a prescription and/or selling unapproved (e.g., counterfeit or falsified) medicines, and notes several recent instances of death, overdose or injury from such websites. LegitScript President John Horton stated, A significant majority of Registrars should be commended for prohibiting the use of their platforms in the furtherance of counterfeit drug and other illicit drug sales. However, rogue online pharmacies are clustering … Continue reading

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Soldier Held in Afghan Massacre Had Brain Injury, Marital Problems

Posted: Published on March 12th, 2012

The Army staff sergeant who allegedly went on a rampage and killed 16 Afghans as they slept in their homes had a traumatic brain injury at one point and had problems at home after his last deployment, officials told ABC News. But the soldier, who is based at Fort Lewis in Washington, was considered fit for combat duty and deployed to Afghanistan in December, officials said. Details about the staff sergeant, who has not been identified, emerged as the Taliban vowed revenge against "sick-minded American savages" after the mass killing. What has trickled about the suspect is that he was 38, on his fourth combat deployment in 10 years, the first three in Iraq. He was on his first tour in Afghanistan, where he'd been since December. When the massacre took place he was assigned to Camp Belambay, a remote combat outpost where his job was to be protection for Special Operations Forces who were creating local militias. He was not a member of the special forces unit. An official told ABC News that the soldier has suffered a mild traumatic brain injury (TBI) in the past, either from hitting his head on the hatch of a vehicle or in … Continue reading

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Soldier in Massacre Had Brain Injury

Posted: Published on March 12th, 2012

The Army staff sergeant who allegedly went on a rampage and killed 16 Afghans as they slept in their homes had a traumatic brain injury at one point and had problems at home after his last deployment, officials told ABC News. But the soldier, who is based at Fort Lewis in Washington, was considered fit for combat duty and deployed to Afghanistan in December, officials said. Details about the staff sergeant, who has not been identified, emerged as the Taliban vowed revenge against "sick-minded American savages" after the mass killing. What has trickled out about the suspect is that he was 38 and serving on his fourth combat deployment in 10 years, the first three in Iraq. He was on his first tour in Afghanistan, where he'd been since December. When the massacre took place he was assigned to Camp Belambay, a remote combat outpost where his job was to be protection for Special Operations Forces who were creating local militias. He was not a member of the special forces unit. An official told ABC News that the soldier has suffered a mild traumatic brain injury (TBI) in the past, either from hitting his head on the hatch of a … Continue reading

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Estrogen-Only HRT May Reduce Breast Cancer Risk for Women With Hysterectomies

Posted: Published on March 12th, 2012

A new study published in Lancet Oncology states that estrogen-only hormone replacement therapy (HRT) may protect a small group of women against breast cancer. The findings of this study are in direct contradiction to multiple other studies that state estrogen can cause breast cancer. Should women consider taking estrogen to prevent breast cancer? The findings of the study indicate they should not. The study The latest edition of Lancet Oncology contains an article authored by Garnet L. Anderson Ph.D., titled "Conjugated equine oestrogen and breast cancer incidence and mortality in postmenopausal women with hysterectomy: extended follow-up of the Women's Health Initiative randomised placebo-controlled trial." The article details the results of a follow-up study done on 7,645 women, ages 50-79 years of age, who have undergone a hysterectomy and were using estrogen-only HRT for menopausal symptoms. The results of the study showed that for women with an average risk for breast cancer, the estrogen-only HRT seemed to offer protection against breast cancer when taken over an average time period of 5.9 years. The Lancet article further states that women in the same group who had a higher risk of breast cancer due to behavioral, genetic or family history did not receive … Continue reading

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Baylor, Dasa Partner to Bring Genetic Testing to Brazil

Posted: Published on March 12th, 2012

By a GenomeWeb staff reporter NEW YORK (GenomeWeb News) Baylor College of Medicine's Medical Genetics Laboratory and Brazil's Dasa medical diagnostic laboratory announced on Friday an agreement to provide advanced genetic testing technology in that country. Under the terms of the deal, Baylor's lab in Houston will conduct genetic testing and prepare a clinical report for Dasa, which will convey the results to the ordering physician in Brazil. The agreement also provides Dasa access to Baylor's database of clinical microarray results and access to Baylor's genetic research and diagnostic laboratory expertise, BCM said. Luis Franco, assistant professor of molecular and human genetics at BCM, said in a statement that the collaboration is expected to create opportunities for technology transfer and the joint development of tests tailored to the Brazilian market. Financial and other terms were not disclosed. Dasa is Latin America's largest medical reference lab and the world's fourth-largest provider of diagnostic services, according to BCM. Go here to read the rest: Baylor, Dasa Partner to Bring Genetic Testing to Brazil … Continue reading

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Correcting human mitochondrial mutations

Posted: Published on March 12th, 2012

Public release date: 12-Mar-2012 [ | E-mail | Share ] Contact: Kim Irwin kirwin@mednet.ucla.edu 310-206-2805 University of California - Los Angeles Health Sciences Researchers at the UCLA stem cell center and the departments of chemistry and biochemistry and pathology and laboratory medicine have identified, for the first time, a generic way to correct mutations in human mitochondrial DNA by targeting corrective RNAs, a finding with implications for treating a host of mitochondrial diseases. Mutations in the human mitochondrial genome are implicated in neuromuscular diseases, metabolic defects and aging. There currently are no methods to successfully repair or compensate for these mutations, said study co-senior author Dr. Michael Teitell, a professor of pathology and laboratory medicine and a researcher with the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA. Between 1,000 and 4,000 children per year in the United States are born with a mitochondrial disease and up to one in 4,000 children in the U.S. will develop a mitochondrial disease by the age of 10, according to Mito Action, a nonprofit organization supporting research into mitochondrial diseases. In adults, many diseases of aging have been associated with defects of mitochondrial function, including diabetes, Parkinson's … Continue reading

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UCLA scientists find insulin, nutrition prevent blood stem cell differentiation in fruit flies

Posted: Published on March 12th, 2012

Public release date: 11-Mar-2012 [ | E-mail | Share ] Contact: Kim Irwin kirwin@mednet.ucla.edu 310-206-2805 University of California - Los Angeles Health Sciences UCLA stem cell researchers have shown that insulin and nutrition keep blood stem cells from differentiating into mature blood cells in Drosophila, the common fruit fly, a finding that has implications for studying inflammatory response and blood development in response to dietary changes in humans. Keeping blood stem cells, or progenitor cells, from differentiating into blood cells is important as they are needed to create the blood supply for the adult fruit fly. The study found that the blood stem cells are receiving systemic signals from insulin and nutritional factors, in this case essential amino acids, that helped them to maintain their "stemness," said study senior author Utpal Banerjee, professor and chairman of the molecular, cell and developmental biology department in Life Sciences and a researcher with the Eli and Edythe Broad Center of Regenerative Medicine at UCLA. "We expect that this study will promote further investigation of possible direct signal sensing mechanisms by mammalian blood stem cells," Banerjee said. "Such studies will probably yield insights into chronic inflammation and the myeloid cell accumulation seen in patients … Continue reading

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