The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension – Science

Masato Morikawa

Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, SE-751 23 Uppsala, Sweden.Ludwig Institute for Cancer Research, Science for Life Laboratory, Box 595, Biomedical Center, Uppsala University, SE-751 24 Uppsala, Sweden.

Yoshihide Mitani

Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.

Katarina Holmborn

Genome Engineering Zebrafish Facility, Science For Life Laboratory, Uppsala University, SE-752 36 Uppsala, Sweden.

Taichi Kato

Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.

Daizo Koinuma

Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

Junko Maruyama

Department of Anesthesiology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.

Eleftheria Vasilaki

Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, SE-751 23 Uppsala, Sweden.Ludwig Institute for Cancer Research, Science for Life Laboratory, Box 595, Biomedical Center, Uppsala University, SE-751 24 Uppsala, Sweden.

Hirofumi Sawada

Department of Pediatrics, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.Department of Anesthesiology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.

Mai Kobayashi

Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

Takayuki Ozawa

Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

Yasuyuki Morishita

Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

Yasumasa Bessho

Institute for Frontier Life and Medical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.

Shingo Maeda

Department of Medical Joint Materials, Kagoshima University, Kagoshima, Kagoshima 890-8544, Japan.

Johan Ledin

Genome Engineering Zebrafish Facility, Science For Life Laboratory, Uppsala University, SE-752 36 Uppsala, Sweden.

Hiroyuki Aburatani

Genome Science Division, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Meguro-ku, Tokyo 153-8904, Japan.

Ryoichiro Kageyama

Institute for Frontier Life and Medical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.

Kazuo Maruyama

Department of Anesthesiology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.

Carl-Henrik Heldin

Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, SE-751 23 Uppsala, Sweden.Ludwig Institute for Cancer Research, Science for Life Laboratory, Box 595, Biomedical Center, Uppsala University, SE-751 24 Uppsala, Sweden.

Kohei Miyazono

Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Box 582, Biomedical Center, Uppsala University, SE-751 23 Uppsala, Sweden.Ludwig Institute for Cancer Research, Science for Life Laboratory, Box 595, Biomedical Center, Uppsala University, SE-751 24 Uppsala, Sweden.

Originally posted here:

The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension - Science