Sep. 3, 2013 Breast cancer risk associated with use of hormone replacement therapy (HRT) among postmenopausal women was variable when analyzed by race/ethnicity, body mass index (BMI), and breast density, according to a new study published September 3 in the Journal of the National Cancer Institute. Studies have reported HRT use is associated with an increase in breast cancer risk. However, differential risks by BMI and breast density have been reported. Also, studies on the effect of HRT use on breast cancer risk among black women have reported inconsistent results. Ningqi Hou, M.H.S., Ph.D., from the University of Chicago, in Chicago, IL, and colleagues analyzed 1,642,824 screening mammograms, which included 9,300 breast cancer cases, from postmenopausal women from the Breast Cancer Surveillance Consortium, a US registry of mammography screening. Data on HRT use were analyzed by race/ethnicity, age, BMI, and breast density using statistical methods to accommodate missing information on HRT use and other covariables. Statistically significant interactions between HRT use and each covariable were calculated. A greater than 20% increased risk in breast cancer was associated with HRT use among white women and Hispanic women, but not black women. HRT use was more strongly associated with breast cancer risk … Continue reading
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