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Stem Cell Therapy Selectively Targets and Kills Cancerous Tissue – Anti Aging News

Posted: Published on August 12th, 2017

Researchers have created a method to kill cancerous tissue without causing the harmful side effects of chemotherapy. Medical researchers at the University of California, Irvine have created a stem cell-based method to zero in on cancerous tissue. This method kills the cancerous tissue without causing the nasty side effects of chemotherapy. Such side effects are avoided by treating the disease in a more localized manner. The advancement was spearheaded by associate professor of pharmaceutical sciences Weian Zhao. The details of the stem cell therapy were recently published in Science Translational Medicine. About the new Stem Cell Therapy Zhao's team programmed stem cells derived from human bone marrow to pinpoint the specific properties of cancerous tissue. They implemented a portion of code to these engineered cells to identify stiff cancerous tissue, lock onto it and implement therapeutics. The researchers safely used this new stem cell therapy in mice to kill metastatic breast cancer that had moved to the lungs. They transplanted these engineered stem cells in order for the teamto pinpoint and settle in the site of the tumor. Once the stem cells reached the tumor, they released enzymes referred to as cytosine deaminase. The mice were then provided with an … Continue reading

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Mutation-directed CAR T cell therapy feasible in recurrent glioblastoma – medwireNews

Posted: Published on August 12th, 2017

medwireNews: Treatment with autologous chimeric antigen receptor (CAR) T cells directed against the epidermal growth factor receptor variant III (EGFRvIII) mutation is feasible and well tolerated in patients with recurrent glioblastoma, indicates a first-in-human study. But barriers to the clinical efficacy of the therapy exist, says the research team, including the inhibitory tumor microenvironment, which becomes even more immunosuppressive after CAR T cells. Lead author Marcela Maus (Massachusetts General Hospital, Boston, USA) and colleagues chose the EGFRvIII mutation as it is a tumor-specific, oncogenic, and immunogenic epitope expressed in around 30% of newly diagnosed cases of glioblastoma. In this phase I study, reported in Science Translational Medicine, 10 patients with EGFRvIII-expressing glioblastoma that had progressed after at least one prior line of therapy were given a single infusion of an autologous EGFRvIII-directed CAR T product within a week of progression. There were no dose-limiting toxicities, and no evidence of off-target EGFR-directed effects such as rash, diarrhea, or pulmonary symptoms or systemic cytokine release syndrome. Neurologic events were observed in three patients and included a seizure at day 9 in one patient and neurologic decline in two patients, at day 15 in one case and postoperatively in the other. Although such … Continue reading

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India’s Advancells Reports Successful Reversal of MS in Single Patient Using Stem Cell Therapy – Multiple Sclerosis News Today

Posted: Published on August 12th, 2017

Advancellssays its stem cell-based therapy completely reversed multiple sclerosis (MS) in an Indian pilot trial with only one MS patient. The patient, Rahul Gupta, was diagnosed with MS seven years ago and has since suffered multiple relapses. His disease was progressing fast and he was quickly losing his ability to walk. Gupta, who lives in New Zealand, approached Advancells a company based in the Indian state of Uttar Pradesh that specializes in the use of stem cells for therapeutic purposes. After my last relapse, I became determined to look for alternative treatments for multiple sclerosis,Gupta said in a press release. I started looking on the net and found that stem-cell therapy [offers] hope for people suffering with MS [and] that it is safe and would not harm me in any way. I was determined to undergo stem-cell treatment, as my illness was progressing very quickly. Gupta enrolled inAdvancells adult stem-cell therapy program as the trials single patient. In the procedure carried outin June at a New Delhi clinic doctors isolated stem cells from his bone marrow and re-infused them back into the patientat specific points. Apart from this procedure, Gupta underwent only physiotherapy and a dietary routine. Straight after the … Continue reading

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The Impossible Burger wouldn’t be possible without genetic engineering – Grist

Posted: Published on August 12th, 2017

The Impossible Burger has had a charmed honeymoon period. Crowds of foodies surged into fancy eateries to try it. Environmentalists and animal rights activists swooned. So did investors: Impossible Foods brought in $75 million during its latest investment round. Now the backlash is here. The activist organizations Friends of the Earth and the ETC Group dug up documents which they claim show that Impossible Foods ignored FDA warnings about safety and they handed them over to the New York Times. The ensuing story depicted Impossible Foods as a culinary version of Uber disrupting so rapidly that its running headlong into government regulators. In reality, Impossible Foods has behaved like a pedestrian food company, working hand in hand with the FDA and following a well-worn path to comply with an arcane set of rules. So why isnt this story a nothingburger? In a word: GMOs. You see, soy leghemoglobin, or SLH, the key ingredient that makes the Impossible Burger uniquely meaty, is churned out by genetically modified yeast. This is a protein produced with genetic engineering; its a new food ingredient, Dana Perls, senior food and technology campaigner at Friends of the Earth, told me when I asked why theyd singled … Continue reading

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Human Germline Genome Editing Genetics bodies weigh in on debate with position paper – JD Supra (press release)

Posted: Published on August 12th, 2017

In an article published in American Journal of Human Genetics on 3 August 2017, an international group of 11 organisations with genetics expertise has issued a joint position statement, setting out 3 key positions on the question of human germline genome editing: (1)At this time, given the nature and number of unanswered scientific, ethical, and policy questions, it is inappropriate to perform germline gene editing that culminates in human pregnancy. (2)Currently, there is no reason to prohibit in vitro germline genome editing on human embryos and gametes, with appropriate oversight and consent from donors, to facilitate research on the possible future clinical applications of gene editing. There should be no prohibition on making public funds available to support this research. (3)Future clinical application of human germline genome editing should not proceed unless, at a minimum, there is (a) a compelling medical rationale, (b) an evidence base that supports its clinical use, (c) an ethical justification, and (d) a transparent public process to solicit and incorporate stakeholder input. This serendipitously timed statement comes on the heels of Shoukhrat Mitalipov and colleagues at Oregon Health and Science Universitys publication of an article in Nature reporting the successful use of CRISPR/Cas9 in human … Continue reading

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Kyle Miller: Golfer with cerebral palsy plays PGA Tour-sanctioned event – CNN

Posted: Published on August 11th, 2017

Should he win the USPGA Championship at the North Carolina course, the 24-year-old will become the youngest man in history to complete the career grand slam. More than 2,000 miles north, just across the Canadian border, fewer TV cameras and spectators are at the Country Hills Golf Club, Calgary -- but PGA Tour history has already been made nonetheless. When Kyle Miller took to the first tee of the ATB Financial Classic on Thursday, he became the first person diagnosed with cerebral palsy to play in a PGA Tour-sanctioned event. Thanks to a sponsors' exemption, which has been earned through years of hard work, charity fundraising and sheer determination, Miller has realized a lifelong dream -- and one that he was told not to reach for. "It's amazing," a delighted Miller told CNN. "You know when you see your name on the PGA Tour app or the PGA Tour website and you're reading the storylines ... you realize your dreams are coming true." "And how many times I've read through those articles or looked at those tee times and seen guys that I knew. "I've been able to teach and inspire countless people with disabilities that achieving your dream is … Continue reading

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Battling cerebral palsy, Boyd finds his drive at the gym (VIDEO) – Sentinel & Enterprise

Posted: Published on August 11th, 2017

Despite having cerebral palsy, Dwayne Boyd decided he wanted to start going to the gym for the first time at the age of 46 and began working out at Planet Fitness in Leominster. SENTINEL & ENTERPRISE/JOHN LOVE LEOMINSTER -- One of the first things you notice about Dwayne Boyd is his handshake: a bone-cracking grip not unlike the animated hand of a stone statue. Another thing you will notice are the crutches those vice-like hands are clasped to. "What people don't know is that I'm actually quadriplegic. My arms aren't affected as badly, but they are," he said. Of Leominster's roughly 40,000 residents, Boyd has one of the best excuses not to go to the gym. Diagnosed with cerebral palsy when he was just 6 months old, Boyd relies on his crutches to get around and also experiences limited mobility in his arms. He decided to join Leominster's Planet Fitness in 2015, at the age of 44. Dwayne Boyd began going to the gym for the first time at the age of 44. Despite having cerebral palsy, Boyd is a regular at Planet Fitness in Leominster. SENTINEL & ENTERPRISE PHOTO/JOHN LOVE Although he had lifted weights in high school and … Continue reading

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New York Hospital Offers Adaptive Surfing for Patients with Cerebral Palsy – Cerebral Palsy News Today

Posted: Published on August 11th, 2017

New York CitysHospital for Special Surgery (HSS)is offering a trip to Long Island for young patients with disabilities including cerebral palsy (CP) to try adaptive surfing, a practice gaining attention for its therapeutic benefits. The trip isorganized by the Adaptive Sports Academy atHSS and includes people with CP, patients who have had amputations, and others with physical challenges. Activities like adaptive surfing have been shown to help pediatric patients build self-confidence and independence, and increase physical fitness and mobility. The Adaptive Sports Academy gives our patients a chance to develop new skills and interests, and it promotes mobility and activity. It also reinforces therapy goals by engaging participants in a new activity and requiring them to use their bodies in a new way, Lisa Ipp, chief of pediatric medicine atHSS, said in apress release. There is also an emotional component. Patients are so excited about what they can achieve, and parents are so thrilled to watch them. The outings have also cultivated connections between families who stay in contact long after the event ends, Ipp added. The first trip is scheduled for Monday, Aug. 14, from 1:30 p.m. to 3:30 p.m. at Long Beach, Long Island. Trained volunteers from Skudin … Continue reading

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Calgary’s Kyle Miller makes history as first golfer with cerebral palsy … – CBC.ca

Posted: Published on August 11th, 2017

A Calgary man is becomingthe first golfer with cerebral palsy to compete at a PGA Tour-sanctioned event, theATB Financial Classic in his home city. "I have a pretty bad left side in a sense, mobility range is limited with my hand and leg," Kyle Miller told The Homestretch this week. "I just have worked through the battle and keep playing golf and caddying. It's part of the program." The 26-year-old, who is also a golf coach, says it was the support and guidance of one of his own coaches that gave him a foundation of confidence. "I was fortunate enough to have a coach Marty Desmaraiswhen I was younghelp me along the way to start learning the game at a pretty young age and I just stuck with it," he said. "Marty just gave me the belief and hope that I could do it. Ultimately, I think that's the number one thing he has given. He is probably the first person to ever believe in me in that sense." Miller says he's always been determined to work past his medical condition. "I have always wanted to earn things as straight up as it was going to get," he explained. "I … Continue reading

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Charity that supports Glaswegians with cerebral palsy awarded over 11000 – Glasgow Live

Posted: Published on August 11th, 2017

Community project Bobath Scotland Cerebral Palsy Centre in Glasgow has been awarded a 11,770 grant from the Scottish Children's Lottery. Bobath Scotland offers advice, help and support to children and adults living with cerebral palsy, and their families. Specialist therapy focuses on reducing pain, developing communication and mobility so children and adults with cerebral palsy can make the most of their own abilities and everyday life. Video Unavailable Click to playTap to play Play now Parents, siblings, teachers, local therapists and others learn how best to support and include each person. Bobath Scotland supports anyone with a diagnosis of CP, regardless of their age or location, and endeavours to reach as many people as possible at their specialist centre in Glasgow, online, and in their own communities. Stephanie Fraser , CEO of Bobath Scotland Cerebral Palsy Centre, said: Bobath Scotland is committed to helping everyone with cerebral palsy in Scotland live their lives to the full. "This wonderful donation from The Scottish Childrens Lottery will enable young people with CP to take advantage of opportunities and the desire for a fulfilled, independent, adult life that their peers take for granted. Thank you. Your support changes lives. "Chance to Connect supports … Continue reading

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