Vascular Biology | Surgery Research | Michigan Medicine …

Our faculty have been leading advances in vascular biology, disease and surgery.The work of our surgeon scientists is changing what we know about vascular biology and disease as well as how we care for our patients across a range of disease processes.

We have investigated many facets of venous and arterial thrombosis (VT), such as the role of inflammationincluding the enzyme CD39as well as the role of the plasminogen system, polyphosphates, sepsis, cancer and genetics, and the prevention of post-thrombotic syndrome. In addition, wedeveloped new animal models of VT, which also have helped lead to identification of new therapeutic targets, including the selectin group of cell-adhesion molecules, and promising agents that will soon move into clinical trials. Our faculty members have identified key mechanisms underlying impaired wound healing in Type 2 diabetes, including the discovery of the role of the Ly6CHimacrophage as a key driver of persistent inflammation. Teams have also led investigations into the genetics of fibromuscular dysplasia, a rare but serious condition that causes narrowing of the arteries and can lead to high blood pressure, arterial tears or stroke.

Our team has generated new insights into patient decision-making with respect to peripheral artery disease. While decision analysis has been explored in other areas of medicine, our work is the first within the field of vascular surgery.First analyses of clinical data from The Vascular Quality Initiative Varicose Vein Registry to understand treatment effectiveness, drive clinical standards and influence related policy.

We developed the minimally-invasive resuscitative endovascular balloon occlusion of the aorta, or REBOA, technique and catheter. Initially developed for use in the military theater to control hemorrhage, the REBOA catheter is now widely used in emergency rooms and Level 1 trauma centers. Our research also has led to the creation of innovative new products, such as a smartphone app for stroke detection and pressure-sensing socks to prevent diabetes-related lower-leg wounds. We have conducted award-winning device development work to assess and quantify frailty in vascular patients as well.

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Vascular Biology | Surgery Research | Michigan Medicine ...