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SHEBOYGAN Fire Fighters Support MDA with Annual Fill the Boot Drive – WHBL Sheboygan

Posted: August 15, 2017 at 1:43 pm

Tuesday, August 15, 2017 8:13 a.m. CDT by Jon DeMaster

SHEBOYGAN, Wis. (WHBL) – The Sheboygan Fire Department Local 483 is showing its support for the Muscular Dystrophy Association as its members kick off the annual Fill the Boot fundraising campaign to help kids and adults with muscular dystrophy, ALS and related muscle-debilitating diseases live longer and grow stronger. It will take place August 17th and 18th.

Continuing a more than 60 year tradition, twenty dedicated fire fighters from Sheboygan Fire Department Local 483 will hit the streets with boots in hand asking pedestrians, motorists, customers and other passersby to make a donation to MDA, they will be at the intersection of 25th and Superior and 8th Street and Erie between 11am 5:00pm both days.

We are thrilled to be working with the Sheboygan Fire Department Local 483 for another year of Fill the Boot to help provide the funds needed to find treatments and cures for muscular dystrophy, ALS and related diseases that severely limit strength and mobility, said Fundraising Coordinator Murphy Maes. The dedication of these fire fighters to MDAs mission is unwavering, spending countless hours both with Fill the Boot and MDA Summer Camp to care for the kids and adults in Sheboygan. We know that their devotion to our families will make this years drive a success.

Funds raised through Sheboygan Fill the Boot events in 2017 empower families who inspire everyday Americans to help kids and adults with Muscular dystrophy and related muscle-debilitating diseases live longer and grow stronger, displaying how we all can truly live unlimited no matter what limits we may face.

Contributions also help fund groundbreaking research and life-enhancing programs such as state-of-the-art support groups and Care Centers, including the MDA Care Center at Prevea Health in Green Bay, WI and the Marshfield Clinic in Marshfield, WI. They also help send more than 45 local kids to the best week of the year at MDA summer camp at Pilgrim Center all at no cost to their families.

In addition to Fill the Boot drives, fire fighter contributions from year-round local events, including help support MDAs efforts to raise awareness and provide professional and public education about neuromuscular diseases.

As MDAs largest national partner, the IAFF fuels MDA’s mission to find research breakthroughs across diseases; care for kids and adults from day one; and provide families with services and support.

IAFF support for MDA began in 1954 when the organization committed by proclamation to support MDA until a cure is found, and the organization’s unwavering commitment to MDA has remained strong to this day. The IAFF raised $100,000 for MDA in 1955, and $1 million in 1970, and fire fighters continue to raise the bar in their fundraising efforts. In 2016, more than 100,000 fire fighters participated in Fill the Boot events across the country and raised $25 million. To date the IAFF has raised $585.5 million for MDA.

About the IAFF: The International Association of Fire Fighters represents more than 300,000 professional fire fighters and paramedics who protect 85 percent of the nations population. More than 3,200 affiliates and their members protect communities in every state in the United States and in Canada.

About MDA MDA is leading the fight to free individuals and the families who love them from the harm of muscular dystrophy, ALS and related muscle-debilitating diseases that take away physical strength, independence and life.We use our collective strength to help kids and adults live longer and grow stronger by finding research breakthroughs across diseases; caring for individuals from day one; and empowering families with services and support in hometowns across America.

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Cardiac stem cells rejuvenate rats’ aging hearts, study says – CNN – CNN

Posted: at 1:42 pm

The old rats appeared newly invigorated after receiving their injections. As hoped, the cardiac stem cells improved heart function yet also provided additional benefits. The rats’ fur fur, shaved for surgery, grew back more quickly than expected, and their chromosomal telomeres, which commonly shrink with age, lengthened.

The old rats receiving the cardiac stem cells also had increased stamina overall, exercising more than before the infusion.

“It’s extremely exciting,” said Dr. Eduardo Marbn, primary investigator on the research and director of the Cedars-Sinai Heart Institute. Witnessing “the systemic rejuvenating effects,” he said, “it’s kind of like an unexpected fountain of youth.”

“We’ve been studying new forms of cell therapy for the heart for some 12 years now,” Marbn said.

Some of this research has focused on cardiosphere-derived cells.

“They’re progenitor cells from the heart itself,” Marbn said. Progenitor cells are generated from stem cells and share some, but not all, of the same properties. For instance, they can differentiate into more than one kind of cell like stem cells, but unlike stem cells, progenitor cells cannot divide and reproduce indefinitely.

Since heart failure with preserved ejection fraction is similar to aging, Marbn decided to experiment on old rats, ones that suffered from a type of heart problem “that’s very typical of what we find in older human beings: The heart’s stiff, and it doesn’t relax right, and it causes fluid to back up some,” Marbn explained.

He and his team injected cardiosphere-derived cells from newborn rats into the hearts of 22-month-old rats — that’s elderly for a rat. Similar old rats received a placebo injection of saline solution. Then, Marbn and his team compared both groups to young rats that were 4 months old. After a month, they compared the rats again.

Even though the cells were injected into the heart, their effects were noticeable throughout the body, Marbn said

“The animals could exercise further than they could before by about 20%, and one of the most striking things, especially for me (because I’m kind of losing my hair) the animals … regrew their fur a lot better after they’d gotten cells” compared with the placebo rats, Marbn said.

The rats that received cardiosphere-derived cells also experienced improved heart function and showed longer heart cell telomeres.

Why did it work?

The working hypothesis is that the cells secrete exosomes, tiny vesicles that “contain a lot of nucleic acids, things like RNA, that can change patterns of the way the tissue responds to injury and the way genes are expressed in the tissue,” Marbn said.

It is the exosomes that act on the heart and make it better as well as mediating long-distance effects on exercise capacity and hair regrowth, he explained.

Looking to the future, Marbn said he’s begun to explore delivering the cardiac stem cells intravenously in a simple infusion — instead of injecting them directly into the heart, which would be a complex procedure for a human patient — and seeing whether the same beneficial effects occur.

Dr. Gary Gerstenblith, a professor of medicine in the cardiology division of Johns Hopkins Medicine, said the new study is “very comprehensive.”

“Striking benefits are demonstrated not only from a cardiac perspective but across multiple organ systems,” said Gerstenblith, who did not contribute to the new research. “The results suggest that stem cell therapies should be studied as an additional therapeutic option in the treatment of cardiac and other diseases common in the elderly.”

Todd Herron, director of the University of Michigan Frankel Cardiovascular Center’s Cardiovascular Regeneration Core Laboratory, said Marbn, with his previous work with cardiac stem cells, has “led the field in this area.”

“The novelty of this bit of work is, they started to look at more precise molecular mechanisms to explain the phenomenon they’ve seen in the past,” said Herron, who played no role in the new research.

One strength of the approach here is that the researchers have taken cells “from the organ that they want to rejuvenate, so that makes it likely that the cells stay there in that tissue,” Herron said.

He believes that more extensive study, beginning with larger animals and including long-term followup, is needed before this technique could be used in humans.

“We need to make sure there’s no harm being done,” Herron said, adding that extending the lifetime and improving quality of life amounts to “a tradeoff between the potential risk and the potential good that can be done.”

Capicor hasn’t announced any plans to do studies in aging, but the possibility exists.

After all, the cells have been proven “completely safe” in “over 100 human patients,” so it would be possible to fast-track them into the clinic, Marbn explained: “I can’t tell you that there are any plans to do that, but it could easily be done from a safety viewpoint.”

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UCLA scientists identify a new way to activate stem cells to make hair grow – UCLA Newsroom

Posted: at 1:42 pm

UCLA researchers have discovered a new way to activate the stem cells in the hair follicle to make hair grow. The research, led by scientists Heather Christofk and William Lowry, may lead to new drugs that could promote hair growth for people with baldness or alopecia, which is hair loss associated with such factors as hormonal imbalance, stress, aging or chemotherapy treatment.

The research was published in the journal Nature Cell Biology.

Hair follicle stem cells are long-lived cells in the hair follicle; they are present in the skin and produce hair throughout a persons lifetime. They are quiescent, meaning they are normally inactive, but they quickly activate during a new hair cycle, which is when new hair growth occurs. The quiescence of hair follicle stem cells is regulated by many factors. In certain cases they fail to activate, which is what causes hair loss.

In this study, Christofk and Lowry, of Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, found that hair follicle stem cell metabolism is different from other cells of the skin. Cellular metabolism involves the breakdown of the nutrients needed for cells to divide, make energy and respond to their environment. The process of metabolism uses enzymes that alter these nutrients to produce metabolites. As hair follicle stem cells consume the nutrient glucose a form of sugar from the bloodstream, they process the glucose to eventually produce a metabolite called pyruvate. The cells then can either send pyruvate to their mitochondria the part of the cell that creates energy or can convert pyruvate into another metabolite called lactate.

Our observations about hair follicle stem cell metabolism prompted us to examine whether genetically diminishing the entry of pyruvate into the mitochondria would force hair follicle stem cells to make more lactate, and if that would activate the cells and grow hair more quickly, said Christofk, an associate professor of biological chemistry and molecular and medical pharmacology.

The research team first blocked the production of lactate genetically in mice and showed that this prevented hair follicle stem cell activation. Conversely, in collaboration with the Rutter lab at University of Utah, they increased lactate production genetically in the mice and this accelerated hair follicle stem cell activation, increasing the hair cycle.

Before this, no one knew that increasing or decreasing the lactate would have an effect on hair follicle stem cells, said Lowry, a professor of molecular, cell and developmental biology. Once we saw how altering lactate production in the mice influenced hair growth, it led us to look for potential drugs that could be applied to the skin and have the same effect.

The team identified two drugs that, when applied to the skin of mice, influenced hair follicle stem cells in distinct ways to promote lactate production. The first drug, called RCGD423, activates a cellular signaling pathway called JAK-Stat, which transmits information from outside the cell to the nucleus of the cell. The research showed that JAK-Stat activation leads to the increased production of lactate and this in turn drives hair follicle stem cell activation and quicker hair growth. The other drug, called UK5099, blocks pyruvate from entering the mitochondria, which forces the production of lactate in the hair follicle stem cells and accelerates hair growth in mice.

Through this study, we gained a lot of interesting insight into new ways to activate stem cells, said Aimee Flores, a predoctoral trainee in Lowrys lab and first author of the study. The idea of using drugs to stimulate hair growth through hair follicle stem cells is very promising given how many millions of people, both men and women, deal with hair loss. I think weve only just begun to understand the critical role metabolism plays in hair growth and stem cells in general; Im looking forward to the potential application of these new findings for hair loss and beyond.

The use of RCGD423 to promote hair growth is covered by a provisional patent application filed by the UCLA Technology Development Group on behalf of UC Regents. The use of UK5099 to promote hair growth is covered by a separate provisional patent filed by the UCLA Technology Development Group on behalf of UC Regents, with Lowry and Christofk as inventors.

The experimental drugs described above were used in preclinical tests only and have not been tested in humans or approved by the Food and Drug Administration as safe and effective for use in humans.

The research was supported by a California Institute for Regenerative Medicine training grant, a New Idea Award from the Leukemia and Lymphoma Society, the National Cancer Institute (R25T CA098010), the National Institute of General Medical Sciences (R01-GM081686 and R01-GM0866465), the National Institutes of Health (RO1GM094232), an American Cancer Society Research Scholar Grant (RSG-16-111-01-MPC), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (5R01AR57409), a Rose Hills Foundation Research Award and the Gaba Fund. The Rose Hills award and the Gaba Fund are administered through the UCLA Broad Stem Cell Research Center.

Further research on the use of UK5099 is being funded by the UCLA Technology Development Group through funds from California State Assembly Bill 2664.

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Stem cell agency eyes survival options – Capitol Weekly

Posted: at 1:42 pm

News

by DAVID JENSEN posted 08.14.2017

Californias $3 billion stem cell research agency, which is facing its financial demise in a few short years, has formed a team of its directors to tackle transition planning and examine possible alternatives, including ones that would extend its life.

The first meeting of the group of directors is tentatively scheduled for Sept. 18.Jonathan Thomas, chairman of the governing board of theCalifornia Institute for Regenerative Medicine(CIRM), as the agency is formally known, said earlier this summer:

The legislature has asked that we put together and start thinking about a transition plan, which can contemplate a variety of factors.In response to a question last week, a spokesman for the agency,Kevin McCormack, said that a notice with more details would be posted 10 days prior to the meeting.

At a meeting in June, Thomas laid out the need for the transition team. He said all options are on the table including asking the legislature for cash or to place a measure on the ballot for more bond funding.

The agencys only real source of money is state bonds, authorized by voters in 2004. It has roughly $600 million left. The agency has projected it will run out of cash for new awards in mid 2020, althoughthat could vary, depending on whether it slows down the pace of awards.

Several directors at the board meeting in June expressed a sense of urgency about dealing with the fate of the agency. CIRM DirectorJeff Sheehy, a member of the San Francisco board of supervisors and an HIV/AIDS patient advocate, voiced concern about the uncertain nature of the agencys future.

Sheehy said,It seems to me that we will be talking about a substantial scaling back of the organization in2020.Weve kind of created this expectation that we were going to go to 2018 and come back with new money.

Sheehy referred to talk that a new bond initiative might be launched in 2018, a move that the boards former chairman,Robert Klein, has publicly advanced. Sheehy said, however, that he spoke with Klein, who told him that he wasnow considering 2020 instead.Kleins method would require the gathering of hundreds of thousands of valid voter signatures to place the proposal on the ballot and would bypass the legislature.

The year 2020 includes a presidential election, which has higher voter turnout and generally is considered a better time to win approval of bond measures. Presumably, the agency might be able to secure extra funding to span any financial gap or, alternatively, lower the frequency of awards to stretch out the cash.

The members of the transition group are Thomas, Sheehy,Art Torres, Steve Juelsgaard, Joe Panetta, Kristiina Vuori, Linda Malkas, Diane Winokur, Shlomo Melmed, Al RowlettandJudy Gasson.Short bios on each of them can be found via this page.

TheCalifornia Stem Cell Reportwill carry an item with the date and location of the September meeting when it becomes available.Eds Note:DavidJensenis a retired newsman who has followed the affairs of the $3 billion California stem cell agency since 2005 via his blog, the California Stem Cell Report,where this story first appeared.He has published more than 4,000 items on California stem cell matters in the past 11 years.

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Stimulating Stem Cells to Encourage Hair Growth – Anti Aging News

Posted: at 1:42 pm

Scientists have discovered a new way to stimulate the stem cells in the hair follicle to make hair grow, opening the door to the development of new drugs for those with baldness or alopecia.

UCLA researchers have revealed a new way to activate stem cells within hair follicles that stimulate hair growth. The hope is this discovery will lead the way to the development of drugs that allow bald individuals and those with alopecia to once again grow hair. The research was led by scientists William Lowry and Heather Christofk of UCLA’s Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research. The details of theirfindings were recently published in Nature Cell Biology.

About Hair Follicle Stem Cells

Hair follicle stem cells are best described simply as older cells within hair follicles that are present in human skin. They generate hair across an individual’s lifetime. These cells are quiescent, meaning they are typically dormant yet they can activate quite rapidly in a new hair cycle when the growth of new hair occurs. The hair follicle stem cells’ quiescence is regulated by an array of factors. In some instances, they do not activate and hair loss occurs.

Study Details

The researchers determined the metabolism of hair follicle stem cells is unique from other skin cells. Cellular metabolism occurs when nutrients necessary for cell division break down, create energy and react to their environment. The metabolism process makes use of enzymes that changenutrients to generate metabolites. Hair follicle stem cells gradually consume a form of sugar, known as glucose, from the body’s bloodstream. The glucose is processed to gradually create a metabolite known as pyruvate. The cells subsequently send pyruvate to the mitochondria (the portion of the cell that generates energy) or convert pyruvate to another metabolite referred to as lactate.

The researchers blocked the generation of lactate in mice. This prevented the activation of hair follicle stem cells. The UCLA team worked with University of Utah Rutter lab academicians to boost lactate production in mice. This hastened the activation of hair follicle stem cells, causing an increase in the hair cycle. Prior to this, no one knew boosting or decreasing lactate would make an impact on hair follicle stem cells. Now that the researchers have determined how changing lactate production in mice changes hair growth, they can attempt to identify drugs that can be applied to the skin to produce the same effect.

Drugs of Note

The research groups identified a couple drugs that alter hair follicle stem cells in specific ways to boost lactate production when applied to mice skin. One of the drugs, RCGD423, triggers a cell signaling pathway referred to as JAK-Stat that transmits information from outside cells to the cell nucleus. Research shows JAK-Statactivation causes an increase in the generation of lactate. This spurs the activation of hair follicle stem cells and results in faster hair growth.

The second drug of note, UK5099, stops pyruvate from entering mitochondria. This forces the generation of lactate within the hair follicle stem cells, boosting the rate at which hair grows in mice. These experimental drugs were strictly used during pre-clinical testing. They have not been tested in human beings. Nor have these drugs been approved by the Food and Drug Administration as safe or effective for humans.

Why the Study Matters

This study is important as it provides plenty of insight into the many ways in which stem cells are activated. The idea of using drugs to catalyze hair growth by way of hair follicle stem cells is quite promising considering the millions of individuals who are bald or going bald. The researchers’ findings will help improve the understanding of how metabolism affects hair growth as well as stem cells.

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Researchers Discover New Key to Hair Growth – R & D Magazine

Posted: at 1:42 pm

New drugs promoting hair growth may soon be on the market, as researchers from UCLA have developed a new way to activate the stem cells in the hair follicle to make hair grow.

Hair follicle stem cells are long-lived cells in the hair follicle that are present in the skin and produce hair throughout a persons lifetime. The stem cells are normally inactive, but can quickly activate during a new hair cycle when growth occurs.

The researchers discovered that the hair follicle stem cell metabolism is different from other cells of the skin.

The metabolism uses enzymes that alter nutrients to produce metabolites, and as hair follicle stem cells consume glucose from the bloodstream, they process the glucose to eventually produce a metabolite called pyruvate.

The cells then can either send pyruvate to their mitochondriathe part of the cell that creates energy or they can convert pyruvate into another metabolite called lactate.

Our observations about hair follicle stem cell metabolism prompted us to examine whether genetically diminishing the entry of pyruvate into the mitochondria would force hair follicle stem cells to make more lactate, and if that would activate the cells and grow hair more quickly, Heather Christofk, a scientist at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, said in a statement.

The researchers blocked the production of lactate genetically in mice and found that the hair follicle stem cell was prevented from activating.

They then collaborated with researchers from the University of Utah and increased lactate production genetically in the mice to accelerate hair follicle stem cell activation and ultimately increasing the hair cycle.

Before this, no one knew that increasing or decreasing the lactate would have an effect on hair follicle stem cells, William Lowry, a professor of molecular, cell and developmental biology at UCLA, said in a statement. Once we saw how altering lactate production in the mice influenced hair growth, it led us to look for potential drugs that could be applied to the skin and have the same effect.

A pair of drugs have already been identified and tested. When the drugsRCGD423 and UK5099were applied to the skin of mice they influenced hair follicle stem cells in distinct ways to promote lactate production.

RCGD423 activates the JAK-Stat cellular signaling pathway, which transmits information from outside the cell to the nucleus of the cell and leads to the increased production of lactate, which drives hair follicle stem cell activation and quicker hair growth.

UK5099 blocks pyruvate from entering the mitochondria, forcing the production of lactate in the hair follicle stem cells and accelerating hair growth in mice.

Through this study, we gained a lot of interesting insight into new ways to activate stem cells, Aimee Flores, a predoctoral trainee in Lowry’s lab and first author of the study, said in a statement. The idea of using drugs to stimulate hair growth through hair follicle stem cells is very promising given how many millions of people, both men and women, deal with hair loss.

I think we’ve only just begun to understand the critical role metabolism plays in hair growth and stem cells in general; I’m looking forward to the potential application of these new findings for hair loss and beyond.

The study was published in Nature Cell Biology.

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New SpineScreen app helps parents detect signs of scoliosis in kids – Markets Insider

Posted: at 1:42 pm

TAMPA, Fla., Aug. 15, 2017 /PRNewswire/ –Parents can now check their child’s spine for possible signs of scoliosis with the new app SpineScreendeveloped by Shriners Hospitals for Children. Available for free on the App Store and Google Play, SpineScreen detects curves as the cell phone is moved along a child’s back, giving parents a quick, informal way to regularly monitor their child’s spine.

Scoliosis is an abnormal curvature of the spine that can restrict movement and in some cases lead to other serious medical conditions. It is most commonly diagnosed between 10 and 15 years of age, when children grow rapidly. Some cases, however, can go undetected. At this point in a child’s life, fewer vaccinations are required, so they may see a doctor less often. Since early detection is crucial, Shriners Hospitals physicians encourage parents to download the free SpineScreen app and check kids as part of their back-to-school routine each year.

“Because there is often no known cause, monitoring for scoliosis is an important part of a child’s ongoing health care,” says Amer Samdani, M.D., chief of surgery for Shriners Hospitals for Children Philadelphia. He adds, “It is a progressive condition, so early detection is key. At Shriners Hospitals, our care ranges from routine monitoring to some of the most advanced treatments for scoliosis. The earlier we see a child, the more options we have available.”

Shriners Hospitals created the app as part of a broader initiative to highlight the importance of regular screenings and to educate parents on the signs of scoliosis and treatment options.

“With doctors and staff who are global leaders in the treatment of scoliosis care, parents turn to Shriners Hospitals for Children because they know their children will receive the best care possible,” Gary Bergenske, chairman of the Board of Directors for Shriners Hospitals for Children. “Since scoliosis usually requires ongoing medical treatment throughout childhood, our commitment to provide care regardless of the families’ ability to pay is a huge relief to parents.”

If you have immediate concerns about your child’s spine or other possible medical conditions, please consult your health care provider. For more information on scoliosis screenings, treatment options and to download the SpineScreen app, please visit shrinershospitalsforchildren.org/scoliosis.

About Shriners Hospitals for Children

Shriners Hospitals for Children is changing lives every day through innovative pediatric specialty care, world-class research and outstanding medical education. Our 22 locations in the United States, Canada and Mexico, provide advanced care for children with orthopaedic conditions, burns, spinal cord injuries, and cleft lip and palate. Learn more at shrinershospitalsforchildren.org.

Shriners Hospitals for Children is a 501(c)(3) nonprofit organization and relies on the generosity of donors. All donations are tax deductible to the fullest extent permitted by law.

Contact: Meredith ResnickEmail: rel=”nofollow”>[email protected]: 202-549-0807

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SOURCE Shriners Hospitals for Children

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Robotic Training Method May Improve Gait, Posture in Kids with Cerebral Palsy, Researchers Say – Cerebral Palsy News Today

Posted: at 1:41 pm

A new robotic training method targeting posture and crouch gait in children with cerebral palsy (CP) was developed by a research team from theSchool of Engineering and Applied Science at Columbia University.

In a pilot study titled Robot-driven downward pelvic pull to improve crouch gait in children with cerebral palsy, published in the journalScience Robotics, team leader Sunil Agrawal described how his teams robotic training system was engineered to improve muscle strength and coordination.

One of the major reasons for crouch gait is weakness in soleus muscles, Agrawal, a professor of mechanical engineering and of rehabilitation and regenerative medicine, said in a news release. Thesoleus isan extensor muscle from just below the knee to the heel that plays a key role in preventing the knee fromcollapsing and providing propulsion during movement, or gait cycles.

We hypothesized that walking with a downward pelvic pull would strengthen extensor muscles, especially the soleus, against the applied downward pull and would improve muscle coordination during walking, Agrawal said.

We took an approach opposite to conventional therapy with these children: Instead of partial body weight suspension during treadmill walking, we trained participants to walk with a force augmentation, he said.

Knowing that the soleus muscle is activated more intensely when weight is added to the body during walking, researchers focused on strengthening the soleus, hypothesizing that this would help children with crouch gait increase their standing and walking abilities.

The researchers developedthe Tethered Pelvic Assist Device (TPAD) system as a light, wearable, cable-driven robot that assists movement when walking on a treadmill.

TPAD is a unique device because it applies external forces on the human body during walking, said Jiyeon Kang, a PhD candidate and lead author of the study. The training with this device is distinctive because it does not add mass/inertia to the human body during walking.

Working with six children with cerebral palsy over six weeks, the team examined their muscle strength and coordination while continuously monitoring motion and ground reaction forces.

They found that the training was effective in both enhancing the childrens upright posture and improving their muscle coordination. Other walking features like step length and range of motion also improved.

Feedback from the parents and children involved in this study was consistent. They reported improved posture, stronger legs, and faster walking speed, and our measurements bear that out, said Heakyung Kim, a Columbia University professor of pediatrics who treated the children involved in the trial.

We think that our robotic TPAD training with downward pelvic pull could be a very promising intervention for these children, Kim added.

Among other symptoms of cerebral palsy, such as slow walking speed or reduced range of motion of the joints, crouch gait is characterized by excessive flexion of the hips, knees, and ankles. Its caused by a combination of weak extensor muscles that cant hold an upright posture along with tight flexor muscles that limit the joints range of motion.

While providing propulsion to complete the gait cycle, the soleus keeps the shank upright during the mid-stance phase of the cycle to help the knee extend properly.

Currently, there is no well-established physical therapy or strengthening exercise for the treatment of crouch gait, Agrawal said.

The research team plans to continue testing the robotic training methodin clinical studies, eventually with larger groups of patients and potentially with children who have hemiplegic and quadriplegic cerebral palsy.

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Marvel Creates New Team of Superheroes Affected by IBD – IBD News Today

Posted: at 1:41 pm

Marvel Custom Solutions has partnered with Seb Tucknott, the founder of the online platform IBDRelief and pharmaceutical companyTakeda,to create a new team of superheroes who all have one thing in common:inflammatory bowel disease (IBD).

MORE:Sevenpeople with chronic illnesses who used a body-shaming experience to raise awareness

According to a report on metro.co.uk, the Unbeatables are allaffected by either Crohns disease or ulcerative colitis, along with an estimated onein 250 Britons. While fighting crime and protecting people around the world, the Unbeatables also pause to consider how their superhero actions may affect their IBD, including the impact of stress.

The team is made up of five characters:

Marvel has created a full graphic novel featuring the adventures of the Unbeatables to raise awareness of IBD. The first chapter was revealed at Londons Comic Con to more than 100,000 Marvel fans. The cover of the novel was created by Marvels Kirbi Fagan, an illustrator who also lives with Crohns disease.

MORE: Seven famous personalities with ulcerative colitis

IBD News Todayis strictly a news and information website about the disease. It does not provide medical advice,diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician orother qualified health providerwith any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

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Ocean City to host Crohn’s, colitis 5k walk/run Sunday – Press of Atlantic City

Posted: at 1:41 pm

Several hundred people are expected to turn out in Ocean City this weekend in support of research and treatment for people with Crohns disease and ulcerative colitis.

Ocean City will host the Crohns and Colitis Foundations Guts and Glory 5k run and walk Sunday and organizers said they are expecting as many as 1,800 race participants.

Crohns and colitis are digestive diseases impacting more than 1.6 million American adults and children, according to the foundation.

Patients often experience a range of symptoms and flare-ups throughout their lives, including, but not limited to, weight loss, fatigue, internal tearing and bleeding and abdominal cramps.

There is no cure for Crohns disease, but doctors and other specialists are able to treat people in order to manage the condition with medications like corticosteroids, antibiotics and biological therapies.

Advocates and supporters can register for the race online up until 12 p.m. Saturday or in person Sunday from 7:30 to 8:25 a.m. before the race at the Aquatics and Fitness Center, 1735 Simpson Ave., Ocean City.

Pre-registered racers can pick up their event packets at the fitness center Saturday from 2:30 to 6 p.m.

This years race will spotlight its 2017 honored hero, Ashlynn Vanaria, of Moorestown, Burlington County, who was diagnosed with Crohns disease at 11 years old.

Vanaria and her family have supported the Guts and Glory 5k event for the past 10 years by advocating for support and raising money for the foundations causes. To date, they have raised more than $50,000 for Crohns and colitis treatment and research.

My family and I have spent the summers in Ocean City my entire life and learned about the Guts and Glory 5k two years after my diagnosis, Vanaria said in a statement. We look forward to this event all year. We will not give up, we will continue to fight and we will find cures.

Race participants are encouraged to donate money as individual entries or as a team. Supporters of participants can also make donations in the name of runners or walkers online. The event has raised, as of Monday, nearly $57,000.

The walk/run will begin at 8:30 a.m. at the fitness center and later include music, food and an awards ceremony. The events primary sponsor is Edmunds and Associates and will feature tables of local organizations and providers, including Shore Medical Center.

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Ocean City to host Crohn’s, colitis 5k walk/run Sunday – Press of Atlantic City

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