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Stroke rehab glove combines mental practice and muscle stimulation to improve hand function

Posted: Published on September 12th, 2012

Recovering stroke patients may soon have a new device to help them work on regaining control of their hands without help from a physical therapist. Its a medical device in the form of a glove, and the company making it wants to actively engage the brains of these patients to help re-establish the neural connections between the brain and muscles in the hand. The glove, being developed by HandMinder, includes a set of programmable micromotors that sits on the wrist and send sequences of vibrations to the fingers and wrist. The idea is that those vibration would trigger the brain to send movement signal to the right muscles. About 795,000 Americans have strokes each year, and 40 percent of them experience impairments that require special care, according to the National Stroke Association. Current treatments, like functional electrical stimulation, leave out a key piece in rehabilitation, Bell said. They provide a one-way street to the brain, or a stimulation that makes something happen locally, he said. Electrical stimulation causes the movement. A physical solution is being applied to what is largely a neurological problem. The science behind the device is based on research by co-founder and neuroscientist Yu Liu at the … Continue reading

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Heart and Stroke Foundation (HSF) changes French name to better reflect commitment to stroke research and prevention

Posted: Published on September 12th, 2012

New name: Fondation des maladies du cur et de l'AVC OTTAWA, Sept. 12, 2012 /CNW/ - The Heart and Stroke Foundation announces a change to its French name. "AVC" - the abbreviation for the French term for stroke, 'accidents vasculaires crbraux' - will be added to the Foundation's current French corporate name and logo. Referring to both heart disease and stroke, the name Fondation des maladies du cur et de l'AVC more accurately reflects the organization's mission and also more closely resembles its English counterpart. The change is effective immediately. "The work we do in the field of stroke is just as important as our work in heart disease, and our name should reflect this in both English and French," says David Sculthorpe, CEO of the Heart and Stroke Foundation of Canada. "Adding those three letters will make our mission clearer to our donors, volunteers, the scientific community and the general public, and at the same time help reinforce our commitment to healthy lives free of heart disease and stroke." La Fondation des maladies du curhas been used for more than twenty-two years, and though it is well known to its donors, partners and public, it lacked any reference to … Continue reading

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Former player Marc Buoniconti relates to Tulane safety Devon Walker's condition

Posted: Published on September 12th, 2012

Marc Buoniconti knows first-hand the pain a spinal cord injury can cause. In 1985, as a linebacker for The Citadel, he suffered a cervical spine injury like Tulane's Devon Walker did last weekend against Tulsa. Buoniconti said he saw Walker's injury and believes he can recover. "I saw the play. His arms and legs did not go limp," said Buoniconti, who was paralyzed from the shoulders down and spent the seven months after his injury on a respirator."So I feel that if he has an incomplete injury that his chance of recovery can dramatically increase." An incomplete motor injury, according to Dr. T. George Hornby, a research scientist/physical therapist at the Rehabilitation Institute of Chicago, occurs when a patient with a spinal cord injury has "some volitional muscle activity that could lead to greater potential for recovery utilizing their legs and arms." Buoniconti co-founded the Miami Project with his father, Nick, and Dr. Barth Green, and they've joined forces for the past 27 yearsto tirelessly explore research into treatment for spinal cord injuries like heand Walker suffered. One of those is "modest hypothermia," a method of lowering the body temperature to cool the spinal cord. Buoniconti said the hypothermia treatment … Continue reading

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Concussion Awareness Helps Reduce Long-Term Complications

Posted: Published on September 12th, 2012

Newswise While involvement in school sports is probably one of the healthiest things, physically and mentally, your child can do, the pressure to play harder and practice longer brings an increased risk of head injury. Medical, sports and school communities are all taking a serious new look at how to treat concussions caused by a hit to, or shaking of, the head. Falls during equestrian, cheerleading and gymnastics events are producing concussions at an increasing rate, along with the more obvious contact sports like football and soccer. A concussion is a type of traumatic brain injury (or TBI) and it is similar to a stroke in that both affect normal brain function and may have similar symptoms, explained Neurologist Frederick Nahm, MD, PhD, and head of the Stroke Center at Greenwich Hospital in Greenwich, Connecticut.. Immediate symptoms may include confusion, disorientation and sometimes falling unconscious. Ignoring these symptoms is outright dangerous. During a game, your adrenaline is going and youre pumped up, so its easy to brush it off. But whether you bump your head during sports, a car accident, a fall or during military activity, it may not be until that night or a few days later that you … Continue reading

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Opexa Initiates Late Stage Clinical Study of Tcelna in Patients with Secondary Progressive Multiple Sclerosis (SPMS)

Posted: Published on September 12th, 2012

THE WOODLANDS, Texas--(BUSINESS WIRE)--Opexa Therapeutics, Inc. (NASDAQ:OPXA), a company developing Tcelna, a novel T-cell therapy for multiple sclerosis (MS), today announced the initiation of a Phase IIb clinical trial of Tcelna in patients with Secondary Progressive Multiple Sclerosis (SPMS). Several patients have already been enrolled in the study and enrollment is expected to increase rapidly as additional sites begin screening and enrolling patients in the coming weeks. Tcelna is the first ever personalized T-cell therapy for MS patients and has received Fast Track Designation from the United States Food and Drug Administration (FDA) for the treatment of SPMS. The therapy is specifically tailored to each patients individual disease profile and has demonstrated superior safety and encouraging indications of efficacy in previous clinical studies in MS that included the treatment of SPMS patients. There is currently only one FDA-approved treatment for SPMS but safety warnings have severely restricted its use. While a positive trial outcome will certainly be good news for SPMS patients, it is also not difficult to envision that it could position Tcelna as a promising treatment for the larger RRMS patient population as well. The newly initiated trial, named Abili-T, is a randomized, double-blind, placebo-controlled clinical study in … Continue reading

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Brain Health Institute gains MS researcher

Posted: Published on September 12th, 2012

The Universitys Brain Health Institute is expanding research on the treatment of brain disorders thanks to Cheryl Dreyfus, a leading multiple sclerosis researcher. Dreyfus, professor and chair of the Department of Neuroscience and Cell Biology at Robert Wood Johnson Medical School, said since she began working on models of the disease in tissue cultures, she hoped to approach a treatment for the autoimmune disease that affects about 350,000 people in the United States. We really dont know well what MS is, but were finding growth factors that affect cells in development can also affect those cells that are dying in MS [patients], she said. Dreyfus said her lab team is examining a protein called brain-derived neurotrophic factor (BDNF), which can help create new brain cells and prevent existing ones from dying. In patients with MS, the myelin sheath, or protective covering that insulates brain cells, disintegrates, Dreyfus said, leading to symptoms ranging from muscle spasms and difficulty speaking to visual impairment and depression. Many treatments for MS deal with treating inflammation that occurs when the sheath around the brain cells diminishes, Dreyfus said. But her labs approach to finding a treatment focuses on recovering brain function, she said. Her partnership … Continue reading

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Mesoblast Selects Medidata’s Cloud-based Clinical Research Platform to Accelerate Cutting-edge Stem Cell Research

Posted: Published on September 12th, 2012

NEW YORK--(BUSINESS WIRE)-- Medidata Solutions (MDSO) continues to lead the market with its cloud-based clinical development platform through a new customer commitment from Mesoblast Limited, a world leader in developing biologic products for the broad field of regenerative medicine. Mesoblast will implement Medidata Rave, including Rave Safety Gateway and Rave Targeted SDV, and Medidata Coder across its clinical studies to support the development of treatments based on its proprietary adult stem cell technology. Medidatas platform is seen as a cost-efficient solution to improve Mesoblasts clinical trial efficiencies across multiple therapeutic areas, to effectively monitor and control risks, and to streamline trial execution to meet tight deadline goals. Medidata Rave, a leading electronic data capture (EDC) and clinical data management (CDM) solution, enables real-time visibility into clinical trial data. The flexibility of Rave allows Mesoblast to proactively adjust a trials data validation plan and management processes, and also apply learnings to other studies in a timely fashion to improve trial quality and efficiency. Mesoblast selected Rave for its superior user experience and comprehensive functionality. The context-sensitive, on-screen help minimizes the dependence on calling help desks and eliminates delays in entering and cleaning data. Moreover, research sites familiarity with Rave will help … Continue reading

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California's stem cell agency boosts heart disease research at Sanford-Burnham

Posted: Published on September 12th, 2012

Public release date: 12-Sep-2012 [ | E-mail | Share ] Contact: Heather Buschman, Ph.D. hbuschman@sanfordburnham.org 858-795-5343 Sanford-Burnham Medical Research Institute LA JOLLA, Calif., September 12, 2012 The California Institute for Regenerative Medicine (CIRM) has awarded a $1.58 million grant to Huei-Sheng Vincent Chen, Ph.D., associate professor at Sanford-Burnham Medical Research Institute (Sanford-Burnham). Chen's proposal was one of 28 new projects funded as part of CIRM's Basic Biology IV awards program, which supports basic research aimed at increasing our understanding of stem cells and how to work with them. This new funding will allow Chen and his team to develop personalized models of inherited heart conditions using stem cells derived from patients' own skin cells. They will also use these models to develop new therapies. "Most heart conditions that cause sudden death in young peoplethose under age 35are caused by inherited genetic mutations. But doctors have a hard time treating these types of heart conditions because not much is known about how genetic mutations cause them and because they're usually diagnosed late in the disease process," Chen said. "At the moment, the only way to treat these inherited heart diseases is to implant a heart-shocking device to prevent sudden death. More … Continue reading

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Licensing Executives Society Annual Meeting Keynote Speaker Eric Topol Says High Tech Medical and Digital Innovations …

Posted: Published on September 12th, 2012

WASHINGTON--(BUSINESSWIRE)-- The convergence of new high tech medical and digital tools are revolutionizing health care, according to renowned cardiologist and genetic researcher Eric Topol, who is working to secure widespread use of these innovations to design treatments specifically for patient populations based on their unique genetic maps. During an interview promoting his upcoming address at the Licensing Executives Society (U.S.A. and Canada) Annual Meeting, October 14-17 in Toronto, Dr. Topol urged the medical community to reboot its approach. (www.les2012.org/podcast) Its a really extraordinary time in medicine that requires us to reboot how we operate as a profession and how we render care. It has a profound rippling effect across the life science industry, academics and the regulatory authority because we have new found capabilities of digitizing each human being to the essence of what makes each person tick, said Dr. Topol. In his LES keynote address, Connecting & Collaborating: The Convergence of Life Sciences and High Tech, Dr. Topol, who in 2012 was voted the Most Influential Physician Executive in Health Care by Modern Healthcare and Doctor of the Decade by the Institute for Scientific Information, will share his vision for the future and discuss the complicated implications of change. … Continue reading

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Medistem Advances Type 1 Diabetes Stem Cell Technology Licensed From Yale

Posted: Published on September 12th, 2012

SAN DIEGO, CA--(Marketwire - Sep 12, 2012) - Medistem Inc. ( PINKSHEETS : MEDS ) announced today completion of the first phase of a joint project with the Shumakov Research Center of Transplantology and Artificial Organs of the Russian Federation and its Russian and CIS licensee ERCell.The collaboration is based on using Endometrial Regenerative Cell (ERC) technology licensed from Yale University to treat type 1 diabetes. Dr. Viktor Sevastianov, Head and Professor of the Institute of Biomedical Research and Technology, within the Shumakov Center, demonstrated safety and feasibility of ERC injection in experimental animal models of diabetes.Additionally, the studies demonstrated that the cell delivery technology developed by Dr. Sevastianov's laboratory can be used to enhance growth of ERC.These experiments are part of the process for registration of "new pharmacological substances," which is the first step towards drug approval in Russia. "Type 1 diabetes is a significant problem in the Russian Federation. Our laboratory has been working developing various delivery formulations for cell therapy, such as SpheroGel, which is registered in Russia," said Dr. Sevastianov. "Given that the ERC can be produced in large quantities, is a universal donor cell, and already is approved for clinical trials in both the USA … Continue reading

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