Contact Information Available for logged-in reporters only Newswise Philadelphia, Dec. 6, 2014 An innovative cell therapy against a highly aggressive form of acute lymphoblastic leukemia (ALL) continues to show highly promising results in children treated in a pilot study. Ninety-two percent of the 39 children receiving bioengineered T cells had no evidence of cancer at one month after treatment, with this complete response persisting in some cases for more than two years. The personalized cell therapy reprograms a patients immune system and offers the potential of long-term success. As we continue to follow children in this study, we see exciting results for patients who have exhausted their other treatment options, said study leader Stephan A. Grupp, M.D., Ph.D., a pediatric oncologist at The Childrens Hospital of Philadelphia and a Professor of Pediatrics at the Perelman School of Medicine of the University of Pennsylvania. Grupp described outcomes and follow-up results of this pilot clinical trial for pediatric patients with ALL in a press program today at the annual meeting of the American Society of Hematology (ASH) in San Francisco. Grupp, first author Shannon Maude, M.D., Ph.D., a pediatric oncologist at CHOP and Assistant Professor of Pediatrics at the Perelman School of … Continue reading
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