Orgenesis Inc. (ORGS) is an emerging biotechnology firm developing a new technology for regeneration of functional insulin-producing cells, thus enabling normal glucose regulated insulin secretion, via cell therapy. In this interview, Jacob BenArie MBA, B.Sc., President & CEO shares some detailed thoughts about his firm: Question: Several cutting-edge treatments for diabetes have been proposed over the years. Why is now the right time to develop your approach, involving the use of a patient`s own cells to secrete insulin? Jacob BenArie: Orgenesis`s approach involves transdifferentiation, which is the conversion of one adult cell type into an alternate type of adult cell with a distinct function. This approach bypasses the hazard of tumor formation upon implantation associated with two alternative approaches, involving the use of embryonic stem cells or induced pluripotent stem cells. Transdifferentiation is currently being analyzed for feasibility and safety in preclinical studies. Given the conceptual breakthrough represented by this process, it is not entirely surprising that it is not yet used in the clinic. By the year 2000, only a little more than a decade ago, common knowledge held that adult tissues in mammals are terminally differentiated. It takes comprehensive studies to change this dogma and demonstrate the clinical … Continue reading
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