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Influencing stem cell fate: New screening method helps scientists identify key information rapidly

Posted: Published on March 7th, 2012

ScienceDaily (Mar. 6, 2012) Northwestern University scientists have developed a powerful analytical method that they have used to direct stem cell differentiation. Out of millions of possibilities, they rapidly identified the chemical and physical structures that can cue stem cells to become osteocytes, cells found in mature bone. Researchers can use the method, called nanocombinatorics, to build enormous libraries of physical structures varying in size from a few nanometers to many micrometers for addressing problems within and outside biology. Those in the fields of chemistry, materials engineering and nanotechnology could use this invaluable tool to assess which chemical and physical structures -- including size, shape and composition -- work best for a desired process or function. Nanocombinatorics holds promise for screening catalysts for energy conversion, understanding properties conferred by nanostructures, identifying active molecules for drug discovery or even optimizing materials for tissue regeneration, among other applications. Details of the method and proof of concept is published in the Proceedings of the National Academy of Sciences. "With further development, researchers might be able to use this approach to prepare cells of any lineage on command," said Chad A. Mirkin, who led the work. "Insight into such a process is important for … Continue reading

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International Stem Cell Corporation to Present at the Roth Conference on March 14

Posted: Published on March 7th, 2012

CARLSBAD, Calif.--(BUSINESS WIRE)-- International Stem Cell Corporation (OTCBB:ISCO.OB - News) today announced that Co-Chairman Kenneth Aldrich and President and Chief Operating Officer Kurt May will be presenting at the 24th Annual Roth Conference on Wednesday, March 14, 2012 at 1:00 p.m. Pacific time. The conference is being held March 11-14 at the Ritz Carlton Hotel in Dana Point, California. About International Stem Cell Corporation International Stem Cell Corporation is focused on the therapeutic applications of human parthenogenetic stem cells (hpSCs) and the development and commercialization of cell-based research and cosmetic products. ISCO's core technology, parthenogenesis, results in the creation of pluripotent human stem cells from unfertilized oocytes (eggs). hpSCs avoid ethical issues associated with the use or destruction of viable human embryos. ISCO scientists have created the first parthenogenic, homozygous stem cell line that can be a source of therapeutic cells for hundreds of millions of individuals of differing genders, ages and racial background with minimal immune rejection after transplantation. hpSCs offer the potential to create the first true stem cell bank, UniStemCell. ISCO also produces and markets specialized cells and growth media for therapeutic research worldwide through its subsidiary Lifeline Cell Technology, and cell-based skin care products through its … Continue reading

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New approach for treating genetic muscle wasting disease shows promise in mice

Posted: Published on March 7th, 2012

Public release date: 6-Mar-2012 [ | E-mail | Share ] Contact: Jennifer Ganton jganton@ohri.ca 613-798-5555 x73325 Ottawa Hospital Research Institute Scientists from the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa (uOttawa) have discovered that a drug called fasudil can extend the average lifespan of mice with Spinal muscular atrophy (SMA) from 30.5 days to more than 300 days. The study is published today in BioMed Central's open access journal BMC Medicine, by Dr. Rashmi Kothary, his graduate student Melissa Bowerman and others. SMA is the leading inherited cause of death in infants and toddlers, affecting approximately 25,000 people in Canada and the United States. Scientists have known for many years that this disease is caused by inherited mutations in a gene called survival motor neuron 1 (SMN1). Most early attempts at developing treatments for SMA focused on replacing this gene, however, Dr. Kothary's group has focused on understanding and targeting the physiological defects present in certain nerve cells with SMA. These cells have a weakened internal scaffold, which hinders their ability to connect with muscle cells and contributes to the severe muscle weakness associated with SMA. Two years ago, Dr. Kothary and his team showed that a … Continue reading

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Fourteenth Patient Dosed in Neuralstem ALS Stem Cell Trial

Posted: Published on March 7th, 2012

ROCKVILLE, Md., March 7, 2012 /PRNewswire/ -- Neuralstem, Inc. (NYSE Amex: CUR) announced that the second patient to receive stem cells in the cervical (upper back) region of the spine was dosed on February 29th in the ongoing Phase I trial of its spinal cord neural stem cells in amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease). Patient 14 is also the first woman to be treated in the trial. Stem cell transplantation into the cervical region of the spinal cord couldsupport breathing, a key function that is lost as ALS progresses. The first twelve patients in the trial received stem cell transplants in the lumbar (lower back) region of the spinal cord only. (Logo: http://photos.prnewswire.com/prnh/20061221/DCTH007LOGO ) "This cohort of patients represents another first for our trial, as we transplant cells directly into the gray matter of the spinal cord in the cervical region," said Karl Johe, PhD, Neuralstem's Chairman and Chief Scientific Officer. "We are delighted that the surgeries are progressing in a region that could have a significant impact on the quality of life for ALS patients. With the safe transplantation of our 14th patient, we are well are on our way to demonstrating the safety of our … Continue reading

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Arrowhead Releases White Paper on Hepatitis B Virus and Potential RNAi Treatment

Posted: Published on March 7th, 2012

PASADENA, Calif.--(BUSINESS WIRE)-- Arrowhead Research Corporation (NASDAQ: ARWR - News), a nanomedicine company with development programs in RNA therapeutics and obesity, announced today that it has released a white paper describing the health problem posed by the hepatitis B virus (HBV), the substantial unmet need for chronic HBV infected patients, and how Arrowheads Dynamic Polyconjugate (DPC) enabled RNAi therapeutic in development could potentially address deficiencies of current treatment options. Hepatitis B is a global health problem without effective treatment for a vast number of patients with chronic disease. The World Health Organization estimates that 360 million people, or 5% of the worlds population, suffer from chronic hepatitis B, said Christopher Anzalone, Ph.D., President and CEO of Arrowhead. Advances in hepatitis C treatment have drawn considerable attention over the last year, and we see HBV as a similarly high value target. Extensive data from our development programs across multiple in vitro and animal models suggest that we can leverage RNAi and our DPCs to produce a powerful and highly specific candidate to fight HBV. HBV infection occurs primarily in hepatocytes and long-term infection causes hepatic inflammation that leads to acute and chronic hepatic dysfunction including acute hepatic failure, cirrhosis, and hepatocellular … Continue reading

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Heart drug 'could tackle racism'

Posted: Published on March 7th, 2012

A common heart disease drug may have the unusual side effect of combating racism, a new study suggests. Volunteers given the beta-blocker, used to treat chest pains and lower heart rates, scored lower on a standard psychological test of "implicit" racist attitudes. They appeared to be less racially prejudiced at a subconscious level than another group treated with a "dummy" placebo pill. Scientists believe the discovery can be explained by the fact that racism is fundamentally founded on fear. Propranolol acts both on nerve circuits that govern automatic functions such as heart rate and the part of the brain involved in fear and emotional responses. The drug is also used to treat anxiety and panic. Experimental psychologist Dr Sylvia Terbeck, from Oxford University, who led the study published in the journal Psychopharmacology, said: "Our results offer new evidence about the processes in the brain that shape implicit racial bias. "Implicit racial bias can occur even in people with a sincere belief in equality. Given the key role that such implicit attitudes appear to play in discrimination against other ethnic groups, and the widespread use of propranolol for medical purposes, our findings are also of considerable ethical interest." Two groups of … Continue reading

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First Pradaxa Side Effects Lawsuits Filed By Watts Guerra Craft LLP

Posted: Published on March 7th, 2012

The product liability and dangerous drug lawyers of Watts Guerra Craft LLP have filed the first three federal Pradaxa injury and death cases in the country. Mikal C. Watts and Ryan L. Thompson are proud to handle what is believed to be the largest Pradaxa injury and wrongful death docket in the United States. San Antonio, TX (PRWEB) March 06, 2012 Watts, known internationally for his handling of vehicle rollover cases and the BP Multidistrict Litigation (MDL No. 2179), and his Pradaxa team of nearly 60 dedicated pharmaceutical defect staff members, all led by Thompson, are closely watching the ongoing U.S. Food and Drug Administration (FDA) investigation into Pradaxa and its potentially deadly side effects. The FDA is now investigating post-marketing reports of serious bleeding events and deaths in patients taking Pradaxa (dabigatran etexilate). Pradaxa was approved in October 2010 by the FDA for the prevention of stroke in patients with non-valvular atrial fibrillation. Atrial fibrillation is the most common heart rhythm condition in the world. Patients with this condition typically require blood-thinning medications such as the well-known warfarin. Pradaxa was the first alternative to warfarin approved in nearly 60 years. Problems were quick to follow. In November 2011, Boehringer … Continue reading

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The Law Firm of Alonso Krangle LLP Now Evaluating Actos Lawsuit Claims on Behalf of Victims of Actos Bladder Cancer …

Posted: Published on March 7th, 2012

Alonso Krangle LLP is now evaluating lawsuits on behalf of Actos side effect victims who have been diagnosed with bladder cancer that may be related to their use of Actos. The U.S. Food & Drug Administration (FDA) warned last year that use of Actos may increase the risk of bladder cancer in people who use the type 2 diabetes medication for more than one year. Melville, NY (PRWEB) March 06, 2012 Actos Lawsuit Claims and What to Do Alonso Krangle LLP is now offering free Actos lawsuit evaluations to anyone who believes they developed bladder cancer side effects because of Actos or a related drug, including Actoplus Met, Actoplus Met XR and Duetact. To discuss a potential Actos bladder cancer lawsuit claim with one of the experienced and compassionate Actos lawyers at Alonso Krangle LLP, please contact us at 1-800-403-6191 or visit our website, http://www.FightForVictims.com. Actos Bladder Cancer Side Effects Actos, known generically as pioglitazone, is an oral diabetes medication marketed by Takeda Pharmaceuticals. Actos was approved by the U.S. Food & Drug Administration (FDA) in 1999, and has since become the best-selling type 2 diabetes medications in the world. [bloomberg.com/news/2011-12-31/takeda-suits-on-actos-diabetes-drug-combined-in-one-louisiana-court.html]. Pioglitazone, the active ingredient in Actos is also sold … Continue reading

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'Gaseous' aspirin could be potent anti-cancer drug

Posted: Published on March 7th, 2012

London, Mar 7 (ANI): Scientists including two of Indian origin have developed a hybrid aspirin that has much better cancer-fighting ability than either of its forebears and might even reduce the harmful side effects of taking aspirin daily. The new form is named NOSH-aspirin, as it releases nitric oxide (NO) and hydrogen sulfide (H2S). Khosrow Kashfi, Ravinder Kodela and Mitali Chattopadhyay point out that NO and H2S are signalling substances produced in the body that relax blood vessels, reduce inflammation and have a variety of other effects. Scientists previously developed designer aspirin that releases NO in an effort to reduce aspirin's potential adverse effects in causing bleeding in the gastrointestinal tract. Another designer aspirin that releases H2S was developed which also has anti-inflammatory properties and appears safe to the stomach. Since NO and H2S are gases with physiological relevance, and Kashfi's group had previously shown beneficial effects with both NO- and H2S-aspirins, they postulated that a new hybrid that incorporated both of these entities might be even more potent and effective than either one alone. Their hypothesis has proved to be correct. They found indications that the new hybrid inhibits the growth of breast, colon, pancreas, lung, prostate and some … Continue reading

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Once-a-month HIV drug maintains good levels for prevention; few side-effects so far

Posted: Published on March 7th, 2012

The first trial in humans of an injectable, once-a-month formulation of an HIV drug has found that drug levels were maintained at a level that should in theory be high enough to protect recipients against infection, and that the drug has so far produced very few side effects. The research was presented at the 19th Conference on Opportunistic Infections (CROI), in Seattle. The small trial at the St Stephens AIDS Trust (SSAT) at Londons Chelsea and Westminster Hospital gave 27 women and six men a single injection of the long-acting formulation of the drug rilpivirine, which was licensed as an oral HIV treatment last year as Edurant and is also in the tenofovir/FTC/rilpivirine pill Complera. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) drug and is especially suitable to be turned into a long-lasting injectable form because the daily dose of it required to suppress HIV is very small. No other HIV drugs are currently in a usable long-lasting injectable form, which will limit the use of long-acting rilpivirine (RPV-LA) in combination therapy, but it could conceivably make an ideal candidate as a prevention drug, as people would not need to remember to take it every day. Other preventative drugs … Continue reading

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